Efficacy of Allopurinol in Improving Endothelial Dysfunction: A Systematic Review and Meta-Analysis
ConclusionWhile allopurinol may improve endothelial function in various patient populations, further high-quality randomized controlled trials are needed to determine its efficacy in preventing cardiovascular disease exacerbation. (Source: High Blood Pressure and Cardiovascular Prevention)
Source: High Blood Pressure and Cardiovascular Prevention - December 9, 2023 Category: Cardiology Source Type: research
Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries
Arch Toxicol. 2023 Dec 5. doi: 10.1007/s00204-023-03630-0. Online ahead of print.ABSTRACTIdiosyncratic drug-induced liver injury (DILI) associated with drug reactions with eosinophilia and systemic symptoms (DRESS) is poorly characterized among patients of Western countries. We aimed to comprehensively assess the clinical characteristics, outcomes, and causative agents in a prospective, well-vetted cohort of DILI patients with DRESS (DILI-DRESS). We identified 53 DILI-DRESS cases from the Spanish DILI Registry and the Latin American DILI Network. For comparison purposes, we defined a group of DILI patients (n = 881). DILI-...
Source: Archives of Toxicology - December 5, 2023 Category: Toxicology Authors: Inmaculada Medina-C áliz Judith Sanabria-Cabrera Marina Villanueva-Paz Lauryna Auk štikalnė Camilla Stephens Mercedes Robles-D íaz Jos é M Pinazo-Bandera Miren Garc ía-Cortes Isabel Conde German Soriano Fernando Bessone Nelia Hernandez Vinicius Nune Source Type: research
GSE189228 Establishment of a 3D hyperuricemia model based on cultured human liver organoids
Contributors : Maojin Yao ; Jiaoyan Ren ; Chuanli Hou ; Yang HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHyperuricemia (HUA) is a metabolic disease caused by abnormal purine metabolism, the prevalence of which has increased worldwide. Here, a 3D organoid culture system for mimicking HUA in vitro was established using cultured human liver organoids. Liver organoids can be generated from single hepatocytes and passaged for several months, retaining key morphological features, functional purine metabolism and global gene expression profile. Furthermore, organoids can be differe...
Source: GEO: Gene Expression Omnibus - December 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Celebrating Versatility: Febuxostat's Multifaceted Therapeutic Application
Life (Basel). 2023 Nov 11;13(11):2199. doi: 10.3390/life13112199.ABSTRACTFebuxostat, initially developed as a xanthine oxidase inhibitor to address hyperuricemia in gout patients, has evolved into a versatile therapeutic agent with multifaceted applications. This review provides a comprehensive overview of febuxostat's mechanism of action, its effectiveness in gout management, its cardiovascular safety profile, renal and hepatic effects, musculoskeletal applications, safety considerations, and emerging research prospects. Febuxostat's primary mechanism involves selective inhibition of xanthine oxidase, resulting in reduced...
Source: Cancer Control - November 25, 2023 Category: Cancer & Oncology Authors: Krasimir Iliev Kraev Mariela Gencheva Geneva-Popova Bozhidar Krasimirov Hristov Petar Angelov Uchikov Stanislava Dimitrova Popova-Belova Maria Ilieva Kraeva Yordanka Mincheva Basheva-Kraeva Nina Staneva Stoyanova Vesela Todorova Mitkova-Hristova Source Type: research
Cutaneous adverse drug reactions
Therapie. 2023 Oct 31:S0040-5957(23)00175-0. doi: 10.1016/j.therap.2023.09.011. Online ahead of print.ABSTRACTCutaneous adverse drug reactions (ADRs) represent a heterogeneous field including various clinical patterns without specific features suggesting drug causality. Maculopapular exanthema and urticaria are the most common types of cutaneous ADR. Serious cutaneous ADRs, which may cause permanent sequelae or have fatal outcome, may represent 2% of all cutaneous ADR and must be quickly identified to guide their management. These serious reactions include bullous manifestations (epidermal necrolysis i.e. Stevens-Johnson s...
Source: Therapie - November 18, 2023 Category: Psychiatry & Psychology Authors: Thomas Bettuzzi Paola Sanchez-Pena B énédicte Lebrun-Vignes Source Type: research
Cutaneous adverse drug reactions
Therapie. 2023 Oct 31:S0040-5957(23)00175-0. doi: 10.1016/j.therap.2023.09.011. Online ahead of print.ABSTRACTCutaneous adverse drug reactions (ADRs) represent a heterogeneous field including various clinical patterns without specific features suggesting drug causality. Maculopapular exanthema and urticaria are the most common types of cutaneous ADR. Serious cutaneous ADRs, which may cause permanent sequelae or have fatal outcome, may represent 2% of all cutaneous ADR and must be quickly identified to guide their management. These serious reactions include bullous manifestations (epidermal necrolysis i.e. Stevens-Johnson s...
