Efficacy and safety of prazequantel for the treatment of < i > Schistosoma mansoni < /i > infection across different transmission settings in Amhara Regional State, northwest Ethiopia
ConclusionsA single dose of 40 mg/kg PZQ was efficacious and safe for the treatment ofS.mansoni infection when it was evaluated by the KK test, but a lower efficacy was recorded when it was evaluated by the POC-CCA test. However, the POC-CCA test ’s specificity, clearance time of CCA from urine after treatment, and interpretation of weakly reactive (trace) test results need further research. (Source: PLoS One)
Source: PLoS One - March 4, 2024 Category: Biomedical Science Authors: Getaneh Alemu Source Type: research
Influence of the gut microbiome on appetite-regulating neuropeptides in the hypothalamus: Insight from conventional, antibiotic-treated, and germ-free mouse models of anorexia nervosa
In this study, we investigate the role of the gut microbiome in appetite regulation using activity-based anorexia (ABA) mouse model of anorexia nervosa (AN) - a severe eating disorder with significant health consequences. ABA was induced in conventional, antibiotic-treated, and germ-free mice. Our results show the clear influence of the gut microbiome on the expression of four orexigenic (neuropeptide Y, agouti-related peptide, melanin-concentrating hormone, and orexin) and four anorexigenic peptides (cocaine- and amphetamine-regulated transcript, corticotropin-releasing hormone, thyrotropin-releasing hormone, and pro-opio...
Source: Neurobiology of Disease - March 3, 2024 Category: Neurology Authors: Radka Roubalov á Petra Proch ázková Tereza Kov ářová Janet Je žková Tom áš Hrnčíř Helena Tlaskalov á-Hogenová Hana Pape žová Source Type: research
Cystic fibrosis and fat malabsorption: Pathophysiology of the cystic fibrosis gastrointestinal tract and the impact of highly effective CFTR modulator therapy
Nutr Clin Pract. 2024 Apr;39 Suppl 1:S57-S77. doi: 10.1002/ncp.11122.ABSTRACTCystic fibrosis (CF) is a progressive, genetic, multi-organ disease affecting the respiratory, digestive, endocrine, and reproductive systems. CF can affect any aspect of the gastrointestinal (GI) tract, including the esophagus, stomach, small intestine, colon, pancreas, liver, and gall bladder. GI pathophysiology associated with CF results from CF membrane conductance regulator (CFTR) dysfunction. The majority of people with CF (pwCF) experience exocrine pancreatic insufficiency resulting in malabsorption of nutrients and malnutrition. Additional...
Source: Nutrition in Clinical Practice - March 2, 2024 Category: Nutrition Authors: Catherine M McDonald Elizabeth K Reid John F Pohl Tatiana K Yuzyuk Laura M Padula Kay Vavrina Kimberly Altman Source Type: research
Dissecting the biology of feeding and eating disorders
Trends Mol Med. 2024 Mar 1:S1471-4914(24)00022-4. doi: 10.1016/j.molmed.2024.01.009. Online ahead of print.ABSTRACTFeeding and eating disorders (FEDs) are heterogenous and characterized by varying patterns of dysregulated eating and weight. Genome-wide association studies (GWASs) are clarifying their underlying biology and their genetic relationship to other psychiatric and metabolic/anthropometric traits. Genetic research on anorexia nervosa (AN) has identified eight significant loci and uncovered genetic correlations implicating both psychiatric and metabolic/anthropometric risk factors. Careful explication of these meta...
Source: Trends in Molecular Medicine - March 2, 2024 Category: Molecular Biology Authors: Laura M Huckins Kristen Brennand Cynthia M Bulik Source Type: research
Dissecting the biology of feeding and eating disorders
Trends Mol Med. 2024 Mar 1:S1471-4914(24)00022-4. doi: 10.1016/j.molmed.2024.01.009. Online ahead of print.ABSTRACTFeeding and eating disorders (FEDs) are heterogenous and characterized by varying patterns of dysregulated eating and weight. Genome-wide association studies (GWASs) are clarifying their underlying biology and their genetic relationship to other psychiatric and metabolic/anthropometric traits. Genetic research on anorexia nervosa (AN) has identified eight significant loci and uncovered genetic correlations implicating both psychiatric and metabolic/anthropometric risk factors. Careful explication of these meta...
