Identification of novel hypermethylated or hypomethylated CpG sites and genes associated with anthracycline-induced cardiomyopathy
This report used participants from a matched case-control study; 52 non-Hispanic White, anthracycline-exposed childhood cancer survivors with cardiomyopathy were matched 1:1 with 52 survivors with no cardiomyopathy. Paired ChAMP (Chip Analysis Methylation Pipeline) with integrated reference-based deconvolution of adult peripheral blood DNA methylation was used to analyze data from Illumina HumanMethylation EPIC BeadChip arrays. An epigenome-wide association study (EWAS) was performed, and the model was adjusted for GrimAge, sex, interaction terms of age at enrollment, chest radiation, age at diagnosis squared, and cardiova...
Source: Cancer Control - August 4, 2023 Category: Cancer & Oncology Authors: Purnima Singh Liting Zhou Disheet A Shah Romina B Cejas David K Crossman Mariam Jouni Tarek Magdy Xuexia Wang Noha Sharafeldin Lindsey Hageman Donald E McKenna Steve Horvath Saro H Armenian Frank M Balis Douglas S Hawkins Frank G Keller Melissa M Hudson J Source Type: research
Financial hardship in childhood cancer survivors treated with hematopoietic cell transplant: A report from the Childhood Cancer Survivor Study
CONCLUSIONS: Adult survivors of childhood cancer treated with HCT do not report greater overall financial hardship compared to non-HCT survivors; but greater overall financial hardship compared to sibling controls. Surveillance and intervention may be necessary for all survivors regardless of HCT status.PMID:37541329 | DOI:10.1016/j.jtct.2023.07.024 (Source: Cancer Control)
Source: Cancer Control - August 4, 2023 Category: Cancer & Oncology Authors: David Buchbinder Neel S Bhatt Huiqi Wang Yutaka Yasui Saro Armenian Smita Bhatia Eric J Chow I-Chan Huang Anne C Kirchoff Wendy Leisenring Elyse R Park K Robin Yabroff Gregory T Armstrong Paul C Nathan Nandita Khera Source Type: research
Community coalitions for smoke-free environments in Armenia and Georgia: A mixed methods analysis of coalition formation, implementation and perceived effectiveness
PLoS One. 2023 Aug 3;18(8):e0289149. doi: 10.1371/journal.pone.0289149. eCollection 2023.ABSTRACTEffective models for aligning public health and civil society at the local level have the potential to impact various global health issues, including tobacco. Georgia and Armenia Teams for Healthy Environments and Research (GATHER) is a collaboration between Armenia, Georgia and U.S. researchers involving a community randomized trial testing the impact of community coalitions to promote smoke-free policy adoption and compliance in various settings. Community Coalition Action Theory (CCAT) was used to guide and describe coalitio...
Source: Cancer Control - August 3, 2023 Category: Cancer & Oncology Authors: Michelle C Kegler Ana Dekanosidze Arevik Torosyan Lilit Grigoryan Shaheen Rana Varduhi Hayrumyan Zhanna Sargsyan Carla J Berg Source Type: research
Financial hardship in childhood cancer survivors treated with hematopoietic cell transplant: A report from the Childhood Cancer Survivor Study
Advances in hematopoietic cell transplant (HCT) techniques and supportive care have resulted in an expanding population of HCT survivors.1-2 In the United States (US), it is estimated that there will be more than a half-million long-term survivors of adult and childhood cancers treated with HCT by the year 2030, including approximately 70,000 survivors who underwent HCT at (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - August 1, 2023 Category: Hematology Authors: David Buchbinder, Neel S. Bhatt, Huiqi Wang, Yutaka Yasui, Saro Armenian, Smita Bhatia, Eric J Chow, I-Chan Huang, Anne C Kirchoff, Wendy Leisenring, Elyse R. Park, K. Robin Yabroff, Gregory T. Armstrong, Paul C Nathan, Nandita Khera Source Type: research
Financial Hardship in Childhood Cancer Survivors Treated with Hematopoietic Cell Transplantation: A Report from the Childhood Cancer Survivor Study