Source: Therapie - November 18, 2023 Category: Psychiatry & Psychology Authors: Thomas Bettuzzi Paola Sanchez-Pena B énédicte Lebrun-Vignes Source Type: research
Can Smartphone Notifications Help with Gout Management? A Feasibility Study
CONCLUSION: Adherence-targeted notifications have the potential to be an effective and scalable approach to supporting medication adherence in gout patients. Further research is needed with larger samples to refine the components of the intervention and explore its optimal implementation.PMID:37967906 | DOI:10.3899/jrheum.2023-0711 (Source: Cancer Control)
Source: Cancer Control - November 15, 2023 Category: Cancer & Oncology Authors: Yasaman Emad Nicola Dalbeth John Weinman Trudie Chalder Keith J Petrie Source Type: research
Can Smartphone Notifications Help with Gout Management? A Feasibility Study
CONCLUSION: Adherence-targeted notifications have the potential to be an effective and scalable approach to supporting medication adherence in gout patients. Further research is needed with larger samples to refine the components of the intervention and explore its optimal implementation.PMID:37967906 | DOI:10.3899/jrheum.2023-0711 (Source: J Rheumatol)
Source: J Rheumatol - November 15, 2023 Category: Rheumatology Authors: Yasaman Emad Nicola Dalbeth John Weinman Trudie Chalder Keith J Petrie Source Type: research
Can Smartphone Notifications Help with Gout Management? A Feasibility Study
CONCLUSION: Adherence-targeted notifications have the potential to be an effective and scalable approach to supporting medication adherence in gout patients. Further research is needed with larger samples to refine the components of the intervention and explore its optimal implementation.PMID:37967906 | DOI:10.3899/jrheum.2023-0711 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - November 15, 2023 Category: Rheumatology Authors: Yasaman Emad Nicola Dalbeth John Weinman Trudie Chalder Keith J Petrie Source Type: research
Can Smartphone Notifications Help with Gout Management? A Feasibility Study
CONCLUSION: Adherence-targeted notifications have the potential to be an effective and scalable approach to supporting medication adherence in gout patients. Further research is needed with larger samples to refine the components of the intervention and explore its optimal implementation.PMID:37967906 | DOI:10.3899/jrheum.2023-0711 (Source: J Rheumatol)
Source: J Rheumatol - November 15, 2023 Category: Rheumatology Authors: Yasaman Emad Nicola Dalbeth John Weinman Trudie Chalder Keith J Petrie Source Type: research
Can Smartphone Notifications Help with Gout Management? A Feasibility Study
CONCLUSION: Adherence-targeted notifications have the potential to be an effective and scalable approach to supporting medication adherence in gout patients. Further research is needed with larger samples to refine the components of the intervention and explore its optimal implementation.PMID:37967906 | DOI:10.3899/jrheum.2023-0711 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - November 15, 2023 Category: Rheumatology Authors: Yasaman Emad Nicola Dalbeth John Weinman Trudie Chalder Keith J Petrie Source Type: research
Can Smartphone Notifications Help with Gout Management? A Feasibility Study
CONCLUSION: Adherence-targeted notifications have the potential to be an effective and scalable approach to supporting medication adherence in gout patients. Further research is needed with larger samples to refine the components of the intervention and explore its optimal implementation.PMID:37967906 | DOI:10.3899/jrheum.2023-0711 (Source: J Rheumatol)
Source: J Rheumatol - November 15, 2023 Category: Rheumatology Authors: Yasaman Emad Nicola Dalbeth John Weinman Trudie Chalder Keith J Petrie Source Type: research
Can Smartphone Notifications Help with Gout Management? A Feasibility Study
CONCLUSION: Adherence-targeted notifications have the potential to be an effective and scalable approach to supporting medication adherence in gout patients. Further research is needed with larger samples to refine the components of the intervention and explore its optimal implementation.PMID:37967906 | DOI:10.3899/jrheum.2023-0711 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - November 15, 2023 Category: Rheumatology Authors: Yasaman Emad Nicola Dalbeth John Weinman Trudie Chalder Keith J Petrie Source Type: research
Can Smartphone Notifications Help with Gout Management? A Feasibility Study
CONCLUSION: Adherence-targeted notifications have the potential to be an effective and scalable approach to supporting medication adherence in gout patients. Further research is needed with larger samples to refine the components of the intervention and explore its optimal implementation.PMID:37967906 | DOI:10.3899/jrheum.2023-0711 (Source: J Rheumatol)
Source: J Rheumatol - November 15, 2023 Category: Rheumatology Authors: Yasaman Emad Nicola Dalbeth John Weinman Trudie Chalder Keith J Petrie Source Type: research
Can Smartphone Notifications Help with Gout Management? A Feasibility Study
CONCLUSION: Adherence-targeted notifications have the potential to be an effective and scalable approach to supporting medication adherence in gout patients. Further research is needed with larger samples to refine the components of the intervention and explore its optimal implementation.PMID:37967906 | DOI:10.3899/jrheum.2023-0711 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - November 15, 2023 Category: Rheumatology Authors: Yasaman Emad Nicola Dalbeth John Weinman Trudie Chalder Keith J Petrie Source Type: research
