ASO Author Reflections: Liver-Directed Therapies for Intrahepatic Cholangiocarcinoma: Are We Comparing Apples and Oranges?
Ann Surg Oncol. 2023 Aug 5. doi: 10.1245/s10434-023-14056-4. Online ahead of print.NO ABSTRACTPMID:37543556 | DOI:10.1245/s10434-023-14056-4 (Source: Ann Oncol)
Source: Ann Oncol - August 5, 2023 Category: Cancer & Oncology Authors: Sabran J Masoud Kristen E Rhodin Austin M Eckhoff Michael E Lidsky Source Type: research

ASO Author Reflections: Liver-Directed Therapies for Intrahepatic Cholangiocarcinoma: Are We Comparing Apples and Oranges?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - August 5, 2023 Category: Cancer & Oncology Source Type: research

Bio-based solutions for reducing loss and waste of fresh fruits and vegetables: an industry perspective
Curr Opin Biotechnol. 2023 Aug 2;83:102971. doi: 10.1016/j.copbio.2023.102971. Online ahead of print.ABSTRACTReducing loss and waste of fresh produce requires a systems-wide approach, where supply chain, logistical, and cold chain considerations are balanced with plant breeding, biotechnological, biochemical, and bioinspired solutions. Even though bioengineered specialty crops got off to a rocky start, genetically modified nonbrowning apples and potatoes have been on the market for almost a decade, with bioengineered pineapples, tomatoes, and gene-edited leafy greens with novel taste and nutritional profiles entering the m...
Source: Current Opinion in Biotechnology - August 4, 2023 Category: Biotechnology Authors: Max Teplitski Jeffrey W Touchman Eva Almenar Sarah Evanega Duncan Aust Michelle Yoshinaka Vonnie L Estes Source Type: research

Bio-based solutions for reducing loss and waste of fresh fruits and vegetables: an industry perspective
Curr Opin Biotechnol. 2023 Aug 2;83:102971. doi: 10.1016/j.copbio.2023.102971. Online ahead of print.ABSTRACTReducing loss and waste of fresh produce requires a systems-wide approach, where supply chain, logistical, and cold chain considerations are balanced with plant breeding, biotechnological, biochemical, and bioinspired solutions. Even though bioengineered specialty crops got off to a rocky start, genetically modified nonbrowning apples and potatoes have been on the market for almost a decade, with bioengineered pineapples, tomatoes, and gene-edited leafy greens with novel taste and nutritional profiles entering the m...
Source: Current Opinion in Biotechnology - August 4, 2023 Category: Biotechnology Authors: Max Teplitski Jeffrey W Touchman Eva Almenar Sarah Evanega Duncan Aust Michelle Yoshinaka Vonnie L Estes Source Type: research

Bio-based solutions for reducing loss and waste of fresh fruits and vegetables: an industry perspective
Curr Opin Biotechnol. 2023 Aug 2;83:102971. doi: 10.1016/j.copbio.2023.102971. Online ahead of print.ABSTRACTReducing loss and waste of fresh produce requires a systems-wide approach, where supply chain, logistical, and cold chain considerations are balanced with plant breeding, biotechnological, biochemical, and bioinspired solutions. Even though bioengineered specialty crops got off to a rocky start, genetically modified nonbrowning apples and potatoes have been on the market for almost a decade, with bioengineered pineapples, tomatoes, and gene-edited leafy greens with novel taste and nutritional profiles entering the m...
Source: Current Opinion in Biotechnology - August 4, 2023 Category: Biotechnology Authors: Max Teplitski Jeffrey W Touchman Eva Almenar Sarah Evanega Duncan Aust Michelle Yoshinaka Vonnie L Estes Source Type: research

Bio-based solutions for reducing loss and waste of fresh fruits and vegetables: an industry perspective
Curr Opin Biotechnol. 2023 Aug 2;83:102971. doi: 10.1016/j.copbio.2023.102971. Online ahead of print.ABSTRACTReducing loss and waste of fresh produce requires a systems-wide approach, where supply chain, logistical, and cold chain considerations are balanced with plant breeding, biotechnological, biochemical, and bioinspired solutions. Even though bioengineered specialty crops got off to a rocky start, genetically modified nonbrowning apples and potatoes have been on the market for almost a decade, with bioengineered pineapples, tomatoes, and gene-edited leafy greens with novel taste and nutritional profiles entering the m...
Source: Current Opinion in Biotechnology - August 4, 2023 Category: Biotechnology Authors: Max Teplitski Jeffrey W Touchman Eva Almenar Sarah Evanega Duncan Aust Michelle Yoshinaka Vonnie L Estes Source Type: research

