Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study
Haematologica. 2024 Feb 15. doi: 10.3324/haematol.2023.284390. Online ahead of print.ABSTRACTAllopurinol can be used in maintenance therapy (MT) for pediatric acute lymphoblastic leukemia (ALL) to mitigate hepatic toxicity in patients with skewed 6- mercaptopurine metabolism. Allopurinol increases the erythrocyte levels of thioguanine nucleotides (e-TGN), which is the proposed main mediator of the antileukemic effect and decreases methyl mercaptopurine (e-MeMP) levels, associated with hepatotoxicity. We investigated the effects of allopurinol in thiopurine methyltransferase (TPMT) wild-type patients without previous clinic...
Source: Haematologica - February 15, 2024 Category: Hematology Authors: Jonatan K ällström Riita Niinim äki Johan Fredlund Hartmut Vogt Laura Korhonen Anders Castor Josefine Palle Arja Harila Magnus Borss én Jonas Abrahamsson Torben Ek Source Type: research
Treatment of Cutaneous Leishmaniasis lesion caused by Leishmania major Using Leech Therapy in BALB/c Mice
CONCLUSION: Considering the fact that the standard drugs for the treatment of leishmaniasis have many side effects, alternative therapies such as leech therapy can be effectively used to treat these chronic wounds. There are about 20 active substances in leech saliva. These substances include antistasin, eglins, guamerin, hirudin, saratin, bdellins, complement, and carboxypeptidase inhibitors. Leech saliva is an anticoagulant, anti-inflammation and prevents the platelet. Leech therapy was effective in treating leishmaniasis wounds in BALB/c mice. In this study, there was complete wound healing in 56% of the mice models.PMI...
Source: Journal of Vector Borne Diseases - February 15, 2024 Category: Infectious Diseases Authors: Leila Shirani-Bidabadi Source Type: research
Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study
Haematologica. 2024 Feb 15. doi: 10.3324/haematol.2023.284390. Online ahead of print.ABSTRACTAllopurinol can be used in maintenance therapy (MT) for pediatric acute lymphoblastic leukemia (ALL) to mitigate hepatic toxicity in patients with skewed 6- mercaptopurine metabolism. Allopurinol increases the erythrocyte levels of thioguanine nucleotides (e-TGN), which is the proposed main mediator of the antileukemic effect and decreases methyl mercaptopurine (e-MeMP) levels, associated with hepatotoxicity. We investigated the effects of allopurinol in thiopurine methyltransferase (TPMT) wild-type patients without previous clinic...
Source: Haematologica - February 15, 2024 Category: Hematology Authors: Jonatan K ällström Riita Niinim äki Johan Fredlund Hartmut Vogt Laura Korhonen Anders Castor Josefine Palle Arja Harila Magnus Borss én Jonas Abrahamsson Torben Ek Source Type: research
Treatment of Cutaneous Leishmaniasis lesion caused by Leishmania major Using Leech Therapy in BALB/c Mice
CONCLUSION: Considering the fact that the standard drugs for the treatment of leishmaniasis have many side effects, alternative therapies such as leech therapy can be effectively used to treat these chronic wounds. There are about 20 active substances in leech saliva. These substances include antistasin, eglins, guamerin, hirudin, saratin, bdellins, complement, and carboxypeptidase inhibitors. Leech saliva is an anticoagulant, anti-inflammation and prevents the platelet. Leech therapy was effective in treating leishmaniasis wounds in BALB/c mice. In this study, there was complete wound healing in 56% of the mice models.PMI...
Source: Journal of Vector Borne Diseases - February 15, 2024 Category: Infectious Diseases Authors: Leila Shirani-Bidabadi Source Type: research
Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study
Haematologica. 2024 Feb 15. doi: 10.3324/haematol.2023.284390. Online ahead of print.ABSTRACTAllopurinol can be used in maintenance therapy (MT) for pediatric acute lymphoblastic leukemia (ALL) to mitigate hepatic toxicity in patients with skewed 6- mercaptopurine metabolism. Allopurinol increases the erythrocyte levels of thioguanine nucleotides (e-TGN), which is the proposed main mediator of the antileukemic effect and decreases methyl mercaptopurine (e-MeMP) levels, associated with hepatotoxicity. We investigated the effects of allopurinol in thiopurine methyltransferase (TPMT) wild-type patients without previous clinic...
Source: Haematologica - February 15, 2024 Category: Hematology Authors: Jonatan K ällström Riita Niinim äki Johan Fredlund Hartmut Vogt Laura Korhonen Anders Castor Josefine Palle Arja Harila Magnus Borss én Jonas Abrahamsson Torben Ek Source Type: research
Treatment of Cutaneous Leishmaniasis lesion caused by Leishmania major Using Leech Therapy in BALB/c Mice
CONCLUSION: Considering the fact that the standard drugs for the treatment of leishmaniasis have many side effects, alternative therapies such as leech therapy can be effectively used to treat these chronic wounds. There are about 20 active substances in leech saliva. These substances include antistasin, eglins, guamerin, hirudin, saratin, bdellins, complement, and carboxypeptidase inhibitors. Leech saliva is an anticoagulant, anti-inflammation and prevents the platelet. Leech therapy was effective in treating leishmaniasis wounds in BALB/c mice. In this study, there was complete wound healing in 56% of the mice models.PMI...
