Synthesis, antimicrobial, and in silico studies of c5'- < em > O < /em > -substituted cytidine derivatives: cinnamoylation leads to improvement of antimicrobial activity
In this study, cytidine (1) was first exposed to react with cinnamoyl chloride in N,N-dimethylformamide, and trimethylamine to obtain 5'-O-(cinnamoyl)cytidine, which was further treated with several acylating agents to obtain a series of 2',3'-di-O-acyl derivatives. The chemical structures of the synthesized compounds were established through spectral, analytical, and physicochemical techniques. In vitro antimicrobial efficacy was evaluated, and the antimicrobial effect was greater than that of the precursor compound; in particular, compound 3 exhibited the most promising activity. Cytotoxicity measurements revealed that t...
Source: Nucleosides, Nucleotides and Nucleic Acids - March 28, 2024 Category: Biochemistry Authors: Tahmida Sultana Bhuiyan Mohamed A Said Md Z H Bulbul Sumeer Ahmed Ajmal R Bhat Mohammed Chalkha Sarkar M A Kawsar Source Type: research
Unravelling the Antimicrobial, Antibiofilm, Suppressing < em > Fibronectin Binding Protein A < /em > ( < em > fnba < /em > ) and < em > cna < /em > Virulence Genes, Anti-Inflammatory and Antioxidant Potential of Biosynthesized < em > Solanum lycopersicum < /em > Silver Nanoparticles
Conclusions: The findings from this study indicate that biosynthesized AgNPs from Solanum lycopersicum exhibit promising antimicrobial and antioxidant properties against UTI pathogens, including strains resistant to multiple antibiotics. This suggests their potential as an effective alternative treatment for UTIs. Further research is warranted to fully understand the mechanisms of action and to explore the therapeutic applications of these nanoparticles in combating UTIs.PMID:38541241 | PMC:PMC10972527 | DOI:10.3390/medicina60030515 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alsayed E Mekky Ahmed E M Abdelaziz Fady Sayed Youssef Shymaa A Elaskary Aly A Shoun Eman A Alwaleed Mahmoud Ali Gaber Abdulaziz A Al-Askar Alhadary M Alsamman Abdullah Yousef Gehad AbdElgayed Reda A Suef Mohamed A Selim Ebrahim Saied Mohamed Khedr Source Type: research
Combined allergic bronchopulmonary mycosis and eosinophilic granulomatosis with polyangiitis: A case report and literature review
Respir Med Case Rep. 2024 Mar 19;48:102012. doi: 10.1016/j.rmcr.2024.102012. eCollection 2024.ABSTRACTA 27-year-old female visited our hospital with a history of asthma, peripheral blood eosinophilia, increased total IgE, Aspergillus fumigatus specific IgE, reversible mild bronchiectasis, sinusitis, bronchial mucus plugs and cultivation of Aspergillus from BALF. Glucocorticoids therapy is effective. These results met the diagnostic criteria for both allergic bronchopulmonary aspergillosis (ABPM) and eosinophilic granulomatosis with polyangiitis (EGPA). Special attention should be paid to the possibility of both diseases co...
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Ning Cui Jingluan Wang Yanmei Shao Jingming Zhao Zhaozhong Cheng Source Type: research
Analysis of the remediation competence of Aspergillus flavus biomass in wastewater of the dyeing industry: An in-vitro study
Environ Res. 2024 Mar 26:118705. doi: 10.1016/j.envres.2024.118705. Online ahead of print.ABSTRACTThe dyeing industry effluent causes severe environmental pollution and threatens the native flora and fauna. The current study aimed to analyze the physicochemical parameters of dyeing industry wastewater collected in different sites (K1, E2, S3, T4, and V5), as well as the metal tolerance and decolourisation ability of Aspergillus flavus. Furthermore, the optimal biomass quantity and temperatures required for efficient bioremediation were investigated. Approximately five dyeing industry wastewater samples (K1, E2, S3, T4, and...
