Prehospital OMI recognized immediately by a fantastic paramedic
Written by Pendell Meyers, edits by Steve SmithThis case was sent by a paramedic who wishes to remain anonymous." The enclosed case resulted in a positive outcome, and I owe it entirely to the remarkable EKG tutorials on your website. "" A 65 y/o female was found uncomfortable, clammy, and complaining of chest pain. History of HTN, and high cholesterol. She had self medicated with aspirin prior to EMS arrival. " Here is her first EMS 12 lead:What do you think?" 12 Lead 1 (21:20:38) - V4 caught my eye as a hyperacute T-wave and indicative of total or at least subtotal occlusion. And the ST/T changes in III and aVF seal...
Source: Dr. Smith's ECG Blog - July 28, 2018 Category: Cardiology Authors: Pendell Source Type: blogs
Fight Aging! Newsletter, July 23rd 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - July 22, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Interview with Peter de Keizer of Cleara Biotech
The Life Extension Advocacy Foundation volunteers recently published a long and interesting interview with Peter de Keizer, the researcher who led development of the FOXO4-p53 approach to selective destruction of senescent cells. As senescence cells cause aging and age-related disease, there is considerable interest in developing means to remove them, and thus produce rejuvenation. The FOXO4-DRI used in de Keizer's study is probably the best of the current crop of senolytic compounds, as while the degree to which it kills senescent cells is broadly similar to the others, the evidence to date suggests that it produces insig...
Source: Fight Aging! - July 19, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Tropical Travel Trouble 010 Fever, Arthralgia and Rash
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
aka Tropical Travel Trouble 010
Peer Reviewer: Dr Jennifer Ho, ID physician QLD, Australia
You are an ED doc working in Perth over schoolies week. An 18 yo man comes into ED complaining of fever, rash a “cracking headache” and body aches. He has just hopped off the plane from Bali where he spent the last 2 weeks partying, boozing and running amok. He got bitten by “loads” of mosquitoes because he forgot to take insect repellent.
On examination he looks miserable,...
Source: Life in the Fast Lane - July 16, 2018 Category: Emergency Medicine Authors: Amanda McConnell Tags: Clinical Cases Tropical Medicine arthralgia dengue fever rash Source Type: blogs
A man in his 40s with chest pain
Case submitted and written by Alex Bracey, with edits by Pendell Meyers and Steve SmithThis ECG was tossed onto my desk on my first day of a new rotation at a community site. The technician was nowhere to be found by the time I turned to ask what the story is or where the patient is located.Initial ECG at 1350 - are you concerned? - There is 0.5 mm STE in aVL, no clear STE in lead I. - There is ST depression in II, III, and aVF. - Nicely demonstrated here, leads III and aVL are reciprocal: STD in III is reciprocal ST depression to STE in aVL.This is diagnostic of occlusion (OMI). - There is also some slight STD in V4-...
Source: Dr. Smith's ECG Blog - July 13, 2018 Category: Cardiology Authors: Pendell Source Type: blogs
Fight Aging! Newsletter, July 9th 2018
In this study, senescent cell distribution and quantity in vastus lateralis muscle were examined in young human adults after a single bout of resistance exercise. To determine the effects of dietary protein availability around exercise on senescent cell quantity and macrophage infiltration of skeletal muscle, two isocaloric protein supplements (14% and 44% in calorie) were ingested before and immediately after an acute bout of resistance exercise, in a counter-balanced crossover fashion. An additional parallel trial was conducted to compare the outcome of muscle mass increment under the same dietary conditions after 12 wee...
Source: Fight Aging! - July 8, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
MKSAP: 68-year-old man with heart failure
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 68-year-old man is evaluated at a follow-up appointment. He has a 7-year history of heart failure secondary to ischemic cardiomyopathy. Over the past 6 months, he has had three hospitalizations for exacerbations of his heart failure. He currently has exertional dyspnea while getting dressed, and his maximal activity level is limited to riding to the store with his wife but staying in the car. Medical history is significant for disseminated prostate cancer treated with androgen deprivation therapy. Medications ...
Source: Kevin, M.D. - Medical Weblog - July 7, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Cardiology Source Type: blogs
Can Aspirin Reduce the Risk of Alzheimer's Disease?
A regimen of low-dose aspirin may reduce plaques in the brain, which will reduce Alzheimer's disease pathology and protect memory, according to neurological researchers at Rush University Medical Center.ByAlzheimer's Reading RoomBuilding on previous studies demonstrating a link between aspirin and reduced risk and prevalence of Alzheimer's disease, researchers were able to show that aspirin decreases amyloid plaque pathology in the brain.Note to readers. I put this up because I started taking one quarter of an aspirin daily about 25 years ago. You might want to consider this and the findings of this research study.Wha...
