Fight Aging! Newsletter, April 4th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
TWiV 883: COVID-19 clinical update #108 with Dr. Daniel Griffin
In clinical update #107, Daniel Griffin reviews vaccine booster doses, at-home testing, transmission in hamsters, improving indoor air quality, trials of BCG, ivermectin, and fluvoxamine, vaccination during pregnancy, mRNA vaccines and Fc functions, anti-platelet and aspirin therapy and a trial of prone positioning. (Source: virology blog)
Source: virology blog - April 2, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation Long Covid monoclonal antibody Omicron pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
A Taxonomy of Degree of Effort in Undertaking Interventions to Slow or Reverse Aging
The urge to create taxonomies is very human, almost reflexive. We make lists, divide things up into buckets and categories. I'm not entirely convinced that there is yet the need to do this when it comes to personal efforts to slow or reverse aging, but that opinion certainly isn't going to stop people from publishing their thoughts on the matter. Today's open access paper is an example, in which a few arbitrary lines in the sand are drawn, and the spectrum of present day efforts to live longer is divided into five broad categories.
The one point that makes it, I think, hard to take any given taxonomy seriously is th...
Source: Fight Aging! - April 1, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 28th 2022
In conclusion, we summarized here evidence for a novel therapeutic approach to exploit the incredible ability of mitochondria to engage multifaceted neuroprotective stress response triggered by partial complex I inhibition. This approach promises relief for multiple human conditions, and to promote healthy aging to delay the onset of neurogenerative diseases, AD in particular, where age is the greatest risk factor. There is a mounting body of evidence generated in model organisms and humans in support of the safety of chronic application of complex I inhibitors. However, a better understanding of the molecular mechanisms i...
Source: Fight Aging! - March 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Understanding this pathognomonic ECG would have greatly benefitted the patient.
Written by Pendell MeyersInterpret this ECG first without context. You don ' t need context yet because this ECG is nearly pathognomonic.After having learned about benign T wave inversion pattern years ago on this blog, and having seen many cases on this blog and in my practice since then, I instantly recognize this as BTWI, a fairly common normal variant. I see maybe one of these ECGs each month in my practice. There is no ischemia, certainly no concern at all for OMI. It meets basically all of the criteria that Dr. Smith has consistently described over the years, after reviewing a large cohort of patients by W...
Source: Dr. Smith's ECG Blog - March 22, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
Effects of Geroprotective Drugs on Skeletal Health are Largely Unknown
The various geroprotective drugs capable of upregulating cellular maintenance processes in order to modestly slowing aging in short-lived laboratory species are a mixed bunch, ranging from the only technically geroprotective, including well characterized, and well used drugs such as aspirin, to drugs with very mixed data for small effects, such as metformin, through to the better end of the range such as mTOR inhibitors like rapamycin that reliably slow aging. Even in the case of rapamcyin, it remains unclear that the benefits in long-lived species such as our own are all that much better than a good exercise program or th...
Source: Fight Aging! - March 21, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
P. J. O ’Rourke and the Safety Nazis
David BoazP. J. O ’Rourke may not have coined the term “safety Nazi,”defined by the Urban Dictionary as “A person obsessed with safety and possessing a fascist belief that everyone who believes otherwise is irresponsible, reckless, and should be publicly chastised. ” But he does seem to have mainstreamed it. Glenn Garvinwrites inPolitico that he saw O ’Rourke use it in a magazine interview around 1980 and invited him to expand on the topic in an article forInquiry, a magazine founded by the Cato Institute and edited for a time by Garvin. P.J. did so in a 1982 article, which has just bee...
Source: Cato-at-liberty - February 25, 2022 Category: American Health Authors: David Boaz Source Type: blogs
Occlusion/reperfusion through 6 ‘normal’ ECGs
This is written and contributed by Jesse McLaren (@ECGCases), with comments and edits by Smith, and commentary by Ken Grauer (@EKGPress)An 80 year-old female presented with weakness and a fall, with normal vitals and no injuries. The ECG was labeled ‘normal’ by the computer, later confirmed by the cardiologist. What do you think? There ’s normal sinus rhythm, normal conduction, normal axis, normal R wave progression, and normal voltages. There’s usually a small amount of concave ST elevation in V2-3 but here there is horizontal ST depression in V2 and possibly V1. Smith: without any furt...
Source: Dr. Smith's ECG Blog - February 10, 2022 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
Subtle ECG Signs of OMI in LBBB
A 70 yo F with no previous cardiac history, but with a h/o hypertension, hyperlipidemia, and strong family history of ACS, presented with one hour of classic chest pain and appeared uncomfortable.Her systolic BP was 210. The ECG is here:Atypical LBBB (see explanation below)As for Occlusion MI (OMI), what do you think?A bedside echo was normal to that provider ' s eye (no bubble contrast).She had a CT for dissection that was negative.A 2nd ECG was recorded:There is an atypical left bundle branch block (LBBB) -- atypical because the R-wave in V6 is not all upright. But the Smith Modified Sgarbossa criteria w...