Source: Environmental Research - March 28, 2024 Category: Environmental Health Authors: N Prabhu Amal Abdullah A Sabour Sumathy Rengarajan K Gajendiran Devarajan Natarajan Source Type: research
Synthesis, antimicrobial, and in silico studies of c5'- < em > O < /em > -substituted cytidine derivatives: cinnamoylation leads to improvement of antimicrobial activity
In this study, cytidine (1) was first exposed to react with cinnamoyl chloride in N,N-dimethylformamide, and trimethylamine to obtain 5'-O-(cinnamoyl)cytidine, which was further treated with several acylating agents to obtain a series of 2',3'-di-O-acyl derivatives. The chemical structures of the synthesized compounds were established through spectral, analytical, and physicochemical techniques. In vitro antimicrobial efficacy was evaluated, and the antimicrobial effect was greater than that of the precursor compound; in particular, compound 3 exhibited the most promising activity. Cytotoxicity measurements revealed that t...
Source: Nucleosides, Nucleotides and Nucleic Acids - March 28, 2024 Category: Biochemistry Authors: Tahmida Sultana Bhuiyan Mohamed A Said Md Z H Bulbul Sumeer Ahmed Ajmal R Bhat Mohammed Chalkha Sarkar M A Kawsar Source Type: research
Unravelling the Antimicrobial, Antibiofilm, Suppressing < em > Fibronectin Binding Protein A < /em > ( < em > fnba < /em > ) and < em > cna < /em > Virulence Genes, Anti-Inflammatory and Antioxidant Potential of Biosynthesized < em > Solanum lycopersicum < /em > Silver Nanoparticles
Conclusions: The findings from this study indicate that biosynthesized AgNPs from Solanum lycopersicum exhibit promising antimicrobial and antioxidant properties against UTI pathogens, including strains resistant to multiple antibiotics. This suggests their potential as an effective alternative treatment for UTIs. Further research is warranted to fully understand the mechanisms of action and to explore the therapeutic applications of these nanoparticles in combating UTIs.PMID:38541241 | PMC:PMC10972527 | DOI:10.3390/medicina60030515 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alsayed E Mekky Ahmed E M Abdelaziz Fady Sayed Youssef Shymaa A Elaskary Aly A Shoun Eman A Alwaleed Mahmoud Ali Gaber Abdulaziz A Al-Askar Alhadary M Alsamman Abdullah Yousef Gehad AbdElgayed Reda A Suef Mohamed A Selim Ebrahim Saied Mohamed Khedr Source Type: research
Unravelling the Antimicrobial, Antibiofilm, Suppressing < em > Fibronectin Binding Protein A < /em > ( < em > fnba < /em > ) and < em > cna < /em > Virulence Genes, Anti-Inflammatory and Antioxidant Potential of Biosynthesized < em > Solanum lycopersicum < /em > Silver Nanoparticles
Conclusions: The findings from this study indicate that biosynthesized AgNPs from Solanum lycopersicum exhibit promising antimicrobial and antioxidant properties against UTI pathogens, including strains resistant to multiple antibiotics. This suggests their potential as an effective alternative treatment for UTIs. Further research is warranted to fully understand the mechanisms of action and to explore the therapeutic applications of these nanoparticles in combating UTIs.PMID:38541241 | PMC:PMC10972527 | DOI:10.3390/medicina60030515 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alsayed E Mekky Ahmed E M Abdelaziz Fady Sayed Youssef Shymaa A Elaskary Aly A Shoun Eman A Alwaleed Mahmoud Ali Gaber Abdulaziz A Al-Askar Alhadary M Alsamman Abdullah Yousef Gehad AbdElgayed Reda A Suef Mohamed A Selim Ebrahim Saied Mohamed Khedr Source Type: research
Unravelling the Antimicrobial, Antibiofilm, Suppressing < em > Fibronectin Binding Protein A < /em > ( < em > fnba < /em > ) and < em > cna < /em > Virulence Genes, Anti-Inflammatory and Antioxidant Potential of Biosynthesized < em > Solanum lycopersicum < /em > Silver Nanoparticles
