The trends in death of primary liver cancer caused by specific etiologies worldwide: results from the Global Burden of Disease Study 2019 and implications for liver cancer management
CONCLUSION: From 1990 to 2019, there was a worldwide decrease in deaths caused by liver cancer and its underlying causes. However, rising tendencies have been observed in low-resource regions and countries. The trends in drug use- and high BMI-related death from liver cancer and its underlying etiologies were concerning. The findings indicated that efforts should be increased to prevent liver cancer deaths through improved etiology control and risk management.PMID:37380957 | DOI:10.1186/s12885-023-11038-3 (Source: Cancer Control)
Source: Cancer Control - June 28, 2023 Category: Cancer & Oncology Authors: Yongzhi Li Zejin Ou Danfeng Yu Huan He Liting Zheng Jiaqi Chen Caiyun Chen Hushen Xiong Qing Chen Source Type: research
Remote Activation of Enzyme Nanohybrids for Cancer Prodrug Therapy Controlled by Magnetic Heating
ACS Nano. 2023 Jun 26. doi: 10.1021/acsnano.3c01599. Online ahead of print.ABSTRACTHerein, we have developed nanohybrids (nHs) to remotely activate a therapeutic enzyme for its use in Directed Enzyme Prodrug Therapy (DEPT). The coencapsulation of magnetic nanoparticles (MNPs) with horseradish peroxidase (HRP) using biomimetic silica as an entrapment matrix was optimized to obtain nanosized hybrids (∼150 nm) for remote activation of the therapeutic enzyme. HRP converts indole-3-acetic acid (3IAA) into peroxylated radicals, whereas MNPs respond to alternating magnetic fields (AMFs) becoming local hotspots. The AMF applicat...
Source: Cancer Control - June 26, 2023 Category: Cancer & Oncology Authors: Beatriz Torres-Herrero Ilaria Armenia Maria Alleva Laura As ín Sonali Correa Cecilia Ortiz Yilian Fern ández-Afonso Luc ía Gutiérrez Jes ús M de la Fuente Lorena Betancor Valeria Graz ú Source Type: research
[ASAP] Remote Activation of Enzyme Nanohybrids for Cancer Prodrug Therapy Controlled by Magnetic Heating
ACS NanoDOI: 10.1021/acsnano.3c01599 (Source: ACS Nano)
Source: ACS Nano - June 26, 2023 Category: Nanotechnology Authors: Beatriz Torres-Herrero, Ilaria Armenia, Maria Alleva, Laura Asi ́n, Sonali Correa, Cecilia Ortiz, Yilian Fernández-Afonso, Lucía Gutiérrez, Jesús M. de la Fuente, Lorena Betancor, and Valeria Grazú Source Type: research
Generation of three induced pluripotent stem cell lines (RAUi001-A, RAUi001-B and RAUi001-C) from peripheral blood mononuclear cells of a healthy Armenian individual
Stem Cell Res. 2023 Jun 17;71:103147. doi: 10.1016/j.scr.2023.103147. Online ahead of print.ABSTRACTThe study of pathological processes in cells carrying mutations should be carried out in comparison with a healthy control group. Familial Mediterranean fever (FMF), which is caused by a mutation in the MEFV gene, is predominantly found in people of Armenian nationality with the prevalence of 14-100 per 10000. We have obtained induced pluripotent stem cells (iPSCs) from Armenian healthy patient, which will be included as a control group in the study of this disease. iPSCs rapidly proliferate in colonies of cells with a typic...
Source: Cell Research - June 24, 2023 Category: Cytology Authors: Elena V Grigor'eva Anastasia A Malakhova Lilit Ghukasyan Varduhi Hayrapetyan Sofi Atshemyan Valentina Vardanyan Suren M Zakian Roksana Zakharyan Arsen Arakelyan Source Type: research
The spatiotemporal variation, background, and baseline activities of radionuclides in the soil of Aragats Massif (Armenia)
Environ Sci Pollut Res Int. 2023 Jun 17. doi: 10.1007/s11356-023-28231-3. Online ahead of print.ABSTRACTThe present study was performed to reveal the distribution patterns and spatiotemporal changes of radionuclides in the soil of the highest mountain of Armenia: Aragats Massif. In this regard, two surveys were implemented in 2016-2018 and 2021 with an altitudinal sampling strategy. The activities of radionuclides were determined by gamma spectrometry system with HPGe detector (CANBERRA). Correlation and linear regression analysis were applied to determine the dependence of radionuclides' distribution from altitude. Classi...
