No evidence of difference in mortality with amoxicillin versus co-amoxiclav for hospital treatment of community-acquired pneumonia
Current guidelines recommend broad-spectrum antibiotics for high-severity community-acquired pneumonia (CAP), potentially contributing to antimicrobial resistance (AMR). We aim to compare outcomes in CAP patients treated with amoxicillin (narrow-spectrum) versus co-amoxiclav (broad-spectrum), to understand if narrow-spectrum antibiotics could be used more widely. (Source: Journal of Infection)
Source: Journal of Infection - April 23, 2024 Category: Infectious Diseases Authors: Jia Wei, Aashna Uppal, Christy Nganjimi, Hermione Warr, Yasin Ibrahim, Qingze Gu, Hang Yuan, Najib M Rahman, Nicola Jones, A Sarah Walker, David W Eyre Source Type: research
Streptococcal Pharyngitis: Rapid Evidence Review
Am Fam Physician. 2024 Apr;109(4):343-349.ABSTRACTGroup A beta-hemolytic streptococcal pharyngitis is a common infection responsible for more than 6 million office visits in the United States annually. Only 10% of adults seeking care for a sore throat have group A beta-hemolytic streptococcal pharyngitis; however, 60% or more are prescribed antibiotics. Guidelines recommend using clinical decision rules to assess the risk of group A beta-hemolytic streptococcal infection, followed by rapid antigen testing if a diagnosis is unclear, before prescribing antibiotics. Fever, tonsillar exudate, cervical lymphadenitis, and patien...
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Jennifer L Hamilton Leon McCrea Ii Source Type: research
Streptococcal Pharyngitis: Rapid Evidence Review
Am Fam Physician. 2024 Apr;109(4):343-349.ABSTRACTGroup A beta-hemolytic streptococcal pharyngitis is a common infection responsible for more than 6 million office visits in the United States annually. Only 10% of adults seeking care for a sore throat have group A beta-hemolytic streptococcal pharyngitis; however, 60% or more are prescribed antibiotics. Guidelines recommend using clinical decision rules to assess the risk of group A beta-hemolytic streptococcal infection, followed by rapid antigen testing if a diagnosis is unclear, before prescribing antibiotics. Fever, tonsillar exudate, cervical lymphadenitis, and patien...
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Jennifer L Hamilton Leon McCrea Ii Source Type: research
Streptococcal Pharyngitis: Rapid Evidence Review
Am Fam Physician. 2024 Apr;109(4):343-349.ABSTRACTGroup A beta-hemolytic streptococcal pharyngitis is a common infection responsible for more than 6 million office visits in the United States annually. Only 10% of adults seeking care for a sore throat have group A beta-hemolytic streptococcal pharyngitis; however, 60% or more are prescribed antibiotics. Guidelines recommend using clinical decision rules to assess the risk of group A beta-hemolytic streptococcal infection, followed by rapid antigen testing if a diagnosis is unclear, before prescribing antibiotics. Fever, tonsillar exudate, cervical lymphadenitis, and patien...
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Jennifer L Hamilton Leon McCrea Ii Source Type: research
Streptococcal Pharyngitis: Rapid Evidence Review
Am Fam Physician. 2024 Apr;109(4):343-349.ABSTRACTGroup A beta-hemolytic streptococcal pharyngitis is a common infection responsible for more than 6 million office visits in the United States annually. Only 10% of adults seeking care for a sore throat have group A beta-hemolytic streptococcal pharyngitis; however, 60% or more are prescribed antibiotics. Guidelines recommend using clinical decision rules to assess the risk of group A beta-hemolytic streptococcal infection, followed by rapid antigen testing if a diagnosis is unclear, before prescribing antibiotics. Fever, tonsillar exudate, cervical lymphadenitis, and patien...
