A potential therapeutic agent for the treatment of hyperuricemia and gout: 3,4-Dihydroxy-5-nitrobenzaldehyde phenylthiosemicarbazide
Eur J Pharm Sci. 2024 Apr 21:106778. doi: 10.1016/j.ejps.2024.106778. Online ahead of print.ABSTRACTUric acid, the metabolic product of purines, relies on xanthine oxidase (XOD) for production. XOD is a target for the development of drugs for hyperuricemia (HUA) and gout. Currently, treatment options remain limited for gout patients. 3, 4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a derivative of the natural product protocatechualdehyde with good biological activity. In this work, we identify a DHNB thiosemicarbazide class of compounds that targets XOD. 3,4-Dihydroxy-5-nitrobenzaldehyde phenylthiosemicarbazone can effectively...
Source: European Journal of Pharmaceutical Sciences - April 23, 2024 Category: Drugs & Pharmacology Authors: Xiongying Yu Shuaiwei Ren Jun Zhou Yongcui Liao Yousheng Huang Dong Huanhuan Source Type: research
Influence of pharmacogenomic polymorphisms on allopurinol-induced cutaneous adverse drug reactions in Thai patients
Allopurinol has been causing substantial morbidity and mortality particularly in Asian population by producing cutaneous adverse drug reactions (cADRs). Nonetheless, there are no data describing whether other ... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 23, 2024 Category: Genetics & Stem Cells Authors: Gaidganok Sornsamdang, Patompong Satapornpong, Pimonpan Jinda, Thawinee Jantararoungtong, Napatrupron Koomdee, Therdpong Tempark, Jettanong Klaewsongkram, Ticha Rerkpattanapipat, Pawinee Rerknimitr, Papapit Tuchinda, Leena Chularojanamontri, Napatra Tovan Tags: Research Source Type: research
Xanthine oxidase inhibitory constituents from the roots of < em > Ampelopsis japonica < /em >
Nat Prod Res. 2024 Apr 18:1-10. doi: 10.1080/14786419.2024.2341308. Online ahead of print.ABSTRACTBioassay-guided purification of the xanthine oxidase (XOD) inhibitory extract of the roots of Ampelopsis japonica resulted in the isolation of two new triterpenoids (1-2), designated Ampejaponoside A and B, along with sixteen known compounds (3-18). The structures of Ampejaposide A and B were elucidated by comprehensive analysis of spectroscopic data with the structures of the known compounds 3-18 confirmed by comparison the spectral data with corresponding values reported in literatures. All the isolates were evaluated for th...
Source: Natural Product Research - April 18, 2024 Category: Biochemistry Authors: Yu-Lin Li Fen Liu Li-Yun Zhao Han-Xiang Li Aikebaier Jumai Zhi-Fang Xu Sheng-Xiang Qiu Source Type: research
Xanthine oxidase inhibitory constituents from the roots of < em > Ampelopsis japonica < /em >
Nat Prod Res. 2024 Apr 18:1-10. doi: 10.1080/14786419.2024.2341308. Online ahead of print.ABSTRACTBioassay-guided purification of the xanthine oxidase (XOD) inhibitory extract of the roots of Ampelopsis japonica resulted in the isolation of two new triterpenoids (1-2), designated Ampejaponoside A and B, along with sixteen known compounds (3-18). The structures of Ampejaposide A and B were elucidated by comprehensive analysis of spectroscopic data with the structures of the known compounds 3-18 confirmed by comparison the spectral data with corresponding values reported in literatures. All the isolates were evaluated for th...
Source: Natural Product Research - April 18, 2024 Category: Biochemistry Authors: Yu-Lin Li Fen Liu Li-Yun Zhao Han-Xiang Li Aikebaier Jumai Zhi-Fang Xu Sheng-Xiang Qiu Source Type: research
A case report of acute claudication due to vena cava thromboembolism in a dog naturally infected with Leishmania Infantum
AbstractCanine leishmaniosis is a vector-borne disease caused byLeishmania infantum, and clinical manifestations of infection range from absent or severe to fatal and result from immune-mediated mechanisms. In dogs, the most common clinical signs of leishmaniosis include skin lesions and lymphadenomegaly. However, the presence of other nontypical signs has been described, and diagnosing these cases can be challenging. The aim of the present short communication was to describe the impact of the formation of circulating immunocomplexes due toL. infantum in a dog with leishmaniosis affected by a massive venous thrombus of the...