Source: Environmental Science and Pollution Research International - June 17, 2023 Category: Environmental Health Authors: Nona Movsisyan Stefano Albanese Konstantin Pyuskyulyan Spartak Hovhannisyan Olga Belyaeva Source Type: research
The spatiotemporal variation, background, and baseline activities of radionuclides in the soil of Aragats Massif (Armenia)
Environ Sci Pollut Res Int. 2023 Jun 17. doi: 10.1007/s11356-023-28231-3. Online ahead of print.ABSTRACTThe present study was performed to reveal the distribution patterns and spatiotemporal changes of radionuclides in the soil of the highest mountain of Armenia: Aragats Massif. In this regard, two surveys were implemented in 2016-2018 and 2021 with an altitudinal sampling strategy. The activities of radionuclides were determined by gamma spectrometry system with HPGe detector (CANBERRA). Correlation and linear regression analysis were applied to determine the dependence of radionuclides' distribution from altitude. Classi...
Source: Environmental Science and Pollution Research International - June 17, 2023 Category: Environmental Health Authors: Nona Movsisyan Stefano Albanese Konstantin Pyuskyulyan Spartak Hovhannisyan Olga Belyaeva Source Type: research
Lung cancer screening beliefs in Armenia
This study employed a rigorously-translated, previously-validated survey based on the Expanded Health Belief Model to understand how Armenian male smokers’ beliefs would affect lung cancer screening participation.ResultsSurvey responses highlighted key health beliefs that would mediate screening participation. Most respondents felt they were at risk for lung cancer, but over 50% also believed their cancer risk was equivalent to (or less than) non-smokers’ risk. Respondents also overwhelmingly agreed a scan could help detect cancer earlier, but fewer agreed early detection could reduce cancer mortality. Important barrie...
Source: Frontiers in Oncology - June 16, 2023 Category: Cancer & Oncology Source Type: research
Conditional survival and standardized mortality ratios of patients with severe aplastic anemia surviving at least one year after hematopoietic cell transplantation or immunosuppressive therapy
We report on conditional survival and standardized mortality ratios (SMR), which compares the mortality risk with the general population adjusted for age, gender, and race/ethnicity, in patients with SAA alive for at least 12 months after treatment with IST or HCT between 2000 and 2018. Two treatment periods were defined a priori (2000-2010, 2011-2018), given changes to treatment regimens and differences in length of follow-up. The SMRs of patients treated during the period 2000-2010 and survived 1 year were 3.50 (95% confidence interval [CI]: 2.62-4.58), 4.12 (95% CI 3.20-5.21), and 8.62 (95% CI 6.88-10.67) after IST, mat...
Source: Haematologica - June 1, 2023 Category: Hematology Authors: Ryotaro Nakamura Bhavisha A Patel Soyoung Kim F Lennie Wong Saro H Armenian Emma M Groarke Daniel A Kessler Kyle M Hebert Michael Heim Mary Eapen Neal S Young Source Type: research
Conditional survival and standardized mortality ratios of patients with severe aplastic anemia surviving at least one year after hematopoietic cell transplantation or immunosuppressive therapy
We report on conditional survival and standardized mortality ratios (SMR), which compares the mortality risk with the general population adjusted for age, gender, and race/ethnicity, in patients with SAA alive for at least 12 months after treatment with IST or HCT between 2000 and 2018. Two treatment periods were defined a priori (2000-2010, 2011-2018), given changes to treatment regimens and differences in length of follow-up. The SMRs of patients treated during the period 2000-2010 and survived 1 year were 3.50 (95% confidence interval [CI]: 2.62-4.58), 4.12 (95% CI 3.20-5.21), and 8.62 (95% CI 6.88-10.67) after IST, mat...
