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Antimicrobial resistance profiles of Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae strains isolated from broiler chickens
Food Microbiol. 2024 Jun;120:104476. doi: 10.1016/j.fm.2024.104476. Epub 2024 Jan 10.ABSTRACTGlobally, the spread of multidrug-resistant Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae from food to humans poses a severe threat to public health. The aim of this study was to assess the co-occurrence of colistin and β-lactamase resistance genes in E. coli, K. pneumoniae, and P. aeruginosa strains isolated from faeces of abattoir broiler chickens. The E. coli, P. aeruginosa and K. pneumoniae isolates were successfully detected from faecal samples by polymerase chain reaction (PCR) at infection rates of 60....
Source: Food Microbiology - March 2, 2024 Category: Food Science Authors: Tsepo Ramatla Prudent Mokgokong Kgaugelo Lekota Oriel Thekisoe Source Type: research

Synthesis and characterization of nanocomposite based polymeric membrane (PES/PVP/GO-TiO 2 ) and performance evaluation for the removal of various antibiotics (amoxicillin, azithromycin & amp; ciprofloxacin) from aqueous solution
This study presents an innovative approach through the fabrication and evaluation of a Polyethersulfone (PES) membrane adorned with GO-TiO2 nanocomposites. The objective is to enhance the removal efficiency of various antibiotics, addressing the challenge of emerging organic compounds (EOCs) in water systems. The nanocomposite membranes, synthesized via the phase inversion method, incorporate hydrophilic agents, specifically GO-TiO2 nanocomposites and Polyvinylpyrrolidone (PVP). The resultant membranes underwent comprehensive characterization employing AFM, EDS, tensile strength testing, water contact angle measurements, a...
Source: Chemosphere - March 1, 2024 Category: Chemistry Authors: Rohit Goyat Joginder Singh Ahmad Umar Yajvinder Saharan Ahmed A Ibrahim Sheikh Akbar Sotirios Baskoutas Source Type: research

Invasive disease caused simultaneously by two different serotypes of Streptococcus pneumoniae: a microbiological appreciation
We report a clinical case of a child with an invasive pneumococcal disease caused by two different pneumococcal serotypes that belonged to different sequence types. She was a 15-month-old girl with pneumonia and pleural effusion in whichS. pneumoniae colonies with different morphologies grew, one from the blood culture (characteristic greyish appearance) and the other from the pleural fluid (mucoid appearance). The isolate from blood was serotype 22 F (ST698/CC698/GPSC61), while the isolate from the pleural fluid was serotype 3 (ST180/CC180/GPSC12). The patient fully recovered after treatment with intravenous ampicillin ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 28, 2024 Category: Microbiology Source Type: research

Effects of Preoperative Quadruple Therapy for Helicobacter pylori on Bariatric Surgery Metabolic Outcomes
ConclusionsPreoperative treatment with OCAM has been associated to poorer glycemic and weight loss outcomes after BS. More research is needed on the influence of OCAM on gut microbiota, and in turn, the effect of the latter on metabolic and weight loss outcomes after BS.Graphical Abstract (Source: Obesity Surgery)
Source: Obesity Surgery - February 24, 2024 Category: Surgery Source Type: research

Vonoprazan: A Review in Helicobacter pylori Infection
AbstractTreatment for the eradication ofHelicobacter pylori infection, a leading cause of peptic ulcer disease and an important risk factor for gastric cancer and mucosa-associated lymphoid tissue lymphoma, is indicated whenever infection is identified. However, treatment success rates with current guideline-recommended proton-pump inhibitor (PPI)-based regimens remain suboptimal, with one potential factor associated with treatment failure being inadequate acid suppression. Vonoprazan (Voquezna®) is a first-in-class potassium-competitive acid blocker with the potential to provide potent and sustained acid suppression. Fol...
Source: Drugs - February 23, 2024 Category: Drugs & Pharmacology Source Type: research

