Molecules, Vol. 28, Pages 4329: Oleanolic Acid Glycosides from Scabiosa caucasica and Scabiosa ochroleuca: Structural Analysis and Cytotoxicity
e Mitaine-Offer
In the field of research on medicinal plants from the Armenian flora, the phytochemical study of two Scabiosa L. species, S. caucasica M. Bieb. and S. ochroleuca L. (Caprifoliaceae), has led to the isolation of five previously undescribed oleanolic acid glycosides from an aqueous-ethanolic extract of the roots: 3-O-α-L-rhamnopyranosyl-(1→3)-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosylo...
Source: Molecules - May 25, 2023 Category: Chemistry Authors: Samvel Nazaryan Antoine Brugui ère Nelli Hovhannisyan Tomofumi Miyamoto Alexandre M. M. Dias Pierre-Simon Bellaye Bertrand Collin Lo ïc Briand Anne-Claire Mitaine-Offer Tags: Article Source Type: research
Temporal trends of tracheal, bronchus, and lung cancer between 2010 and 2019, in Asian countries by geographical region and sociodemographic index, comparison with global data
ConclusionMost of the global burden of lung cancer occurs in Asian countries, and the decreasing trend of incidence, death, prevalence, and burden of this cancer in these countries is slower than in other regions. Therefore, the implementation of necessary measures in order to reduce the process of this cancer is considered urgent. (Source: Thoracic Cancer)
Source: Thoracic Cancer - May 2, 2023 Category: Cancer & Oncology Authors: Fatemeh Rezaei,
Afrooz Mazidimoradi,
Ali Rayatinejad,
Leila Allahqoli,
Hamid Salehiniya Tags: ORIGINAL ARTICLE Source Type: research
Feasibility of implementing a supervised telehealth exercise intervention in frail survivors of hematopoietic cell transplantation: a pilot randomized trial
CONCLUSION: Implementing an 8-week telehealth exercise intervention for long-term HCT survivors was feasible. Our findings set the stage for innovative delivery of supervised exercise intervention that reduces the burden of frailty in HCT survivors as well as other at-risk cancer survivors.TRIAL REGISTRATION: The protocol and informed consent were approved by the institutional IRB (IRB#20731) and registered (ClinicalTrials.gov NCT04968119; date of registration: 20/07/2021).PMID:37127595 | DOI:10.1186/s12885-023-10884-5 (Source: Cancer Control)
Source: Cancer Control - May 1, 2023 Category: Cancer & Oncology Authors: Kyuwan Lee Justin Shamunee Lanie Lindenfeld Elizabeth Ross Lindsey Hageman Mina S Sedrak F Lennie Wong Ryotaro Nakamura Stephen J Forman Smita Bhatia Saro H Armenian Source Type: research
Cardiac Disease in Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review
CONCLUSIONS: Radiation dose to the heart increases the risk of late cardiac disease, but survivors of childhood cancer who receive a mean dose <10 Gy at standard fractionation are at low absolute risk (<∼2% approximately 30 years after exposure) of late cardiac disease in the absence of anthracycline exposure. Minimizing cardiac radiation dose is especially relevant in children receiving anthracyclines. When cardiac sparing is not possible, we recommend prioritizing target coverage. It is likely that individual cardiac substructure doses will be a better predictor of specific cardiac diseases than mean dose, and we...
Source: Health Physics - April 16, 2023 Category: Physics Authors: James E Bates Tiziana Rancati Homa Keshavarz Giovanna Gagliardi Marianne C Aznar Rebecca M Howell Suman Shrestha Vitali Moiseenko Ellen Yorke Saro Armenian Leontien Kremer Ming Hui Chen Helena J van der Pal David J Cutter Louis S Constine David Hodgson Source Type: research
Cardiac Disease in Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review
CONCLUSIONS: Radiation dose to the heart increases the risk of late cardiac disease, but survivors of childhood cancer who receive a mean dose <10 Gy at standard fractionation are at low absolute risk (<∼2% approximately 30 years after exposure) of late cardiac disease in the absence of anthracycline exposure. Minimizing cardiac radiation dose is especially relevant in children receiving anthracyclines. When cardiac sparing is not possible, we recommend prioritizing target coverage. It is likely that individual cardiac substructure doses will be a better predictor of specific cardiac diseases than mean dose, and we...
