Cellulose nanocrystals reinforced chitosan/titanium dioxide bionanocomposite with enhanced interfacial compatibility: Fabrication, characterization, and application in fresh-cut apple slices
Int J Biol Macromol. 2023 Oct 17:127498. doi: 10.1016/j.ijbiomac.2023.127498. Online ahead of print.ABSTRACTThis research aimed to investigate the feasibility of using a bionanocomposite made of chitosan, CNC, and TiO2 nanoparticles to package freshly sliced apples. At the outset, the effect of varying concentrations of CNC (1, 5, and 10 %) and TiO2 (1, 3, and 5 %) on the mechanical, thermal, and water sensitivity characteristics of the chitosan bionanocomposite was studied. Among different combinations, the bionanocomposite containing 10 % CNC and 3 % TiO2 displayed significant enhancements compared to neat chitosan film....
Source: International Journal of Biological Macromolecules - October 20, 2023 Category: Biochemistry Authors: Mohd Ishfaq Bhat Navin Chandra Shahi Umesh Chand Lohani Shivani Pathania Sheeba Malik Shikhangi Singh Tawheed Amin Source Type: research

Daily briefing: COVID drug helps to bring back sense of smell
Nature, Published online: 18 October 2023; doi:10.1038/d41586-023-03273-2An antiviral helps smell and taste return more quickly COVID infection. Plus, how to share data equitably and how lost varieties could unlock better apples. (Source: Nature AOP)
Source: Nature AOP - October 18, 2023 Category: Research Authors: Flora Graham Source Type: research

Apple Polyphenol Extract Ameliorates Atherosclerosis and Associated Cognitive Impairment through Alleviating Neuroinflammation by Weakening TLR4 Signaling and NLRP3 Inflammasome in High-Fat/Cholesterol Diet-Fed LDLR < sup > -/- < /sup > Male Mice
J Agric Food Chem. 2023 Oct 12. doi: 10.1021/acs.jafc.3c01966. Online ahead of print.ABSTRACTAlthough studies have supported the beneficial effects of the ingredients of apple polyphenol extract (APE), a polyphenol mixture being extracted from whole fresh apples, on neurodegenerative diseases, the role of APE in atherosclerosis-related cognitive impairment remains unclear. To clarify the role of APE in regulating cognitive dysfunction in mice with atherosclerosis and the underlying mechanisms, high-fat/cholesterol diet-fed male LDLR-/- mice were gavaged with 125 or 500 mg/(kg·bw·d) APE solution or sterile double-distille...
Source: Atherosclerosis - October 12, 2023 Category: Cardiology Authors: Hao Yang Ruijuan Song Yisha Xie Qingfan Qian Zhengli Wu Shufen Han Xinli Li Source Type: research

Natural product procyanidin B1 as an antitumor drug for effective therapy of colon cancer
Exp Ther Med. 2023 Sep 14;26(5):506. doi: 10.3892/etm.2023.12205. eCollection 2023 Nov.ABSTRACTTraditional chemotherapy drugs have definite antitumor mechanisms and good therapeutic efficacy; however, their poor water solubility, serious side effects and drug resistance limit their clinical application. To the best of our knowledge, the present study reported for the first time the in vivo and in vitro anticancer effects of procyanidin B1 (PCB1), a compound that is isolated from natural sources such as grape seeds, apples, peanut skin and cranberries. Cell Counting Kit-8 assay showed that PCB1 effectively decreased the num...
Source: Experimental and Therapeutic Medicine - October 12, 2023 Category: General Medicine Authors: Yongdong Lei Xiaorong Deng Zhenghong Zhang Jiluan Chen Source Type: research

Apple Polyphenol Extract Ameliorates Atherosclerosis and Associated Cognitive Impairment through Alleviating Neuroinflammation by Weakening TLR4 Signaling and NLRP3 Inflammasome in High-Fat/Cholesterol Diet-Fed LDLR < sup > -/- < /sup > Male Mice
J Agric Food Chem. 2023 Oct 12. doi: 10.1021/acs.jafc.3c01966. Online ahead of print.ABSTRACTAlthough studies have supported the beneficial effects of the ingredients of apple polyphenol extract (APE), a polyphenol mixture being extracted from whole fresh apples, on neurodegenerative diseases, the role of APE in atherosclerosis-related cognitive impairment remains unclear. To clarify the role of APE in regulating cognitive dysfunction in mice with atherosclerosis and the underlying mechanisms, high-fat/cholesterol diet-fed male LDLR-/- mice were gavaged with 125 or 500 mg/(kg·bw·d) APE solution or sterile double-distille...
Source: Atherosclerosis - October 12, 2023 Category: Cardiology Authors: Hao Yang Ruijuan Song Yisha Xie Qingfan Qian Zhengli Wu Shufen Han Xinli Li Source Type: research

