Effects of Serum Antibody Test Reagent Discontinuation on Diagnosis of Amebiasis in Japan: Interrupted Time-Series Analysis
This study aimed to investigate changes occurring after discontinuation of the serum antibody test reagent production. We retrospectively analyzed amebiasis cases from January 2014 to December 2019 using the National Center for Epidemiology of Infectious Diseases system. Interrupted time-series regression analysis was used to evaluate trends in weekly amebiasis cases before and after the discontinuation period. The study period was divided into prediscontinuation (2014-2017) and discontinuation (2018-2019) periods. A total of 6,179 amebiasis cases were reported. The average numbers of weekly cases were 21.5 during 2014-201...
Source: Am J Trop Med Hyg - December 11, 2023 Category: Infectious Diseases Authors: Yoshiro Hadano Hirotake Mori Satoshi Oono Source Type: research
Effects of Serum Antibody Test Reagent Discontinuation on Diagnosis of Amebiasis in Japan: Interrupted Time-Series Analysis
This study aimed to investigate changes occurring after discontinuation of the serum antibody test reagent production. We retrospectively analyzed amebiasis cases from January 2014 to December 2019 using the National Center for Epidemiology of Infectious Diseases system. Interrupted time-series regression analysis was used to evaluate trends in weekly amebiasis cases before and after the discontinuation period. The study period was divided into prediscontinuation (2014-2017) and discontinuation (2018-2019) periods. A total of 6,179 amebiasis cases were reported. The average numbers of weekly cases were 21.5 during 2014-201...
Source: Am J Trop Med Hyg - December 11, 2023 Category: Infectious Diseases Authors: Yoshiro Hadano Hirotake Mori Satoshi Oono Source Type: research
Effects of Serum Antibody Test Reagent Discontinuation on Diagnosis of Amebiasis in Japan: Interrupted Time-Series Analysis
This study aimed to investigate changes occurring after discontinuation of the serum antibody test reagent production. We retrospectively analyzed amebiasis cases from January 2014 to December 2019 using the National Center for Epidemiology of Infectious Diseases system. Interrupted time-series regression analysis was used to evaluate trends in weekly amebiasis cases before and after the discontinuation period. The study period was divided into prediscontinuation (2014-2017) and discontinuation (2018-2019) periods. A total of 6,179 amebiasis cases were reported. The average numbers of weekly cases were 21.5 during 2014-201...
Source: The American Journal of Tropical Medicine and Hygiene - December 11, 2023 Category: Tropical Medicine Authors: Yoshiro Hadano Hirotake Mori Satoshi Oono Source Type: research
Effects of Serum Antibody Test Reagent Discontinuation on Diagnosis of Amebiasis in Japan: Interrupted Time-Series Analysis
This study aimed to investigate changes occurring after discontinuation of the serum antibody test reagent production. We retrospectively analyzed amebiasis cases from January 2014 to December 2019 using the National Center for Epidemiology of Infectious Diseases system. Interrupted time-series regression analysis was used to evaluate trends in weekly amebiasis cases before and after the discontinuation period. The study period was divided into prediscontinuation (2014-2017) and discontinuation (2018-2019) periods. A total of 6,179 amebiasis cases were reported. The average numbers of weekly cases were 21.5 during 2014-201...
Source: Am J Trop Med Hyg - December 11, 2023 Category: Infectious Diseases Authors: Yoshiro Hadano Hirotake Mori Satoshi Oono Source Type: research
Effects of Serum Antibody Test Reagent Discontinuation on Diagnosis of Amebiasis in Japan: Interrupted Time-Series Analysis
This study aimed to investigate changes occurring after discontinuation of the serum antibody test reagent production. We retrospectively analyzed amebiasis cases from January 2014 to December 2019 using the National Center for Epidemiology of Infectious Diseases system. Interrupted time-series regression analysis was used to evaluate trends in weekly amebiasis cases before and after the discontinuation period. The study period was divided into prediscontinuation (2014-2017) and discontinuation (2018-2019) periods. A total of 6,179 amebiasis cases were reported. The average numbers of weekly cases were 21.5 during 2014-201...