Source: Health Physics - April 16, 2023 Category: Physics Authors: James E Bates Tiziana Rancati Homa Keshavarz Giovanna Gagliardi Marianne C Aznar Rebecca M Howell Suman Shrestha Vitali Moiseenko Ellen Yorke Saro Armenian Leontien Kremer Ming Hui Chen Helena J van der Pal David J Cutter Louis S Constine David Hodgson Source Type: research
Cardiac Disease in Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review
Radiation therapy (RT) is an essential component in the treatment of many pediatric malignancies. Thoracic RT may expose the heart to radiation dose and thereby increase the risk of late cardiac disease. This comprehensive review from the Pediatric Normal Tissue Effects in the Clinic (PENTEC) initiative focused on late cardiac disease in survivors of childhood cancer treated with RT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 14, 2023 Category: Radiology Authors: James E. Bates, Tiziana Rancati, Homa Keshavarz, Giovanna Gagliardi, Marianne C. Aznar, Rebecca M. Howell, Suman Shrestha, Vitali Moiseenko, Ellen Yorke, Saro Armenian, Leontien Kremer, Ming Hui Chen, Helena J. van der Pal, David J. Cutter, Louis S. Const Tags: CLINICAL INVESTIGATION Source Type: research
Change in global burden of unintentional drowning from 1990 to 2019 and its association with social determinants of health: findings from the Global Burden of Disease Study 2019
Conclusions
The global burden of unintentional drowning significantly declined in the past three decades, and the improvement of SDHs such as GDP per capita and health spending mainly contributed to the decrease. Our findings indicate that improvement of SDHs is critical for drowning prevention and control. (Source: BMJ Open)
Source: BMJ Open - April 12, 2023 Category: General Medicine Authors: Tan, H., Lin, Z., Fu, D., Dong, X., Zhu, S., Huang, Z., Liu, Y., He, G., Yang, P., Liu, T., Ma, W. Tags: Open access, Epidemiology Source Type: research
Deep phenotype characterization of hypertensive response to exercise: implications on functional capacity and prognosis across the heart failure spectrum
ConclusionA steeper SBP/workload slope is associated with impaired functional capacity across the HF spectrum and could be a more sensitive predictor of adverse events than absolute SBP values, mainly in patients in Stages A –B and HFpEF. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - March 30, 2023 Category: Cardiology Authors: Nicola Riccardo Pugliese,
Nicol ò De Biase,
Lavinia Del Punta,
Alessio Balletti,
Silvia Armenia,
Simona Buralli,
Alessandro Mengozzi,
Stefano Taddei,
Marco Metra,
Matteo Pagnesi,
Barry A. Borlaug,
Bryan Williams,
Stefano Masi Tags: Research Article Source Type: research
Host genetics and gut microbiota composition: Baseline gut microbiota composition as a possible prognostic factor for the severity of COVID-19 in patients with familial Mediterranean fever disease
BackgroundIt is known that the gut microbiome of a healthy person affects the process of COVID-19 after getting infected with SARS-CoV-2 virus. It is also believed that colchicine can alleviate the severity of COVID-19.ObjectiveCurrent investigations aimed to evaluate the associations between the baseline gut microbiota composition of healthy and Familial Mediterranean fever (FMF) - carrier Armenian men populations, and the severity of the COVID-19 disease after their infection with the SARS-CoV-2. The study has a purpose of answering three core questions: i. Do the characteristics of gut microbiome of Armenians affect the...
Source: Frontiers in Microbiology - March 30, 2023 Category: Microbiology Source Type: research
Lung Cancer in Armenia
J Thorac Oncol. 2023 Apr;18(4):402-409. doi: 10.1016/j.jtho.2022.12.015.NO ABSTRACTPMID:36990573 | DOI:10.1016/j.jtho.2022.12.015 (Source: Ann Oncol)
Source: Ann Oncol - March 29, 2023 Category: Cancer & Oncology Authors: Davit Zohrabyan Nune Karapetyan Samvel Danielyan Tatul Saghatelyan Liana Safaryan Samvel Bardakhchyan Gevorg Tamamyan Martin Harutyunyan Marine Rushanyan Gohar Mkrtchyan Sergey Badalyan Armen Avagyan Lilit Harutyunyan Armine Lazaryan Sergey Mkhitaryan Arm Source Type: research
Lung Cancer in Armenia
J Thorac Oncol. 2023 Apr;18(4):402-409. doi: 10.1016/j.jtho.2022.12.015.NO ABSTRACTPMID:36990573 | DOI:10.1016/j.jtho.2022.12.015 (Source: Ann Oncol)
Source: Ann Oncol - March 29, 2023 Category: Cancer & Oncology Authors: Davit Zohrabyan Nune Karapetyan Samvel Danielyan Tatul Saghatelyan Liana Safaryan Samvel Bardakhchyan Gevorg Tamamyan Martin Harutyunyan Marine Rushanyan Gohar Mkrtchyan Sergey Badalyan Armen Avagyan Lilit Harutyunyan Armine Lazaryan Sergey Mkhitaryan Arm Source Type: research
