Aspirin: Panacea or Piffle?

Aspirin is once again in the headlines, prompted by New England Journal of Medicine reports suggesting that people aged 70 years and older obtain no benefit and perhaps experience harm in the form of increased bleeding and increased death from cancer on low-dose aspirin. This adds to the decades-long debate on whether aspirin is beneficial as a preventive measure against cardiovascular events such as heart attack in which a blood clot forms on top of inflamed atherosclerotic plaque in the coronary arteries. Unlike many other studies that are observational and therefore virtually useless, these studies are prospective and randomized against placebo, studies that bear greater weight with conclusions that are more certain to establish cause-effect relationships. There is no question that people who have stents implanted in their coronary arteries, have bypass grafts, or have suffered a heart attack experience reduced risk of recurrent coronary events with aspirin, so-called “secondary prevention.” The tougher question comes in whether aspirin provides any benefits in primary prevention, i.e., lower-risk people without stents, bypass grafts, or prior heart attack. The three reports originated with the ASPREE trial of 19,000 Australians and Americans age 70 years or older, randomized to aspirin 100 mg per day vs. placebo: no difference in cardiovascular death or cardiovascular events (fatal heart attack, non-fatal heart attack, stroke) over nearly 5 years, with about a...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates aspirin coronary grain-free heart attack heart disease Inflammation platelets Weight Loss wheat belly Source Type: blogs

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This study aimed to assess the relative safety and short-term efficacy of drug-eluting bead transarterial chemoembolization (DEB-TACE) and conventional transarterial chemoembolization (c-TACE) for treating peculiar anatomical sites of gastric cancer liver metastasis. MATERIAL AND METHODS Of the 68 patients with gastric cancer liver metastases confirmed by imaging and pathology, 35 were treated with DEB-TACE and 33 with c-TACE. The DEB-TACE group comprised 26 males and 9 females aged 28-75 years (56.8±6.3), and the c-TACE group included 19 males and 14 females aged 33-77 (60.2±9.4) years. Liver functions of th...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS The network pharmacology analysis reveals the molecular biological mechanism of Artemisia annua anti-NSCLC via multiple active components, multi-channels, and multi-targets. This suggests that Artemisia annua might be developed as a promising anti-NSCLC drug. PMID: 32474568 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ01814G, PaperGurpreet Kaur, Monika Chaudhary, Kailash C Jena, Narinder Singh Abstract Environmental contamination due to increase in drug level is touching its alarming stage. There is an array of drugs such as antibiotics, antidepressants, analgesics, cancer chemotherapy drugs etc which... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Analyst, 2020, Advance Article DOI: 10.1039/D0AN00627K, PaperJun Liu, Cheng Cao We propose a novel GSH-generating prodrug to be used with a sulfonamide-induced “integrative” platform for selective cancer therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Dr Fauci says he hasn ’t spoken to Trump in two weeks; New Zealand to consider easing restrictions earlier than planned; Mexico deaths pass 10,000. Follow the latest updatesSingapore reopens schoolsUK: Critics round on No 10 over ‘ridiculous’ rules for 14-day quarantineAustralia coronavirus updates – liveCoronavirus latest: at a glanceSee all our coronavirus coverage6.46amBSTTheAssociated Pressis carrying a report that says Chinese officials sat on releasing the genetic map, or genome, of the coronavirus for over a week after multiple government labs had fully decoded it, not sharing details key to ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Infectious diseases Science Microbiology Medical research UK news US news Australia news Source Type: news
Publication date: Available online 31 May 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Badmus O. Olufunto, Njan Anoka, Ologe M. Olufunmilayo, Olatunji A. Lawrence
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research
BACKGROUND: The United States (US) and Canada are in the midst of an opioid overdose epidemic. Many people who use illicit drugs (PWUD) do not call an emergency number 911 at the scene of an overdose due to fear of arrest. In the US and Canada, when an ind...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
[DW] Following four deaths in western Congo, 1,000km from the ongoing outbreak, authorities have reported a new Ebola epidemic. "COVID-19 is not the only health threat people face," WHO chief Tedros said.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
(Medical College of Georgia at Augusta University) It's called icing sugar spleen, when the usually purplish organ looks like it has been dipped in unhealthy white icing, and the surface is bumpy and thick.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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