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Jennifer L Hamilton Leon McCrea Ii Source Type: research
Streptococcal Pharyngitis: Rapid Evidence Review
Am Fam Physician. 2024 Apr;109(4):343-349.ABSTRACTGroup A beta-hemolytic streptococcal pharyngitis is a common infection responsible for more than 6 million office visits in the United States annually. Only 10% of adults seeking care for a sore throat have group A beta-hemolytic streptococcal pharyngitis; however, 60% or more are prescribed antibiotics. Guidelines recommend using clinical decision rules to assess the risk of group A beta-hemolytic streptococcal infection, followed by rapid antigen testing if a diagnosis is unclear, before prescribing antibiotics. Fever, tonsillar exudate, cervical lymphadenitis, and patien...
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Jennifer L Hamilton Leon McCrea Ii Source Type: research
Liquid chromatography with tandem mass spectrometric method for determination of 52 antibiotics in human whole blood and urine and application to forensic cases
ConclusionsA simple, sensitive and high-throughput method for the simultaneous determination of different classes of antibiotics in urine and whole blood samples was developed and applied. This sensitive method was successfully applied to forensic cases. (Source: Forensic Toxicology)
Source: Forensic Toxicology - April 20, 2024 Category: Forensic Medicine Source Type: research
Dynamics of microbiota and antimicrobial resistance in on-farm dairy processing plants using metagenomic and culture-dependent approaches
Int J Food Microbiol. 2024 Apr 14;417:110704. doi: 10.1016/j.ijfoodmicro.2024.110704. Online ahead of print.ABSTRACTOn-farm dairy processing plants, which are situated close to farms and larger dairy processing facilities, face unique challenges in maintaining environmental hygiene. This can impact various stages of dairy processing. These plants operate on smaller scales and use Low-Temperature-Long-Time (LTLT) pasteurization, making them more susceptible to microbial contamination through direct and indirect contact. Antimicrobial-resistant bacteria found on dairy farms pose risks to human health by potentially transferr...
Source: International Journal of Food Microbiology - April 19, 2024 Category: Food Science Authors: Saehah Yi Hyokeun Song Woo-Hyun Kim Soomin Lee Jae-Ho Guk JungHa Woo Seongbeom Cho Source Type: research
The vehicle of administration, feed or water, and prandial state influence the oral bioavailability of amoxicillin in piglets
AbstractFeed and water components may interact with drugs and affect their dissolution and bioavailability. The impact of the vehicle of administration (feed and water) and the prandial condition of weaner piglets on amoxicillin ´s oral bioavailability was evaluated. First, amoxicillin’s in vitro dissolution and stability in purified, soft, and hard water, as well as release kinetics from feed in simulated gastric and intestinal media were assessed. Then, pharmacokinetic parameters and bioavailability were determined in fasted and fed pigs using soft water, hard water, or feed as vehicles of administration following a b...
Source: Veterinary Research Communications - April 17, 2024 Category: Veterinary Research Source Type: research
Antibiotics Not Associated with Shorter Duration or Reduced Severity of Acute Lower Respiratory Tract Infection
ConclusionsIn this large prospective study in the US primary and urgent care setting, antibiotics had no measurable impact on the severity or duration of cough due to acute LRTI. Patients had unrealistic expectations regarding the duration of LRTI and the effect of antibiotics which should be the target of antibiotic stewardship efforts. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - April 15, 2024 Category: Internal Medicine Source Type: research
Antibiotic prescribing patterns in the placement of dental implants in Europe: A systematic review of survey-based studies
CONCLUSIONS: The most commonly prescribed antibiotic both pre- and postoperatively is amoxicillin and, in allergic patients, clindamycin. In Europe, more doses of PAT are being prescribed than suggested by current recommendations. For this reason, more PAT education is needed in educational curricula to promote a more rational use of antibiotics to reduce the occurrence of antimicrobial resistance.PMID:38615255 | DOI:10.4317/medoral.26450 (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - April 14, 2024 Category: ENT & OMF Authors: Á-O Salgado-Peralvo N Kewalramani A P érez-Jardón M P érez-Sayáns M-V Mateos-Moreno L Arriba-Fuente Source Type: research