Source: Haematologica - June 1, 2023 Category: Hematology Authors: Ryotaro Nakamura Bhavisha A Patel Soyoung Kim F Lennie Wong Saro H Armenian Emma M Groarke Daniel A Kessler Kyle M Hebert Michael Heim Mary Eapen Neal S Young Source Type: research
Conditional survival and standardized mortality ratios of patients with severe aplastic anemia surviving at least one year after hematopoietic cell transplantation or immunosuppressive therapy
We report on conditional survival and standardized mortality ratios (SMR), which compares the mortality risk with the general population adjusted for age, gender, and race/ethnicity, in patients with SAA alive for at least 12 months after treatment with IST or HCT between 2000 and 2018. Two treatment periods were defined a priori (2000-2010, 2011-2018), given changes to treatment regimens and differences in length of follow-up. The SMRs of patients treated during the period 2000-2010 and survived 1 year were 3.50 (95% confidence interval [CI]: 2.62-4.58), 4.12 (95% CI 3.20-5.21), and 8.62 (95% CI 6.88-10.67) after IST, mat...
Source: Haematologica - June 1, 2023 Category: Hematology Authors: Ryotaro Nakamura Bhavisha A Patel Soyoung Kim F Lennie Wong Saro H Armenian Emma M Groarke Daniel A Kessler Kyle M Hebert Michael Heim Mary Eapen Neal S Young Source Type: research
Conditional survival and standardized mortality ratios of patients with severe aplastic anemia surviving at least one year after hematopoietic cell transplantation or immunosuppressive therapy
We report on conditional survival and standardized mortality ratios (SMR), which compares the mortality risk with the general population adjusted for age, gender, and race/ethnicity, in patients with SAA alive for at least 12 months after treatment with IST or HCT between 2000 and 2018. Two treatment periods were defined a priori (2000-2010, 2011-2018), given changes to treatment regimens and differences in length of follow-up. The SMRs of patients treated during the period 2000-2010 and survived 1 year were 3.50 (95% confidence interval [CI]: 2.62-4.58), 4.12 (95% CI 3.20-5.21), and 8.62 (95% CI 6.88-10.67) after IST, mat...
Source: Haematologica - June 1, 2023 Category: Hematology Authors: Ryotaro Nakamura Bhavisha A Patel Soyoung Kim F Lennie Wong Saro H Armenian Emma M Groarke Daniel A Kessler Kyle M Hebert Michael Heim Mary Eapen Neal S Young Source Type: research
Conditional survival and standardized mortality ratios of patients with severe aplastic anemia surviving at least one year after hematopoietic cell transplantation or immunosuppressive therapy
We report on conditional survival and standardized mortality ratios (SMR), which compares the mortality risk with the general population adjusted for age, gender, and race/ethnicity, in patients with SAA alive for at least 12 months after treatment with IST or HCT between 2000 and 2018. Two treatment periods were defined a priori (2000-2010, 2011-2018), given changes to treatment regimens and differences in length of follow-up. The SMRs of patients treated during the period 2000-2010 and survived 1 year were 3.50 (95% confidence interval [CI]: 2.62-4.58), 4.12 (95% CI 3.20-5.21), and 8.62 (95% CI 6.88-10.67) after IST, mat...
Source: Haematologica - June 1, 2023 Category: Hematology Authors: Ryotaro Nakamura Bhavisha A Patel Soyoung Kim F Lennie Wong Saro H Armenian Emma M Groarke Daniel A Kessler Kyle M Hebert Michael Heim Mary Eapen Neal S Young Source Type: research
HPV Vaccination and Cervical Cancer Screening Policies and Practices in 18 Countries, Territories and Entities across Eastern Europe and Central Asia
CONCLUSIONS: Cervical cancer prevention services in this region are very limited. Achieving the WHO Global Strategy targets by 2030 will require substantial investments in capacity building by international development organisations.PMID:37247301 | DOI:10.31557/APJCP.2023.24.5.1781 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - May 29, 2023 Category: Cancer & Oncology Authors: Philip Davies Igor Aluloski Diyora Aluloski Jelena Brcanski Aliaksandr Davidzenka Akjemal Durdyeva Saida Gayrat Umarzoda Kemal Goshliyev Verica Jovanovic Levan Jugeli Merita Kocinaj-Berisha Galina Maistruk Tamara Naumovic Aida Pilav Gulnara Rzayeva Karine Source Type: research