Source: Alzheimer's Reading Room, The - July 3, 2018 Category: Neurology Tags: alzheimer Alzheimers Prevention alzheimers research alzheimers risk alzheimers treatment aspirin brain health memory Source Type: blogs
Aspirin Enhances Autophagy to Reduce Amyloid in Mouse Models of Alzheimer's
A number of groups advocate the use of NSAIDs such as aspirin as a means to reduce risk and postpone the development of Alzheimer's disease, based on the evidence accumulated in the past few decades. Aspirin is considered by some to be a calorie restriction mimetic that enhances autophagy, the cellular housekeeping mechanism that is required for calorie restriction to extend life in laboratory species. That said, I normally mention aspirin as a way to dampen excess enthusiasm for any new calorie restriction mimetic, autophagy-stimulating compound demonstrated to slow aging in the laboratory. After all, aspirin slows aging ...
Source: Fight Aging! - July 3, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Combining heartburn drugs and aspirin could help prevent oesophageal cancer in people at high risk
(Source: OnMedica Blogs)
Source: OnMedica Blogs - July 3, 2018 Category: General Medicine Source Type: blogs
Watch what happens when " pericarditis " and morphine cloud your judgment
Submitted and written by Alex Bracey with edits by Pendell Meyers and Steve SmithCaseA 50ish year old man with a history of CAD w/ prior LAD MI s/p LAD stenting presented to the ED with chest pain “similar to his prior MI, but worse.” The pain initially started the daypriorto presentation. The pain roused him from sleep but subsided without intervention. Around 19 hours later, he experienced the same pain, which prompted his presentation to the ED. By this time, three hours had passed from the onset of the pain but it was no longer present. Here is his initial ECG:00:04What do you think? - Sinus rhythm at ~70 bpmSTE in...
Source: Dr. Smith's ECG Blog - July 3, 2018 Category: Cardiology Authors: Pendell Source Type: blogs
Using Age-Related Gene Expression Changes to Search for Drugs to Slow Aging
In this study, using gene expression data for human brain ageing, we aimed to discover not only new pro-longevity drugs but also those that can improve health during ageing. The biological processes showing a change in expression include pathways related to synaptic and cognitive functions as well as proteostasis, suggesting gene expression changes in the ageing brain could be used as a surrogate to find drugs to target detrimental effects.
Using multiple gene expression datasets from brain tissue, taken from patients of different ages, we first identified the expression changes that characterise ageing. Then, we c...
Source: Fight Aging! - July 2, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Parapsychology has been unfairly sidelined, claims a new review of the field
By Alex Fradera
A number of notable figures from psychology’s past held an interest in parapsychology or psi (the study of mental phenomena that defy current scientific understanding), including William James, Alexander Luria, Binet, Freud, and Fechner. But today the field is cordoned off; and when it encroaches into mainstream publications, as with the “Feeling the Future” experiments conducted by Daryl Bem in 2012, furore typically follows. To sceptics, the fact that these experiments produced positive results is ipso facto proof that psychology’s methods must be broken.
However, it’s only logical to take ...
Source: BPS RESEARCH DIGEST - July 2, 2018 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: Parapsychology Source Type: blogs
MKSAP: 70-year-old man with a transient ischemic attack
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 70-year-old man is admitted to the hospital with a 1-hour episode of left arm and left leg weakness. He is diagnosed with a transient ischemic attack. The patient has a history of hypertension and type 2 diabetes mellitus and a 30-pack-year history of smoking. Family history is noncontributory. His medications are metformin and lisinopril.
On physical examination, the patient is afebrile, and blood pressure is 148/88 mm Hg. The remainder of the examination is unremarkable.
Laboratory studies show alanine amino...
Source: Kevin, M.D. - Medical Weblog - June 30, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Cardiology Neurology Source Type: blogs
Should You Try TMS (rTMS) for Depression?
TMS refers to transcranial magnetic stimulation (TMS), a treatment method for clinical depression first developed in the 1980s. In the psychology research literature, TMS is often referred to as rTMS — the little ‘r’ is for repetitive, because the treatment needs to be delivered at regular intervals to be most effective. What exactly is it?
TMS is a simple, safe, external outpatient treatment procedure that pulses very specific wavelengths of magnetic fields to specific areas of your brain through your skull. It is believed these magnetic pulses help to reduce depression symptoms when administered in a co...
Source: World of Psychology - June 26, 2018 Category: Psychiatry & Psychology Authors: John M. Grohol, Psy.D. Tags: Depression Disorders General Research Treatment Rtms Transcranial Magnetic Stimulation TRD Treatment Resistant Depression Source Type: blogs
