Aspergillus fumigatus ctf1 –a novel zinc finger transcription factor involved in azole resistance
. (Source: Mycology)
Source: Mycology - April 24, 2024 Category: Biology Authors: Xiao GongHeng ZhangWenxu ChengZhangxuan HeTianyan MaTian ChenYi Suna Department of Dermatology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Chinab Department of Otolaryngology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou Source Type: research
An Analysis of the Contaminants on Otoscopes of Otolaryngology Residents: An Observational Study
This study was conducted in a medical teaching hospital in India. Total of 38 otoscopes of ENT residents were examined after taking samples using sterile cotton swabs from otoscope speculum and otoscope head and both bacterial and fungal culture were studied. The study showed that 11 otoscope heads (28.94%) and 11 otoscope speculums (28.94%) out of the 38 otoscopes studied showed bacterial growth. Most commonly isolated bacteria were skin commensals followed by Klebsiella species. Fungal growth was seen in 3 out of 38 otoscope Speculums (7.89%). All 3 fungi isolated during the study belonged to Aspergillus species. Trainin...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 23, 2024 Category: ENT & OMF Source Type: research
Allergen-specific immunotherapy for mold allergies
AbstractMolds are ubiquitous in our environment and are considered by the population to be the most important indoor pollutant problem [1]. The current 2023 update to the AWMF mold guideline [1] is intended to allay or channel fears and provide assistance for a sensible diagnosis and treatment decision.The detection of an IgE-mediated allergy implies for allergists Allergen immunotherapy (AIT) as an established treatment option. However, compared to the well-validated AIT with pollen and house dust mites, the decision to use AIT with mold extracts must be weighed more heavily between the benefits and risks.Spores ofAlter...
Source: Allergo Journal International - April 23, 2024 Category: Allergy & Immunology Source Type: research
Calcineurin-NFAT signaling controls neutrophils ´ ability of chemoattraction upon fungal infection
J Leukoc Biol. 2024 Apr 22:qiae091. doi: 10.1093/jleuko/qiae091. Online ahead of print.ABSTRACTCalcineurin - nuclear factor of activated T-cell (CN-NFAT) inhibitors are widely clinically used drugs for immunosuppression but besides their required T-cell response inhibition, they also undesirably affect innate immune cells. Disruption of innate immune cell function can explain the observed susceptibility of CN-NFAT inhibitors-treated patients to opportunistic fungal infections. Neutrophils play an essential role in innate immunity as a defense against pathogens, however, the effect of CN-NFAT inhibitors on neutrophil functi...
Source: Journal of Leukocyte Biology - April 22, 2024 Category: Hematology Authors: O Vymazal I Papatheodorou I Andrej činová V Bos áková G Vascelli K Bend íčková T Zelante M Hortov á-Kohoutková J Fri č Source Type: research
Evaluation of multi-heavy metal tolerance traits of soil-borne fungi for simultaneous removal of hazardous metals
The objective of the present study was to isolate the fungi from the agricultural soil of Kashmir valley, investigate their multi-metal tolerance to heavy metals and evaluate the metal uptake capacities of the resistant fungi. The fungi were isolated and identified on the basis of morphological and molecular approach (ITS1 and ITS4). The tolerance limits of the isolated fungal strains to various doses of lead (Pb), cadmium (Cd), zinc (Zn), chromium (Cr), copper (Cu), nickel (Ni), and cobalt (Co) was evaluated. Five fungal strains,Aspergillus niger, Fusarium oxysporum, Fusarium verticillioides,Aspergillus fischeri, Epicoccu...
Source: World Journal of Microbiology and Biotechnology - April 22, 2024 Category: Microbiology Source Type: research
Maize Aspergillus section Flavi isolate diversity may be distinct from that of soil and subsequently the source of aflatoxin contamination
AbstractAspergillus sectionFlavi (Flavi) is a diverse group of fungal species whose common members includeA. flavus andA. parasiticus. These are well-known for the production of aflatoxin (AF) B and G and other toxic metabolites, like cyclopiazonic acid (CPA). They are saprophytic soil dwellers and also become crop opportunistic epiphytes. The consequence is contamination of the crop with mycotoxins, such as carcinogenic AF. We investigated theFlavi community structure of maize and that of their surrounding soil, including their mycotoxigenicity. Furthermore, we investigated the link of the maizeFlavi diversity with prehar...