Advances in hematopoietic cell transplantation (HCT) techniques and supportive care have resulted in an expanding population of HCT survivors [1,2]. In the United States, it is estimated that by the year 2030, there will be more than 500,000 long-term survivors of adult and childhood cancers treated with HCT, including approximately 70,000 survivors who underwent HCT at age (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - August 1, 2023 Category: Hematology Authors: David Buchbinder, Neel S. Bhatt, Huiqi Wang, Yutaka Yasui, Saro Armenian, Smita Bhatia, Eric J. Chow, I-Chan Huang, Anne C. Kirchoff, Wendy Leisenring, Elyse R. Park, K. Robin Yabroff, Gregory T. Armstrong, Paul C. Nathan, Nandita Khera Tags: Survivorship Source Type: research
Human platelet lysate stimulates neurotrophic properties of human adipose-derived stem cells better than Schwann cell-like cells
CONCLUSIONS: All together, our results show that HPL-ASCs were more neurotrophic than SC-ASCs. We highlighted that the HPL triggers an immature neuro-induction state of ASCs, while keeping their stem properties, paving the way for innovative therapies for nerve regeneration.PMID:37480149 | PMC:PMC10362751 | DOI:10.1186/s13287-023-03407-3 (Source: Cell Research)
Source: Cell Research - July 21, 2023 Category: Cytology Authors: Stefania Brambilla Martino Guiotto Enrica Torretta Ilaria Armenia Matteo Moretti Cecilia Gelfi Silvia Palombella Pietro G di Summa Source Type: research
Results from a phase I trial of pembrolizumab plus vorinostat in relapsed/refractory B-cell non-Hodgkin lymphoma
In conclusion, Pembrolizumab with Vorinostat was tolerable and produced responses in relapsed/refractory B-cell NHL, with particularly notable efficacy in PMBL.PMID:37470137 | DOI:10.3324/haematol.2023.283002 (Source: Haematologica)
Source: Haematologica - July 20, 2023 Category: Hematology Authors: James Godfrey Matthew Mei Lu Chen Joo Y Song Victoria Bedell Elizabeth Budde Saro Armenian Sandrine Puverel Liana Nikolaenko Robert Chen Shari Daniels Neena Kennedy Lacolle Peters Steven T Rosen Stephen J Forman Leslie L Popplewell Larry W Kwak Alex F Her Source Type: research
Results from a phase I trial of pembrolizumab plus vorinostat in relapsed/refractory B-cell non-Hodgkin lymphoma
In conclusion, Pembrolizumab with Vorinostat was tolerable and produced responses in relapsed/refractory B-cell NHL, with particularly notable efficacy in PMBL.PMID:37470137 | DOI:10.3324/haematol.2023.283002 (Source: Haematologica)
Source: Haematologica - July 20, 2023 Category: Hematology Authors: James Godfrey Matthew Mei Lu Chen Joo Y Song Victoria Bedell Elizabeth Budde Saro Armenian Sandrine Puverel Liana Nikolaenko Robert Chen Shari Daniels Neena Kennedy Lacolle Peters Steven T Rosen Stephen J Forman Leslie L Popplewell Larry W Kwak Alex F Her Source Type: research
Results from a phase I trial of pembrolizumab plus vorinostat in relapsed/refractory B-cell non-Hodgkin lymphoma
In conclusion, Pembrolizumab with Vorinostat was tolerable and produced responses in relapsed/refractory B-cell NHL, with particularly notable efficacy in PMBL.PMID:37470137 | DOI:10.3324/haematol.2023.283002 (Source: Haematologica)
Source: Haematologica - July 20, 2023 Category: Hematology Authors: James Godfrey Matthew Mei Lu Chen Joo Y Song Victoria Bedell Elizabeth Budde Saro Armenian Sandrine Puverel Liana Nikolaenko Robert Chen Shari Daniels Neena Kennedy Lacolle Peters Steven T Rosen Stephen J Forman Leslie L Popplewell Larry W Kwak Alex F Her Source Type: research
Results from a phase I trial of pembrolizumab plus vorinostat in relapsed/refractory B-cell non-Hodgkin lymphoma
In conclusion, Pembrolizumab with Vorinostat was tolerable and produced responses in relapsed/refractory B-cell NHL, with particularly notable efficacy in PMBL.PMID:37470137 | DOI:10.3324/haematol.2023.283002 (Source: Haematologica)
Source: Haematologica - July 20, 2023 Category: Hematology Authors: James Godfrey Matthew Mei Lu Chen Joo Y Song Victoria Bedell Elizabeth Budde Saro Armenian Sandrine Puverel Liana Nikolaenko Robert Chen Shari Daniels Neena Kennedy Lacolle Peters Steven T Rosen Stephen J Forman Leslie L Popplewell Larry W Kwak Alex F Her Source Type: research