Phenotypic and Genotypic Characterization of Extended Spectrum Beta-Lactamase-Producing Clinical Isolates of Escherichia coli and Klebsiella pneumoniae in Two Kenyan Facilities: A National Referral and a Level Five Hospital
CONCLUSIONS: The high proportion of ESBL-producing E. coli and K. pneumoniae isolates increases the utilization of last-resort antibiotics, jeopardizing antimicrobial chemotherapy. Furthermore, the antimicrobial resistance patterns exhibited towards extended-spectrum cephalosporins, beta-lactam/beta-lactamase inhibitor combinations, fluoroquinolones, and macrolides show the risk of co-resistance associated with ESBL-producing isolates responsible for MDR. Hence, there is a need for regular surveillance and implementation of infection prevention and control strategies and antimicrobial stewardship programs.PMID:38384586 | P...
Source: International Journal of Microbiology - February 22, 2024 Category: Microbiology Authors: Sylvia M Maveke Gabriel O Aboge Laetitia W Kanja Alfred O Mainga Naftaly Gachau Beatrice W Muchira Gervason A Moriasi Source Type: research

Case reports involving coinfection with Avibacterium paragallinarum and Ornithobacterium rhinotracheale in broiler chickens and Avibacterium endocarditis in broiler breeding hens in Poland
Avian Pathol. 2024 Feb 22:1-33. doi: 10.1080/03079457.2024.2323029. Online ahead of print.ABSTRACTAbstractThe study describes three clinical cases of infection with Avibacterium spp.. In case no. 1, respiratory clinical signs and high mortality (0.7-4.2% daily; total 21.2%) in broiler chickens Ross 308 were shown to be caused by coinfection with sequence type 9 of O. rhinotracheale presumptive serotype A and A. paragallinarum presumptive serotype B. The identical PFGE restriction pattern (pulsotype) of seven A. paragallinarum isolates indicated that infectious coryza (IC) in broilers was caused by the same clone. In cases ...
Source: Avian Pathology - February 22, 2024 Category: Pathology Authors: Dagmara St ępień-Pyśniak Marta Dec Tomasz Hauschild Olimpia Kursa Agnieszka Marek Jaros ław Wilczyński Micha ł Brzeski Source Type: research

Anaerobic antibiotic coverage in aspiration pneumonia and the associated benefits and harms: A retrospective cohort study
Chest. 2024 Feb 20:S0012-3692(24)00260-5. doi: 10.1016/j.chest.2024.02.025. Online ahead of print.ABSTRACTBACKGROUND: Antibiotics with extended anaerobic coverage are commonly used to treat aspiration pneumonia, which is not recommended by current guidelines.RESEARCH QUESTION: In patients admitted to hospital for community-acquired aspiration pneumonia, is there a difference between antibiotic therapy with limited anaerobic coverage (LAC) versus antibiotic therapy with extended anaerobic coverage (EAC) in terms of in-hospital mortality and risk of Clostridioides difficile colitis?METHODS: We conducted a multicenter retrosp...
Source: Chest - February 22, 2024 Category: Respiratory Medicine Authors: Anthony D Bai Siddhartha Srivastava Genevi ève C Digby Vincent Girard Fahad Razak Amol A Verma Source Type: research

Biotic pathways of reciprocal responses between antibiotic resistance genes and inorganic nitrogen cycling genes in amoxicillin-stressed compost ecosystems
This study explored the transformation of inorganic nitrogen, the expression levels of antibiotic resistance genes (ARGs), and the regulatory mechanisms of key species on ARGs and inorganic nitrogen cycling genes (INCGs) under different levels of amoxicillin (AMX) stress. High level of AMX inhibited the accumulation of NH4+-N, which increased by 531 % relative to the initial. Moreover, AMX to some extent increased the levels of nirS and nirK, which could potentially result in nitrogen loss and the accumulation of NO2-. Actinobacteria might serve as potential hosts for ARGs during sludge composting. This stress induced a co...
Source: Bioresource Technology - February 22, 2024 Category: Biotechnology Authors: Xinlin Zhang Ziyi Han Yumeng Wang Kunxue Cui Yu Li Xinyu Xie Xu Zhang Source Type: research