Source: Mycotoxin Research - April 22, 2024 Category: Toxicology Source Type: research
Green biocatalyst for decolorization of azo dyes from industrial wastewater: Coriolopsis trogii 2SMKN laccase immobilized on recycled brewer's spent grain
This study presents an innovative approach for the reuse and recycling of waste material, brewer's spent grain (BSG) for creating a novel green biocatalyst. The same BSG was utilized in several consecutive steps: initially, it served as a substrate for the cultivation and production of laccase by a novel isolated fungal strain, Coriolopsis trogii 2SMKN, then, it was reused as a carrier for laccase immobilization, aiding in the process of azo dye decolorization and finally, reused as recycled BSG for the second successful laccase immobilization for six guaiacol oxidation, contributing to a zero-waste strategy. The novel fun...
Source: Environmental Science and Pollution Research International - April 21, 2024 Category: Environmental Health Authors: Nevena Ili ć Sla đana Davidović Marija Mili ć Jelena La đarević Antonije Onjia Suzana Dimitrijevi ć-Branković Katarina Mihajlovski Source Type: research
Discovery of ( ±)-Penindolenes Reveals an Unusual Indole Ring Cleavage Pathway Catalyzed by P450 Monooxygenase
Angew Chem Int Ed Engl. 2024 Apr 18:e202403963. doi: 10.1002/anie.202403963. Online ahead of print.ABSTRACT(±)-Penindolenes A-D (1-4), the first representatives of indole terpenoids featuring a γ-lactam skeleton, were isolated from the mangrove-derived endophytic fungus Penicillium brocae MA-231. Our bioactivity tests revealed their potent antimicrobial and acetylcholinesterase inhibitory activities. The biosynthetic reactions by the five enzymes PbaABCDE leading to γ-lactam ring formation were identified with heterologous expression and in vitro enzymatic assays. Remarkably, the cytochrome P450 monooxygenase PbaB and i...
Source: Angewandte Chemie - April 18, 2024 Category: Chemistry Authors: Ling-Hong Meng Takayoshi Awakawa Xiao-Ming Li Zhiyang Quan Sui-Qun Yang Bin-Gui Wang Ikuro Abe Source Type: research
Malolactic fermentation in lingonberry juice and its use as a preservative
This study aimed to improve the taste of lingonberry juice by subjecting it to malolactic fermentation in order to reduce the sourness, and to investigate the benzoic acid in lingonberries as a natural preservative in juice blends by determining the microbial stability. After initial screening of lactic acid bacteria, a Lactiplantibacillus plantarum strain was used as the starter for subsequent investigations. Upon raising the pH, all malic acid was completely converted to lactic acid after seven days. The fermented juice was mixed with blackcurrant juice in different proportions. Challenge tests of the blends showed Liste...
Source: Food Microbiology - April 18, 2024 Category: Food Science Authors: Martina K Bergentall Jun Niimi Ingela Persson Emeline Calmet Dorine As Alexander Plovie Loredana Malafronte Petter Melin Source Type: research
Comparing resistance of bacterial spores and fungal conidia to pulsed light and UVC radiation at a wavelength of 254 nm
Food Microbiol. 2024 Aug;121:104518. doi: 10.1016/j.fm.2024.104518. Epub 2024 Mar 20.ABSTRACTPulsed light (PL) inactivates microorganisms by UV-rich, high-irradiance and short time pulses (250 μs) of white light with wavelengths from 200 nm to 1100 nm. PL is applied for disinfection of food packaging material and food-contact equipment. Spores of seven Bacillus ssp. strains and one Geobacillus stearothermophilus strain and conidia of filamentous fungi (One strain of Aspergillus brasiliensis, A. carbonarius and Penicillium rubens) were submitted to PL (fluence from 0.23 J/cm2 to 4.0 J/cm2) and UVC (at λ = 254 nm; fluence ...