Natural product procyanidin B1 as an antitumor drug for effective therapy of colon cancer
Exp Ther Med. 2023 Sep 14;26(5):506. doi: 10.3892/etm.2023.12205. eCollection 2023 Nov.ABSTRACTTraditional chemotherapy drugs have definite antitumor mechanisms and good therapeutic efficacy; however, their poor water solubility, serious side effects and drug resistance limit their clinical application. To the best of our knowledge, the present study reported for the first time the in vivo and in vitro anticancer effects of procyanidin B1 (PCB1), a compound that is isolated from natural sources such as grape seeds, apples, peanut skin and cranberries. Cell Counting Kit-8 assay showed that PCB1 effectively decreased the num...
Source: Experimental and Therapeutic Medicine - October 12, 2023 Category: General Medicine Authors: Yongdong Lei Xiaorong Deng Zhenghong Zhang Jiluan Chen Source Type: research

Bad apples or rotten orchards? Public attitudes of interactions with police and the role of  political ideology
Bad apples or rotten orchards? Public attitudes of interactions with police and the role of political ideology Michael A. Hansen, John C. Navarro Policing: An International Journal, Vol. ahead-of-print, No. ahead-of-print, pp.- The purpose of this study is to explore the ideological gaps across a range of policing interactions with the public.In a survey distributed via Mechanical Turk (MTurk) (n = 979), the authors explore the role that respondents' political ideology plays in the agreement of 13 aspects of policing services, their demeanor and decorum.Attitudes toward policing interactions are slightly positive. Conse...
Source: Policing: An International Journal of Police Strategies and Management - October 12, 2023 Category: Criminology Authors: Michael A. Hansen John C. Navarro Source Type: research

Beyond apples and pears: sex-specific genetics of body fat percentage
ConclusionsThere was limited genetic overlap between BFPAdj in males and females at GWS. BFPAdj loci generally did not have adverse cardiometabolic effects which may reflect the effects of favourable fat distribution and cardiometabolic risk modulation by testosterone and SHBG. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - October 5, 2023 Category: Endocrinology Source Type: research

Commentary: Shaking Trees, Falling Apples
(Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - October 3, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Christopher E. Mascio Source Type: research

Time course of changes in the transcriptome during russet induction in apple fruit
Russeting is a major problem in many fruit crops. Russeting is caused by environmental factors such as wounding or moisture exposure of the fruit surface. Despite extensive research, the molecular sequence tha... (Source: BMC Plant Biology)
Source: BMC Plant Biology - September 30, 2023 Category: Biology Authors: Jannis Straube, Shreya Suvarna, Yun-Hao Chen, Bishnu P. Khanal, Moritz Knoche and Thomas Debener Tags: Research Source Type: research

Smart antimicrobial system based on enzyme-responsive high methoxyl pectin-whey protein isolate nanocomplex for fresh-cut apple preservation
This study introduces a novel intelligent preservation strategy for storing fresh-cut apples.PMID:37748593 | DOI:10.1016/j.ijbiomac.2023.127064 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - September 25, 2023 Category: Biochemistry Authors: Ying Xin Zhenzhen Liu Chenhao Yang Chen Dong Fusheng Chen Kunlun Liu Source Type: research

Smart antimicrobial system based on enzyme-responsive high methoxyl pectin-whey protein isolate nanocomplex for fresh-cut apple preservation
This study introduces a novel intelligent preservation strategy for storing fresh-cut apples.PMID:37748593 | DOI:10.1016/j.ijbiomac.2023.127064 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - September 25, 2023 Category: Biochemistry Authors: Ying Xin Zhenzhen Liu Chenhao Yang Chen Dong Fusheng Chen Kunlun Liu Source Type: research

Label-free Raman microspectroscopic imaging with chemometrics for cellular investigation of apple ring rot and nondestructive early recognition using near-infrared reflection spectroscopy with machine learning
Talanta. 2023 Sep 17;267:125212. doi: 10.1016/j.talanta.2023.125212. Online ahead of print.ABSTRACTApple ring rot caused by Botryosphaeria dothidea can cause fruit decay during the growth and storage stages of apple fruit. Understanding the infection process and cellular defense response at the cellular micro-level holds immense importance in the field of prevention and control. Consequently, there is a pressing need to develop suitable chemical imaging analysis methods. Here we proposed a label-free, high-throughput imaging method for cellular investigation of apple fruit ring rot infected by Botryosphaeria dothidea, base...
Source: Talanta - September 23, 2023 Category: Chemistry Authors: Mei Li Lu Zhang Ling-Li Jiang Zhi-Bo Zhao You-Hua Long Dong-Mei Chen Jun Bin Chao Kang Ya-Juan Liu Source Type: research

Physicians as citizens and the indispensability of civic virtues for professional practice
Incivility poses a serious threat to any healthcare system striving for effectiveness without sacrificing the requirements of humanity. Threats to civility within healthcare not only come from individual ‘bad apples’ exhibiting borderline and inacceptable behaviour, as seen in many ‘high-tech, high-risk, high-responsibility’ environments such as operating or emergency rooms.1 They may also be facilitated by ‘bad trees’ or system-immanent, poor healthcare environments.2 This may be the case when healthcare administrations, facing the challenges of political austerity, set budgetary target...
Source: Journal of Medical Ethics - September 22, 2023 Category: Medical Ethics Authors: Monteverde, S. Tags: Commentary Source Type: research