Bio-based solutions for reducing loss and waste of fresh fruits and vegetables: an industry perspective
Curr Opin Biotechnol. 2023 Aug 2;83:102971. doi: 10.1016/j.copbio.2023.102971. Online ahead of print.ABSTRACTReducing loss and waste of fresh produce requires a systems-wide approach, where supply chain, logistical, and cold chain considerations are balanced with plant breeding, biotechnological, biochemical, and bioinspired solutions. Even though bioengineered specialty crops got off to a rocky start, genetically modified nonbrowning apples and potatoes have been on the market for almost a decade, with bioengineered pineapples, tomatoes, and gene-edited leafy greens with novel taste and nutritional profiles entering the m...
Source: Current Opinion in Biotechnology - August 4, 2023 Category: Biotechnology Authors: Max Teplitski Jeffrey W Touchman Eva Almenar Sarah Evanega Duncan Aust Michelle Yoshinaka Vonnie L Estes Source Type: research

Bio-based solutions for reducing loss and waste of fresh fruits and vegetables: an industry perspective
Curr Opin Biotechnol. 2023 Aug 2;83:102971. doi: 10.1016/j.copbio.2023.102971. Online ahead of print.ABSTRACTReducing loss and waste of fresh produce requires a systems-wide approach, where supply chain, logistical, and cold chain considerations are balanced with plant breeding, biotechnological, biochemical, and bioinspired solutions. Even though bioengineered specialty crops got off to a rocky start, genetically modified nonbrowning apples and potatoes have been on the market for almost a decade, with bioengineered pineapples, tomatoes, and gene-edited leafy greens with novel taste and nutritional profiles entering the m...
Source: Current Opinion in Biotechnology - August 4, 2023 Category: Biotechnology Authors: Max Teplitski Jeffrey W Touchman Eva Almenar Sarah Evanega Duncan Aust Michelle Yoshinaka Vonnie L Estes Source Type: research

Viruses, Vol. 15, Pages 1684: Elimination of Solanum nigrum ilarvirus 1 and Apple Hammerhead Viroid from Apple Cultivars Using Antivirals Ribavirin, Rimantadine, and Zidovudine
merák Apple hammerhead viroid (AHVd) was detected in the apple cultivar ‘Šampion’ and in mixed infection with Solanum nigrum ilarvirus 1 (SnIV-1) in the cultivars ‘Selena’ and ‘Jonagored Supra’, using a high-throughput sequencing method. Experiments were conducted to eliminate both pathogens in apples using meristem tip cultures in combination with the antivirotics ribavirin, rimantadine, and zidovudine. Elimination of both pathogens was verified by repeated RT-PCR and qRT-PCR assays after 7–11 months. Elim...
Source: Viruses - August 2, 2023 Category: Virology Authors: Ji ří Sedlák Jaroslava P řibylová Igor Kolo ňuk Josef Špak Ond řej Lenz Mat ěj Semerák Tags: Article Source Type: research

Untargeted metabolomics liquid chromatography ‐high resolution mass spectrometry approach for the geographical origin assessment of Italian dehydrated apples
AbstractGeographical provenience is nowadays a relevant aspect of the authenticity and the quality of many food commodities. Dehydrated apple cubes/slices represent an ingredient commonly used by food companies for bakery products. However, this apple-based matrix is not so known and studied from an analytical point of view. In the present work, seven compounds were identified as key molecules to distinguish between Italian and non-Italian samples, through an untargeted ultrahigh-pressure liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) approach. This methodology was merged with multivariate statistical...
Source: Journal of Mass Spectrometry - August 1, 2023 Category: Chemistry Authors: Giuseppe Sammarco, Chiara Dall'Asta, Michele Suman Tags: RESEARCH ARTICLE Source Type: research

Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RAR α
CONCLUSIONS: Suppression of ASBT by APEVs was indirectly mediated by the downregulation of RARα, and its stability was lowered by microRNAs present in APEVs. This study suggested that macromolecules in food directly affect intestinal function by means of EVs that stabilize them and facilitate their cellular uptake.PMID:37517353 | DOI:10.1016/j.dmpk.2023.100512 (Source: Drug Metabolism and Pharmacokinetics)
Source: Drug Metabolism and Pharmacokinetics - July 30, 2023 Category: Drugs & Pharmacology Authors: Shinya Usui Qiunan Zhu Hisakazu Komori Yui Iwamoto Takumi Nishiuchi Yoshiyuki Shirasaka Ikumi Tamai Source Type: research

Flow-injection MS analysis as a simplified approach to pesticide screening in apples
. (Source: Food Additives and Contaminants Part A)
Source: Food Additives and Contaminants Part A - July 28, 2023 Category: Food Science Authors: Darko Andjelkovic Milica Brankovic Source Type: research

Feasibility and implementation of a grocery shopping intervention for adults diagnosed with or at-risk for type 2 diabetes
CONCLUSIONS: The study had high retention, data were successfully collected remotely, and the intervention was acceptable to most participants. Tailoring recipes to household preferences may be beneficial in future studies.PMID:37496394 | DOI:10.1017/S1368980023001453 (Source: Public Health Nutrition)
Source: Public Health Nutrition - July 27, 2023 Category: International Medicine & Public Health Authors: Kelseanna Hollis-Hansen Sherey Tan Sarah Bargnesi Lily McGovern Julia Drozdowsky Leonard H Epstein Lucia A Leone Eunice Mak Jaclyn Masci Stephanie Anzman-Frasca Source Type: research