Conclusions: The findings from this study indicate that biosynthesized AgNPs from Solanum lycopersicum exhibit promising antimicrobial and antioxidant properties against UTI pathogens, including strains resistant to multiple antibiotics. This suggests their potential as an effective alternative treatment for UTIs. Further research is warranted to fully understand the mechanisms of action and to explore the therapeutic applications of these nanoparticles in combating UTIs.PMID:38541241 | PMC:PMC10972527 | DOI:10.3390/medicina60030515 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alsayed E Mekky Ahmed E M Abdelaziz Fady Sayed Youssef Shymaa A Elaskary Aly A Shoun Eman A Alwaleed Mahmoud Ali Gaber Abdulaziz A Al-Askar Alhadary M Alsamman Abdullah Yousef Gehad AbdElgayed Reda A Suef Mohamed A Selim Ebrahim Saied Mohamed Khedr Source Type: research
Unravelling the Antimicrobial, Antibiofilm, Suppressing < em > Fibronectin Binding Protein A < /em > ( < em > fnba < /em > ) and < em > cna < /em > Virulence Genes, Anti-Inflammatory and Antioxidant Potential of Biosynthesized < em > Solanum lycopersicum < /em > Silver Nanoparticles
Conclusions: The findings from this study indicate that biosynthesized AgNPs from Solanum lycopersicum exhibit promising antimicrobial and antioxidant properties against UTI pathogens, including strains resistant to multiple antibiotics. This suggests their potential as an effective alternative treatment for UTIs. Further research is warranted to fully understand the mechanisms of action and to explore the therapeutic applications of these nanoparticles in combating UTIs.PMID:38541241 | PMC:PMC10972527 | DOI:10.3390/medicina60030515 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alsayed E Mekky Ahmed E M Abdelaziz Fady Sayed Youssef Shymaa A Elaskary Aly A Shoun Eman A Alwaleed Mahmoud Ali Gaber Abdulaziz A Al-Askar Alhadary M Alsamman Abdullah Yousef Gehad AbdElgayed Reda A Suef Mohamed A Selim Ebrahim Saied Mohamed Khedr Source Type: research
Unravelling the Antimicrobial, Antibiofilm, Suppressing < em > Fibronectin Binding Protein A < /em > ( < em > fnba < /em > ) and < em > cna < /em > Virulence Genes, Anti-Inflammatory and Antioxidant Potential of Biosynthesized < em > Solanum lycopersicum < /em > Silver Nanoparticles
Conclusions: The findings from this study indicate that biosynthesized AgNPs from Solanum lycopersicum exhibit promising antimicrobial and antioxidant properties against UTI pathogens, including strains resistant to multiple antibiotics. This suggests their potential as an effective alternative treatment for UTIs. Further research is warranted to fully understand the mechanisms of action and to explore the therapeutic applications of these nanoparticles in combating UTIs.PMID:38541241 | PMC:PMC10972527 | DOI:10.3390/medicina60030515 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alsayed E Mekky Ahmed E M Abdelaziz Fady Sayed Youssef Shymaa A Elaskary Aly A Shoun Eman A Alwaleed Mahmoud Ali Gaber Abdulaziz A Al-Askar Alhadary M Alsamman Abdullah Yousef Gehad AbdElgayed Reda A Suef Mohamed A Selim Ebrahim Saied Mohamed Khedr Source Type: research
Unravelling the Antimicrobial, Antibiofilm, Suppressing < em > Fibronectin Binding Protein A < /em > ( < em > fnba < /em > ) and < em > cna < /em > Virulence Genes, Anti-Inflammatory and Antioxidant Potential of Biosynthesized < em > Solanum lycopersicum < /em > Silver Nanoparticles
Conclusions: The findings from this study indicate that biosynthesized AgNPs from Solanum lycopersicum exhibit promising antimicrobial and antioxidant properties against UTI pathogens, including strains resistant to multiple antibiotics. This suggests their potential as an effective alternative treatment for UTIs. Further research is warranted to fully understand the mechanisms of action and to explore the therapeutic applications of these nanoparticles in combating UTIs.PMID:38541241 | PMC:PMC10972527 | DOI:10.3390/medicina60030515 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alsayed E Mekky Ahmed E M Abdelaziz Fady Sayed Youssef Shymaa A Elaskary Aly A Shoun Eman A Alwaleed Mahmoud Ali Gaber Abdulaziz A Al-Askar Alhadary M Alsamman Abdullah Yousef Gehad AbdElgayed Reda A Suef Mohamed A Selim Ebrahim Saied Mohamed Khedr Source Type: research
Unravelling the Antimicrobial, Antibiofilm, Suppressing < em > Fibronectin Binding Protein A < /em > ( < em > fnba < /em > ) and < em > cna < /em > Virulence Genes, Anti-Inflammatory and Antioxidant Potential of Biosynthesized < em > Solanum lycopersicum < /em > Silver Nanoparticles