Source: Molecular Medicine - March 2, 2024 Category: Molecular Biology Authors: Laura M Huckins Kristen Brennand Cynthia M Bulik Source Type: research
Cystic fibrosis and fat malabsorption: Pathophysiology of the cystic fibrosis gastrointestinal tract and the impact of highly effective CFTR modulator therapy
Nutr Clin Pract. 2024 Apr;39 Suppl 1:S57-S77. doi: 10.1002/ncp.11122.ABSTRACTCystic fibrosis (CF) is a progressive, genetic, multi-organ disease affecting the respiratory, digestive, endocrine, and reproductive systems. CF can affect any aspect of the gastrointestinal (GI) tract, including the esophagus, stomach, small intestine, colon, pancreas, liver, and gall bladder. GI pathophysiology associated with CF results from CF membrane conductance regulator (CFTR) dysfunction. The majority of people with CF (pwCF) experience exocrine pancreatic insufficiency resulting in malabsorption of nutrients and malnutrition. Additional...
Source: Nutrition in Clinical Practice - March 2, 2024 Category: Nutrition Authors: Catherine M McDonald Elizabeth K Reid John F Pohl Tatiana K Yuzyuk Laura M Padula Kay Vavrina Kimberly Altman Source Type: research
Dissecting the biology of feeding and eating disorders
Trends Mol Med. 2024 Mar 1:S1471-4914(24)00022-4. doi: 10.1016/j.molmed.2024.01.009. Online ahead of print.ABSTRACTFeeding and eating disorders (FEDs) are heterogenous and characterized by varying patterns of dysregulated eating and weight. Genome-wide association studies (GWASs) are clarifying their underlying biology and their genetic relationship to other psychiatric and metabolic/anthropometric traits. Genetic research on anorexia nervosa (AN) has identified eight significant loci and uncovered genetic correlations implicating both psychiatric and metabolic/anthropometric risk factors. Careful explication of these meta...
Source: Trends in Molecular Medicine - March 2, 2024 Category: Molecular Biology Authors: Laura M Huckins Kristen Brennand Cynthia M Bulik Source Type: research
Cystic fibrosis and fat malabsorption: Pathophysiology of the cystic fibrosis gastrointestinal tract and the impact of highly effective CFTR modulator therapy
Nutr Clin Pract. 2024 Apr;39 Suppl 1:S57-S77. doi: 10.1002/ncp.11122.ABSTRACTCystic fibrosis (CF) is a progressive, genetic, multi-organ disease affecting the respiratory, digestive, endocrine, and reproductive systems. CF can affect any aspect of the gastrointestinal (GI) tract, including the esophagus, stomach, small intestine, colon, pancreas, liver, and gall bladder. GI pathophysiology associated with CF results from CF membrane conductance regulator (CFTR) dysfunction. The majority of people with CF (pwCF) experience exocrine pancreatic insufficiency resulting in malabsorption of nutrients and malnutrition. Additional...
Source: Nutrition in Clinical Practice - March 2, 2024 Category: Nutrition Authors: Catherine M McDonald Elizabeth K Reid John F Pohl Tatiana K Yuzyuk Laura M Padula Kay Vavrina Kimberly Altman Source Type: research
Dissecting the biology of feeding and eating disorders
Trends Mol Med. 2024 Mar 1:S1471-4914(24)00022-4. doi: 10.1016/j.molmed.2024.01.009. Online ahead of print.ABSTRACTFeeding and eating disorders (FEDs) are heterogenous and characterized by varying patterns of dysregulated eating and weight. Genome-wide association studies (GWASs) are clarifying their underlying biology and their genetic relationship to other psychiatric and metabolic/anthropometric traits. Genetic research on anorexia nervosa (AN) has identified eight significant loci and uncovered genetic correlations implicating both psychiatric and metabolic/anthropometric risk factors. Careful explication of these meta...
Source: Trends in Molecular Medicine - March 2, 2024 Category: Molecular Biology Authors: Laura M Huckins Kristen Brennand Cynthia M Bulik Source Type: research
Health-related quality of life, psychological issues and concerns among sarcoma survivors: a mixed method study
CONCLUSION: A substantial number of sarcoma survivors had an average HRQoL and experienced depression, anxiety and stress. Our study emphasizes the importance of holistic survivorship care, involving nurses in post-treatment support, and addressing societal discrimination and psychosocial concerns to enhance their quality of life.IMPLICATIONS FOR CANCER SURVIVORS: Our study calls for a holistic approach to sarcoma survivor care and emphasizes the importance of personalised survivorship care plans led by nurses to address the diverse needs of sarcoma survivors in India. Such plans should encompass strategies for managing de...
Source: Ecancermedicalscience - March 1, 2024 Category: Cancer & Oncology Authors: Arti Suhag Kamlesh Kumari Sharma Surya Kant Tiwari Poonam Joshi Sameer Rastogi Simran Kaur Source Type: research