Source: Food Microbiology - April 18, 2024 Category: Food Science Authors: Imed Dorbani Alain Berberian Christophe Riedel Catherine Duport Fr édéric Carlin Source Type: research
Synergistic antifungal mechanism of cinnamaldehyde and nonanal against Aspergillus flavus and its application in food preservation
Food Microbiol. 2024 Aug;121:104524. doi: 10.1016/j.fm.2024.104524. Epub 2024 Mar 25.ABSTRACTAspergillus flavus colonization on agricultural products during preharvest and postharvest results in tremendous economic losses. Inspired by the synergistic antifungal effects of essential oils, the aims of this study were to explore the mechanism of combined cinnamaldehyde and nonanal (SCAN) against A. flavus and to evaluate the antifungal activity of SCAN loading into diatomite (DM). Shriveled mycelia were observed by scanning electron microscopy, especially in the SCAN treatment group. Calcofluor white staining, transmission el...
Source: Food Microbiology - April 18, 2024 Category: Food Science Authors: Wei Zhang Cuixiang Li Yangyong Lv Shan Wei Yuansen Hu Source Type: research
Fungicidal efficiency of DBD cold plasma against Aspergillus niger on dried jujube
This study investigated the fungicidal efficiency and mechanism of action of dielectric barrier discharge cold atmosphere plasma (DBD-CAP) in inactivating Aspergillus niger (A. niger) spores. The disinfection efficacy and quality of dried jujube used as the processing application object were also studied. The results indicated that the Weibull + Tail model performed better for spore inactivation curves at different voltages among various treatment times, and the spore cells were reduced by 4.05 log (cfu/mL) in spores suspension at 70 kV after 15 min of treatment. This disinfection impact was further supported by scanning e...
Source: Food Microbiology - April 18, 2024 Category: Food Science Authors: Qiaoyun Wei Yuan Yuan Jianhao Zhang Jin Wang Source Type: research
Tragacanth gum-based copper oxide nanoparticles: Comprehensive characterization, antibiofilm, antimicrobial and photocatalytic potentials
In conclusion, the findings underline the promising multifunctional properties of TG-based CuO NPs for different practical applications.PMID:38631575 | DOI:10.1016/j.ijbiomac.2024.131600 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 17, 2024 Category: Biochemistry Authors: Sumayyah Ihsan Hira Munir Zihui Meng Muhammad Tayyab Nadia Zeeshan Ajwa Rehman Sawaira Nadeem Muhammad Irfan Source Type: research
Four sulfur-containing compounds with effect from marine-derived fungus aspergillus terreus
In this study, four previously undescribed sulfur-containing compounds asperteretals L and M, terreins A and B, together with 17 known compounds were obtained from a culture of marine fungus A. terreus supplemented with inorganic sulfur source Na2SO4. Their planar structures and absolute configurations were elucidated by NMR, HRESIMS, and ECD experiments. The in vitro cytotoxicities of compounds 1-21 against HCT-116 and Caco-2 were evaluated by SRB assay. Asperteretal M (2) exhibited activity against HCT-116 with the IC50 value at 30 μM. The antiproliferative effect of asperteretal M was confirmed by colony formation assa...
Source: Fitoterapia - April 17, 2024 Category: Biochemistry Authors: Guang-Yu Zhang Bei-Jia Liu Hui-Lin Pan Hou-Jin Li Zi-Feng Huang Taifo Mahmud Wen-Zhe Ma Wen-Jian Lan Source Type: research
Antimicrobial secondary metabolites and antioxidant activities of fungal endophytes associated with < em > Ziziphus spina-christi < /em > (L.) Desf. (Nabq) leaves
This study would be one of the first reports to measure the antioxidant activity of Z. spina-christi (L.) Desf. endophytic fungi. Therefore, these isolated endophytic fungi can provide additional information for medicinal sources of natural antioxidants and antimicrobial agents.PMID:38630967 | DOI:10.1080/14786419.2024.2340761 (Source: Natural Product Research)
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Hala Montaser Farouk Eman Zekry Attia Gehan Mohamed Shaban Usama Ramadan Abdelmohsen Mo'men Hamed El-Katatny Source Type: research
