Mycoremediation of the novel fungicide ametoctradin by different agricultural soils and accelerated degradation utilizing selected fungal strains
In conclusion, soil rich in microorganisms effectively cleans Ametoctradin-contaminated areas while Fungi have also been shown to be an effective, affordable, and promising way to remove Ametoctradin from the environment.PMID:38534106 | DOI:10.1080/03601234.2024.2331951 (Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes)
Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes - March 27, 2024 Category: Environmental Health Authors: Sara Majid Khuram Shahzad Ahmad Ghulam Abbas Ashraf Wahidah H Al-Qahtani Source Type: research

Mycoremediation of the novel fungicide ametoctradin by different agricultural soils and accelerated degradation utilizing selected fungal strains
In conclusion, soil rich in microorganisms effectively cleans Ametoctradin-contaminated areas while Fungi have also been shown to be an effective, affordable, and promising way to remove Ametoctradin from the environment.PMID:38534106 | DOI:10.1080/03601234.2024.2331951 (Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes)
Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes - March 27, 2024 Category: Environmental Health Authors: Sara Majid Khuram Shahzad Ahmad Ghulam Abbas Ashraf Wahidah H Al-Qahtani Source Type: research

Mycoremediation of the novel fungicide ametoctradin by different agricultural soils and accelerated degradation utilizing selected fungal strains
In conclusion, soil rich in microorganisms effectively cleans Ametoctradin-contaminated areas while Fungi have also been shown to be an effective, affordable, and promising way to remove Ametoctradin from the environment.PMID:38534106 | DOI:10.1080/03601234.2024.2331951 (Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes)
Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes - March 27, 2024 Category: Environmental Health Authors: Sara Majid Khuram Shahzad Ahmad Ghulam Abbas Ashraf Wahidah H Al-Qahtani Source Type: research

Mycoremediation of the novel fungicide ametoctradin by different agricultural soils and accelerated degradation utilizing selected fungal strains
In conclusion, soil rich in microorganisms effectively cleans Ametoctradin-contaminated areas while Fungi have also been shown to be an effective, affordable, and promising way to remove Ametoctradin from the environment.PMID:38534106 | DOI:10.1080/03601234.2024.2331951 (Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes)
Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes - March 27, 2024 Category: Environmental Health Authors: Sara Majid Khuram Shahzad Ahmad Ghulam Abbas Ashraf Wahidah H Al-Qahtani Source Type: research

Mycoremediation of the novel fungicide ametoctradin by different agricultural soils and accelerated degradation utilizing selected fungal strains
In conclusion, soil rich in microorganisms effectively cleans Ametoctradin-contaminated areas while Fungi have also been shown to be an effective, affordable, and promising way to remove Ametoctradin from the environment.PMID:38534106 | DOI:10.1080/03601234.2024.2331951 (Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes)
Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes - March 27, 2024 Category: Environmental Health Authors: Sara Majid Khuram Shahzad Ahmad Ghulam Abbas Ashraf Wahidah H Al-Qahtani Source Type: research

Mycoremediation of the novel fungicide ametoctradin by different agricultural soils and accelerated degradation utilizing selected fungal strains
In conclusion, soil rich in microorganisms effectively cleans Ametoctradin-contaminated areas while Fungi have also been shown to be an effective, affordable, and promising way to remove Ametoctradin from the environment.PMID:38534106 | DOI:10.1080/03601234.2024.2331951 (Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes)
Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes - March 27, 2024 Category: Environmental Health Authors: Sara Majid Khuram Shahzad Ahmad Ghulam Abbas Ashraf Wahidah H Al-Qahtani Source Type: research

Mycoremediation of the novel fungicide ametoctradin by different agricultural soils and accelerated degradation utilizing selected fungal strains
In conclusion, soil rich in microorganisms effectively cleans Ametoctradin-contaminated areas while Fungi have also been shown to be an effective, affordable, and promising way to remove Ametoctradin from the environment.PMID:38534106 | DOI:10.1080/03601234.2024.2331951 (Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes)
Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes - March 27, 2024 Category: Environmental Health Authors: Sara Majid Khuram Shahzad Ahmad Ghulam Abbas Ashraf Wahidah H Al-Qahtani Source Type: research

Synthesis and antifungal activity of hexahydropyrrolidoindole alkaloids
Nat Prod Res. 2024 Mar 26:1-9. doi: 10.1080/14786419.2024.2333047. Online ahead of print.ABSTRACTTwenty-one hexahydropyrrolidoindole alkaloids were designed and synthesised via acylation reaction at the 3-N position from the commercially available indole-3-acetonitrile as the starting material in excellent yields. The effects of all target compounds against Verticillium dahlia, Fusarium oxysperium sp., Cytospora juglandis, Aspergillu sflavu, Aspergillus niger and Fusarium oxysporum were determined. The results of bioassays indicated that the majority of tested compounds displayed comparable or better in vitro bioactivity t...
Source: Natural Product Research - March 26, 2024 Category: Biochemistry Authors: Yujie Zhou Shoude Ma Xiaohan Li Xinye Liu Jie Gao Dingding L ü Ya Wang Shaojun Zheng Source Type: research