Conclusions: The findings from this study indicate that biosynthesized AgNPs from Solanum lycopersicum exhibit promising antimicrobial and antioxidant properties against UTI pathogens, including strains resistant to multiple antibiotics. This suggests their potential as an effective alternative treatment for UTIs. Further research is warranted to fully understand the mechanisms of action and to explore the therapeutic applications of these nanoparticles in combating UTIs.PMID:38541241 | PMC:PMC10972527 | DOI:10.3390/medicina60030515 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alsayed E Mekky Ahmed E M Abdelaziz Fady Sayed Youssef Shymaa A Elaskary Aly A Shoun Eman A Alwaleed Mahmoud Ali Gaber Abdulaziz A Al-Askar Alhadary M Alsamman Abdullah Yousef Gehad AbdElgayed Reda A Suef Mohamed A Selim Ebrahim Saied Mohamed Khedr Source Type: research
Unravelling the Antimicrobial, Antibiofilm, Suppressing < em > Fibronectin Binding Protein A < /em > ( < em > fnba < /em > ) and < em > cna < /em > Virulence Genes, Anti-Inflammatory and Antioxidant Potential of Biosynthesized < em > Solanum lycopersicum < /em > Silver Nanoparticles
Conclusions: The findings from this study indicate that biosynthesized AgNPs from Solanum lycopersicum exhibit promising antimicrobial and antioxidant properties against UTI pathogens, including strains resistant to multiple antibiotics. This suggests their potential as an effective alternative treatment for UTIs. Further research is warranted to fully understand the mechanisms of action and to explore the therapeutic applications of these nanoparticles in combating UTIs.PMID:38541241 | PMC:PMC10972527 | DOI:10.3390/medicina60030515 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alsayed E Mekky Ahmed E M Abdelaziz Fady Sayed Youssef Shymaa A Elaskary Aly A Shoun Eman A Alwaleed Mahmoud Ali Gaber Abdulaziz A Al-Askar Alhadary M Alsamman Abdullah Yousef Gehad AbdElgayed Reda A Suef Mohamed A Selim Ebrahim Saied Mohamed Khedr Source Type: research
Unravelling the Antimicrobial, Antibiofilm, Suppressing < em > Fibronectin Binding Protein A < /em > ( < em > fnba < /em > ) and < em > cna < /em > Virulence Genes, Anti-Inflammatory and Antioxidant Potential of Biosynthesized < em > Solanum lycopersicum < /em > Silver Nanoparticles
Conclusions: The findings from this study indicate that biosynthesized AgNPs from Solanum lycopersicum exhibit promising antimicrobial and antioxidant properties against UTI pathogens, including strains resistant to multiple antibiotics. This suggests their potential as an effective alternative treatment for UTIs. Further research is warranted to fully understand the mechanisms of action and to explore the therapeutic applications of these nanoparticles in combating UTIs.PMID:38541241 | PMC:PMC10972527 | DOI:10.3390/medicina60030515 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alsayed E Mekky Ahmed E M Abdelaziz Fady Sayed Youssef Shymaa A Elaskary Aly A Shoun Eman A Alwaleed Mahmoud Ali Gaber Abdulaziz A Al-Askar Alhadary M Alsamman Abdullah Yousef Gehad AbdElgayed Reda A Suef Mohamed A Selim Ebrahim Saied Mohamed Khedr Source Type: research
Unravelling the Antimicrobial, Antibiofilm, Suppressing < em > Fibronectin Binding Protein A < /em > ( < em > fnba < /em > ) and < em > cna < /em > Virulence Genes, Anti-Inflammatory and Antioxidant Potential of Biosynthesized < em > Solanum lycopersicum < /em > Silver Nanoparticles
Conclusions: The findings from this study indicate that biosynthesized AgNPs from Solanum lycopersicum exhibit promising antimicrobial and antioxidant properties against UTI pathogens, including strains resistant to multiple antibiotics. This suggests their potential as an effective alternative treatment for UTIs. Further research is warranted to fully understand the mechanisms of action and to explore the therapeutic applications of these nanoparticles in combating UTIs.PMID:38541241 | PMC:PMC10972527 | DOI:10.3390/medicina60030515 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alsayed E Mekky Ahmed E M Abdelaziz Fady Sayed Youssef Shymaa A Elaskary Aly A Shoun Eman A Alwaleed Mahmoud Ali Gaber Abdulaziz A Al-Askar Alhadary M Alsamman Abdullah Yousef Gehad AbdElgayed Reda A Suef Mohamed A Selim Ebrahim Saied Mohamed Khedr Source Type: research