Source: The American Journal of Tropical Medicine and Hygiene - December 11, 2023 Category: Tropical Medicine Authors: Yoshiro Hadano Hirotake Mori Satoshi Oono Source Type: research
Effects of Serum Antibody Test Reagent Discontinuation on Diagnosis of Amebiasis in Japan: Interrupted Time-Series Analysis
This study aimed to investigate changes occurring after discontinuation of the serum antibody test reagent production. We retrospectively analyzed amebiasis cases from January 2014 to December 2019 using the National Center for Epidemiology of Infectious Diseases system. Interrupted time-series regression analysis was used to evaluate trends in weekly amebiasis cases before and after the discontinuation period. The study period was divided into prediscontinuation (2014-2017) and discontinuation (2018-2019) periods. A total of 6,179 amebiasis cases were reported. The average numbers of weekly cases were 21.5 during 2014-201...
Source: Am J Trop Med Hyg - December 11, 2023 Category: Infectious Diseases Authors: Yoshiro Hadano Hirotake Mori Satoshi Oono Source Type: research
Effects of Serum Antibody Test Reagent Discontinuation on Diagnosis of Amebiasis in Japan: Interrupted Time-Series Analysis
This study aimed to investigate changes occurring after discontinuation of the serum antibody test reagent production. We retrospectively analyzed amebiasis cases from January 2014 to December 2019 using the National Center for Epidemiology of Infectious Diseases system. Interrupted time-series regression analysis was used to evaluate trends in weekly amebiasis cases before and after the discontinuation period. The study period was divided into prediscontinuation (2014-2017) and discontinuation (2018-2019) periods. A total of 6,179 amebiasis cases were reported. The average numbers of weekly cases were 21.5 during 2014-201...
Source: The American Journal of Tropical Medicine and Hygiene - December 11, 2023 Category: Tropical Medicine Authors: Yoshiro Hadano Hirotake Mori Satoshi Oono Source Type: research
Effects of Serum Antibody Test Reagent Discontinuation on Diagnosis of Amebiasis in Japan: Interrupted Time-Series Analysis
This study aimed to investigate changes occurring after discontinuation of the serum antibody test reagent production. We retrospectively analyzed amebiasis cases from January 2014 to December 2019 using the National Center for Epidemiology of Infectious Diseases system. Interrupted time-series regression analysis was used to evaluate trends in weekly amebiasis cases before and after the discontinuation period. The study period was divided into prediscontinuation (2014-2017) and discontinuation (2018-2019) periods. A total of 6,179 amebiasis cases were reported. The average numbers of weekly cases were 21.5 during 2014-201...
Source: Am J Trop Med Hyg - December 11, 2023 Category: Infectious Diseases Authors: Yoshiro Hadano Hirotake Mori Satoshi Oono Source Type: research
Effects of Serum Antibody Test Reagent Discontinuation on Diagnosis of Amebiasis in Japan: Interrupted Time-Series Analysis
This study aimed to investigate changes occurring after discontinuation of the serum antibody test reagent production. We retrospectively analyzed amebiasis cases from January 2014 to December 2019 using the National Center for Epidemiology of Infectious Diseases system. Interrupted time-series regression analysis was used to evaluate trends in weekly amebiasis cases before and after the discontinuation period. The study period was divided into prediscontinuation (2014-2017) and discontinuation (2018-2019) periods. A total of 6,179 amebiasis cases were reported. The average numbers of weekly cases were 21.5 during 2014-201...
Source: The American Journal of Tropical Medicine and Hygiene - December 11, 2023 Category: Tropical Medicine Authors: Yoshiro Hadano Hirotake Mori Satoshi Oono Source Type: research
Antigiardial and antiamebic activities of fexinidazole and its metabolites: new drug leads for giardiasis and amebiasis
Antimicrob Agents Chemother. 2023 Dec 8:e0073123. doi: 10.1128/aac.00731-23. Online ahead of print.ABSTRACTThe intestinal parasites Giardia lamblia and Entamoeba histolytica are major causes of morbidity and mortality associated with diarrheal diseases. Metronidazole is the most common drug used to treat giardiasis and amebiasis. Despite its efficacy, treatment failures in giardiasis occur in up to 5%-40% of cases. Potential resistance of E. histolytica to metronidazole is an increasing concern. Therefore, it is critical to search for more effective drugs to treat giardiasis and amebiasis. We identified antigiardial and an...