Source: Veterinary Research Communications - April 17, 2024 Category: Veterinary Research Source Type: research
Knowledge of and stated adherence to the 2020 ACR Guideline for Gout Management: Results of a survey of US rheumatologists
CONCLUSION: The self-reported practice of the surveyed US rheumatologists was generally concordant with the 2020 ACR Guideline for the Management of Gout. However, there were gaps in guideline knowledge and stated adherence among rheumatologists, mainly concerning the dosing of treatment regimens.PMID:38621796 | DOI:10.3899/jrheum.2023-0981 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - April 15, 2024 Category: Rheumatology Authors: Naomi Schlesinger Michael H Pillinger Peter E Lipsky Source Type: research
Knowledge of and stated adherence to the 2020 ACR Guideline for Gout Management: Results of a survey of US rheumatologists
CONCLUSION: The self-reported practice of the surveyed US rheumatologists was generally concordant with the 2020 ACR Guideline for the Management of Gout. However, there were gaps in guideline knowledge and stated adherence among rheumatologists, mainly concerning the dosing of treatment regimens.PMID:38621796 | DOI:10.3899/jrheum.2023-0981 (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2024 Category: Rheumatology Authors: Naomi Schlesinger Michael H Pillinger Peter E Lipsky Source Type: research
Knowledge of and stated adherence to the 2020 ACR Guideline for Gout Management: Results of a survey of US rheumatologists
CONCLUSION: The self-reported practice of the surveyed US rheumatologists was generally concordant with the 2020 ACR Guideline for the Management of Gout. However, there were gaps in guideline knowledge and stated adherence among rheumatologists, mainly concerning the dosing of treatment regimens.PMID:38621796 | DOI:10.3899/jrheum.2023-0981 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - April 15, 2024 Category: Rheumatology Authors: Naomi Schlesinger Michael H Pillinger Peter E Lipsky Source Type: research
Knowledge of and stated adherence to the 2020 ACR Guideline for Gout Management: Results of a survey of US rheumatologists
CONCLUSION: The self-reported practice of the surveyed US rheumatologists was generally concordant with the 2020 ACR Guideline for the Management of Gout. However, there were gaps in guideline knowledge and stated adherence among rheumatologists, mainly concerning the dosing of treatment regimens.PMID:38621796 | DOI:10.3899/jrheum.2023-0981 (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2024 Category: Rheumatology Authors: Naomi Schlesinger Michael H Pillinger Peter E Lipsky Source Type: research
Knowledge of and stated adherence to the 2020 ACR Guideline for Gout Management: Results of a survey of US rheumatologists
CONCLUSION: The self-reported practice of the surveyed US rheumatologists was generally concordant with the 2020 ACR Guideline for the Management of Gout. However, there were gaps in guideline knowledge and stated adherence among rheumatologists, mainly concerning the dosing of treatment regimens.PMID:38621796 | DOI:10.3899/jrheum.2023-0981 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - April 15, 2024 Category: Rheumatology Authors: Naomi Schlesinger Michael H Pillinger Peter E Lipsky Source Type: research
Knowledge of and stated adherence to the 2020 ACR Guideline for Gout Management: Results of a survey of US rheumatologists
CONCLUSION: The self-reported practice of the surveyed US rheumatologists was generally concordant with the 2020 ACR Guideline for the Management of Gout. However, there were gaps in guideline knowledge and stated adherence among rheumatologists, mainly concerning the dosing of treatment regimens.PMID:38621796 | DOI:10.3899/jrheum.2023-0981 (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2024 Category: Rheumatology Authors: Naomi Schlesinger Michael H Pillinger Peter E Lipsky Source Type: research
Knowledge of and stated adherence to the 2020 ACR Guideline for Gout Management: Results of a survey of US rheumatologists
CONCLUSION: The self-reported practice of the surveyed US rheumatologists was generally concordant with the 2020 ACR Guideline for the Management of Gout. However, there were gaps in guideline knowledge and stated adherence among rheumatologists, mainly concerning the dosing of treatment regimens.PMID:38621796 | DOI:10.3899/jrheum.2023-0981 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - April 15, 2024 Category: Rheumatology Authors: Naomi Schlesinger Michael H Pillinger Peter E Lipsky Source Type: research
Knowledge of and stated adherence to the 2020 ACR Guideline for Gout Management: Results of a survey of US rheumatologists
CONCLUSION: The self-reported practice of the surveyed US rheumatologists was generally concordant with the 2020 ACR Guideline for the Management of Gout. However, there were gaps in guideline knowledge and stated adherence among rheumatologists, mainly concerning the dosing of treatment regimens.PMID:38621796 | DOI:10.3899/jrheum.2023-0981 (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2024 Category: Rheumatology Authors: Naomi Schlesinger Michael H Pillinger Peter E Lipsky Source Type: research
Knowledge of and stated adherence to the 2020 ACR Guideline for Gout Management: Results of a survey of US rheumatologists
CONCLUSION: The self-reported practice of the surveyed US rheumatologists was generally concordant with the 2020 ACR Guideline for the Management of Gout. However, there were gaps in guideline knowledge and stated adherence among rheumatologists, mainly concerning the dosing of treatment regimens.PMID:38621796 | DOI:10.3899/jrheum.2023-0981 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - April 15, 2024 Category: Rheumatology Authors: Naomi Schlesinger Michael H Pillinger Peter E Lipsky Source Type: research
Knowledge of and stated adherence to the 2020 ACR Guideline for Gout Management: Results of a survey of US rheumatologists
CONCLUSION: The self-reported practice of the surveyed US rheumatologists was generally concordant with the 2020 ACR Guideline for the Management of Gout. However, there were gaps in guideline knowledge and stated adherence among rheumatologists, mainly concerning the dosing of treatment regimens.PMID:38621796 | DOI:10.3899/jrheum.2023-0981 (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2024 Category: Rheumatology Authors: Naomi Schlesinger Michael H Pillinger Peter E Lipsky Source Type: research