Source: Dr. Smith's ECG Blog - January 31, 2022 Category: Cardiology Authors: Steve Smith Source Type: blogs
Which ACS had more myocardial damage? The one that meets STEMI criteria, or the one with the'normal' ECG?
Discussion According to the current paradigm based on ECG millimeter criteria, the first patient had STEMI requiring emergent reperfusion while the second did not have STEMI so could have been treated with delayed reperfusion. But the second patient had a totally occluded artery leading to a large MI despite rapid reperfusion, and admitting them as “NSTEMI” with next day angiography could have been fatal. According to the discharge summaries, which seemed to be based on culprit lesions that received rapid reperfusion, both patients had “STEMI” despite the first never having a rise in troponin and the sec...
Source: Dr. Smith's ECG Blog - January 18, 2022 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
7 steps to missing posterior Occlusion MI, and how to avoid them
This fantastic case and post was written by Jesse McLaren (@ECGcases), edited by SmithCaseYou ’re shown an ECG from a patient in the waiting room with chest pain. What do you think?Sinus bradycardia, normal conduction, normal axis, normal R wave progression, no hypertrophy. There ’s primary ST depression in the precordial leads maximal in V3-4, and an inverted T wave in V2. There’s also a down-up T wave in aVL with a tiny bit of ST depression (which suggests inferior MI), but without associated inferior findings. Step 1 to missing posterior MI is relying on the STEMI criteria. A prospective valid...
Source: Dr. Smith's ECG Blog - January 3, 2022 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
Should we activate the lab? A simple but important lesson
Written by Pendell MeyersA man in his 60s called EMS for sudden chest pain and shortness of breath. He was found in moderate respiratory distress, hypertensive, diaphoretic, and hypoxemic. He was given aspirin, nitroglycerin, and placed on noninvasive positive pressure ventilation during transport. Medics recorded a 12-lead and transmitted it to the provider, asking if they wanted to activate the cath lab.Here is the ECG:What do you think?Sinus rhythm. In this EMS ECG, as is true for many EMS ECGs, the machine cuts off the S wave voltage at 10 mm. You can see this visually by the subtle but noticeable squared-off waveform ...
Source: Dr. Smith's ECG Blog - December 31, 2021 Category: Cardiology Authors: Pendell Source Type: blogs
Hyperacute T-waves -- missed. Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) may be due to transient thrombotic Occlusion MI.
Coronary thrombosis (twice in the same patient!!) without a stenosis or even a culpritDo not miss the last image at the bottom that shows the series of T-waves in V4-V6I recently had a discussion with an incredibly smart and fantastic ECG and Cardiology expert. He was skeptical that you can have OMI with Wellens waves without having a major stenosis on angiogram.I told him I ' ve seen it on occasion and that this happens due to thrombosis of non-obstructive lesions that lead to complete occlusion but that thencompletely lyse and do not show stenosis by the time of the angiogram. I said that even if there is not...
Source: Dr. Smith's ECG Blog - December 29, 2021 Category: Cardiology Authors: Steve Smith Source Type: blogs
Dynamic ST Depression in precordial leads. Does this transient STD signify subendocardial ischemia?
This case was written up by one of our fantastic 3rd year residents, Michael Fischer. Edits by Smith.A mid 60s male with past history of 2 prior STEMI(+) OMIs s/p stenting (most recently ~2 years ago) had onset of substernal chest pain after he came inside from smoking a cigarette. He reported becoming diaphoretic and also having pain in his L hand. After approximately one hour, he called 911. Medics arrived and recorded a prehospital ECG:Sinus rhythm. Deep QS-waves in inferior leads. Tall R-wave in V2, but no definite ST shifts or hyperacute T-waves.He was given aspirin and sublingual nitr...
Source: Dr. Smith's ECG Blog - December 23, 2021 Category: Cardiology Authors: Steve Smith Source Type: blogs
Fight Aging! Newsletter, December 20th 2021
In conclusion, the low dose, prolonged angiotensin II exposure is associated with the induction of senescence in kidneys and the promotion of an inflammatory microenvironment through both secreted factors and immune cells. Endothelial cells appear to be a major cell type impacted. The elimination of senescent cells in the INK-ATTAC transgenic model prevents these effects of angiotensin II and reveals a novel pathophysiologic mechanism amenable to targeting by senolytic drugs in development.
CYTOR Upregulation as a Path to Improved Muscle Function in Later Life
https://www.fightaging.org/archives/2021/12/cytor-...
Source: Fight Aging! - December 19, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