Biochemical characterization of a multiple prenyltransferase from Tolypocladium inflatum
This study presents the functional characterization of TolF, a multiple prenyltransferase from Tolypocladium inflatum. The heterologous expression of tolF in Aspergillus oryzae, coupled with feeding the transformed strain with paxilline, resulted in the production of 20- and 22-prenylpaxilline. Additionally, TolF demonstrated the ability to prenylated the reduced form of paxilline, β-paxitriol. A related prenyltransferase TerF from Chaunopycnis alba, exhibited similar substrate tolerance and regioselectivity. In vitro enzyme assays using purified recombinant enzymes TolF and TerF confirmed their capacity to catalyze preny...
Source: Applied Microbiology and Biotechnology - March 26, 2024 Category: Microbiology Authors: Haiyan Han Shuang Peng Qian Wang Hongwei Wang Pengchao Wang Chang Li Jianzhao Qi Chengwei Liu Source Type: research

Aberrant Glycosylation in Pancreatic Ductal Adenocarcinoma 3D Organoids Is Mediated by KRAS Mutations
J Oncol. 2024 Mar 18;2024:1529449. doi: 10.1155/2024/1529449. eCollection 2024.ABSTRACTAberrant glycosylation in tumor cells is a hallmark during carcinogenesis. KRAS gene mutations are the most well-known oncogenic abnormalities but their association with glycan alterations in pancreatic ductal adenocarcinoma (PDAC) is largely unknown. We employed patient-derived 3D organoids to culture pure live PDAC cells, excluding contamination by fibroblasts and immune cells, to gasp the comprehensive cancer cell surface glycan expression profile using lectin microarray and transcriptomic analyses. Surgical specimens from 24 PDAC pat...
Source: Journal of Oncology - March 26, 2024 Category: Cancer & Oncology Authors: Hiromitsu Nakahashi Tatsuya Oda Osamu Shimomura Yoshimasa Akashi Kazuhiro Takahashi Yoshihiro Miyazaki Tomoaki Furuta Yukihito Kuroda Pakavarin Louphrasitthiphol Bryan J Mathis Hiroaki Tateno Source Type: research

Synthesis and antifungal activity of hexahydropyrrolidoindole alkaloids
Nat Prod Res. 2024 Mar 26:1-9. doi: 10.1080/14786419.2024.2333047. Online ahead of print.ABSTRACTTwenty-one hexahydropyrrolidoindole alkaloids were designed and synthesised via acylation reaction at the 3-N position from the commercially available indole-3-acetonitrile as the starting material in excellent yields. The effects of all target compounds against Verticillium dahlia, Fusarium oxysperium sp., Cytospora juglandis, Aspergillu sflavu, Aspergillus niger and Fusarium oxysporum were determined. The results of bioassays indicated that the majority of tested compounds displayed comparable or better in vitro bioactivity t...
Source: Natural Product Research - March 26, 2024 Category: Biochemistry Authors: Yujie Zhou Shoude Ma Xiaohan Li Xinye Liu Jie Gao Dingding L ü Ya Wang Shaojun Zheng Source Type: research

Biochemical characterization of a multiple prenyltransferase from Tolypocladium inflatum
This study presents the functional characterization of TolF, a multiple prenyltransferase from Tolypocladium inflatum. The heterologous expression of tolF in Aspergillus oryzae, coupled with feeding the transformed strain with paxilline, resulted in the production of 20- and 22-prenylpaxilline. Additionally, TolF demonstrated the ability to prenylated the reduced form of paxilline, β-paxitriol. A related prenyltransferase TerF from Chaunopycnis alba, exhibited similar substrate tolerance and regioselectivity. In vitro enzyme assays using purified recombinant enzymes TolF and TerF confirmed their capacity to catalyze preny...
Source: Applied Microbiology and Biotechnology - March 26, 2024 Category: Microbiology Authors: Haiyan Han Shuang Peng Qian Wang Hongwei Wang Pengchao Wang Chang Li Jianzhao Qi Chengwei Liu Source Type: research

Aberrant Glycosylation in Pancreatic Ductal Adenocarcinoma 3D Organoids Is Mediated by KRAS Mutations
J Oncol. 2024 Mar 18;2024:1529449. doi: 10.1155/2024/1529449. eCollection 2024.ABSTRACTAberrant glycosylation in tumor cells is a hallmark during carcinogenesis. KRAS gene mutations are the most well-known oncogenic abnormalities but their association with glycan alterations in pancreatic ductal adenocarcinoma (PDAC) is largely unknown. We employed patient-derived 3D organoids to culture pure live PDAC cells, excluding contamination by fibroblasts and immune cells, to gasp the comprehensive cancer cell surface glycan expression profile using lectin microarray and transcriptomic analyses. Surgical specimens from 24 PDAC pat...
Source: Journal of Oncology - March 26, 2024 Category: Cancer & Oncology Authors: Hiromitsu Nakahashi Tatsuya Oda Osamu Shimomura Yoshimasa Akashi Kazuhiro Takahashi Yoshihiro Miyazaki Tomoaki Furuta Yukihito Kuroda Pakavarin Louphrasitthiphol Bryan J Mathis Hiroaki Tateno Source Type: research