Source: Antimicrobial Agents and Chemotherapy - December 8, 2023 Category: Microbiology Authors: Jose Ignacio Escrig Yukiko Miyamoto Alejandro Delgado Aznar Lars Eckmann Anjan Debnath Source Type: research
Antigiardial and antiamebic activities of fexinidazole and its metabolites: new drug leads for giardiasis and amebiasis
Antimicrob Agents Chemother. 2023 Dec 8:e0073123. doi: 10.1128/aac.00731-23. Online ahead of print.ABSTRACTThe intestinal parasites Giardia lamblia and Entamoeba histolytica are major causes of morbidity and mortality associated with diarrheal diseases. Metronidazole is the most common drug used to treat giardiasis and amebiasis. Despite its efficacy, treatment failures in giardiasis occur in up to 5%-40% of cases. Potential resistance of E. histolytica to metronidazole is an increasing concern. Therefore, it is critical to search for more effective drugs to treat giardiasis and amebiasis. We identified antigiardial and an...
Source: Antimicrobial Agents and Chemotherapy - December 8, 2023 Category: Microbiology Authors: Jose Ignacio Escrig Yukiko Miyamoto Alejandro Delgado Aznar Lars Eckmann Anjan Debnath Source Type: research
Antigiardial and antiamebic activities of fexinidazole and its metabolites: new drug leads for giardiasis and amebiasis
Antimicrob Agents Chemother. 2023 Dec 8:e0073123. doi: 10.1128/aac.00731-23. Online ahead of print.ABSTRACTThe intestinal parasites Giardia lamblia and Entamoeba histolytica are major causes of morbidity and mortality associated with diarrheal diseases. Metronidazole is the most common drug used to treat giardiasis and amebiasis. Despite its efficacy, treatment failures in giardiasis occur in up to 5%-40% of cases. Potential resistance of E. histolytica to metronidazole is an increasing concern. Therefore, it is critical to search for more effective drugs to treat giardiasis and amebiasis. We identified antigiardial and an...
Source: Antimicrobial Agents and Chemotherapy - December 8, 2023 Category: Microbiology Authors: Jose Ignacio Escrig Yukiko Miyamoto Alejandro Delgado Aznar Lars Eckmann Anjan Debnath Source Type: research
The Challenging Path to Diagnosing Extraintestinal Amoebiasis: A Case Report of an HIV-Infected Patient
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - December 8, 2023 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Advances in the Development of Carbonic Anhydrase Inhibitors as New Antiprotozoal Agents
CONCLUSION: According to this review, advances in discovering compounds with potent inhibitory activity suggest that CA is a candidate for developing new antiprotozoal agents.PMID:37909441 | DOI:10.2174/0109298673249553231018070920 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - November 1, 2023 Category: Chemistry Authors: Eyra Ortiz-Perez Lenci K Vazquez-Jimenez Alma D Paz-Gonzalez Timoteo Delgado-Maldonado Alonzo Gonz ález González Carlos Gaona-Lopez Antonio Moreno-Herrera Karina Vazquez Gildardo Rivera Source Type: research
A systematic review of neglected tropical diseases (NTDs) in Myanmar
ConclusionThis review summarises NTDs reported in Myanmar over the past 100 years. The findings suggest that most NTDs are likely to be under reported, especially from the majority of the country which is far from academic centres. Research capacity building together with strengthening of laboratory systems would lead to better understanding of the true burden of NTDs in Myanmar. Trial registrationPROSPERO registration ID: CRD42018092627. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - November 1, 2023 Category: Tropical Medicine Authors: Myo Maung Maung Swe Source Type: research