Source: Journal of Vector Borne Diseases - February 15, 2024 Category: Infectious Diseases Authors: Leila Shirani-Bidabadi Source Type: research
Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study
Haematologica. 2024 Feb 15. doi: 10.3324/haematol.2023.284390. Online ahead of print.ABSTRACTAllopurinol can be used in maintenance therapy (MT) for pediatric acute lymphoblastic leukemia (ALL) to mitigate hepatic toxicity in patients with skewed 6- mercaptopurine metabolism. Allopurinol increases the erythrocyte levels of thioguanine nucleotides (e-TGN), which is the proposed main mediator of the antileukemic effect and decreases methyl mercaptopurine (e-MeMP) levels, associated with hepatotoxicity. We investigated the effects of allopurinol in thiopurine methyltransferase (TPMT) wild-type patients without previous clinic...
Source: Haematologica - February 15, 2024 Category: Hematology Authors: Jonatan K ällström Riita Niinim äki Johan Fredlund Hartmut Vogt Laura Korhonen Anders Castor Josefine Palle Arja Harila Magnus Borss én Jonas Abrahamsson Torben Ek Source Type: research
Treatment of Cutaneous Leishmaniasis lesion caused by Leishmania major Using Leech Therapy in BALB/c Mice
CONCLUSION: Considering the fact that the standard drugs for the treatment of leishmaniasis have many side effects, alternative therapies such as leech therapy can be effectively used to treat these chronic wounds. There are about 20 active substances in leech saliva. These substances include antistasin, eglins, guamerin, hirudin, saratin, bdellins, complement, and carboxypeptidase inhibitors. Leech saliva is an anticoagulant, anti-inflammation and prevents the platelet. Leech therapy was effective in treating leishmaniasis wounds in BALB/c mice. In this study, there was complete wound healing in 56% of the mice models.PMI...
Source: Journal of Vector Borne Diseases - February 15, 2024 Category: Infectious Diseases Authors: Leila Shirani-Bidabadi Source Type: research
Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study
Haematologica. 2024 Feb 15. doi: 10.3324/haematol.2023.284390. Online ahead of print.ABSTRACTAllopurinol can be used in maintenance therapy (MT) for pediatric acute lymphoblastic leukemia (ALL) to mitigate hepatic toxicity in patients with skewed 6- mercaptopurine metabolism. Allopurinol increases the erythrocyte levels of thioguanine nucleotides (e-TGN), which is the proposed main mediator of the antileukemic effect and decreases methyl mercaptopurine (e-MeMP) levels, associated with hepatotoxicity. We investigated the effects of allopurinol in thiopurine methyltransferase (TPMT) wild-type patients without previous clinic...
Source: Haematologica - February 15, 2024 Category: Hematology Authors: Jonatan K ällström Riita Niinim äki Johan Fredlund Hartmut Vogt Laura Korhonen Anders Castor Josefine Palle Arja Harila Magnus Borss én Jonas Abrahamsson Torben Ek Source Type: research
Lipidomics Analysis Deepen Understanding the Molecular Mechanisms in a Gouty Model Induced by Combination of MSU Crystals Injection and High-Fat Diet Feeding and the Intervention Mechanisms of Allopurinol
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - February 13, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
Effect of Febuxostat versus Allopurinol on the Glomerular Filtration Rate and Hyperuricemia in Patients with Chronic Kidney Disease
Saudi J Kidney Dis Transpl. 2023 Jul 1;34(4):279-287. doi: 10.4103/1319-2442.395443. Epub 2024 Feb 12.ABSTRACTHyperuricemia is a risk factor for the progression of chronic kidney disease (CKD). We compared febuxostat versus allopurinol in the progression of CKD and hyperuricemia in 101 patients with Stage 3-4 CKD treated with febuxostat or allopurinol for at least 6 months for hyperuricemia (>7 mg/dL) between January 2012 and December 2016. Baseline characteristics, serum uric acid (SUA), serum creatinine, and estimated glomerular filtration rate (eGFR) at entry and 6 months were compared. The primary outcome was the de...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Shankar Prasad Nagaraju Srinivas Vinayak Shenoy Indu Rao Ravindra Attur Prabhu Dharshan Rangaswamy Mohan V Bhojaraja Vasudeva Guddattu Source Type: research
Effect of Febuxostat versus Allopurinol on the Glomerular Filtration Rate and Hyperuricemia in Patients with Chronic Kidney Disease
Saudi J Kidney Dis Transpl. 2023 Jul 1;34(4):279-287. doi: 10.4103/1319-2442.395443. Epub 2024 Feb 12.ABSTRACTHyperuricemia is a risk factor for the progression of chronic kidney disease (CKD). We compared febuxostat versus allopurinol in the progression of CKD and hyperuricemia in 101 patients with Stage 3-4 CKD treated with febuxostat or allopurinol for at least 6 months for hyperuricemia (>7 mg/dL) between January 2012 and December 2016. Baseline characteristics, serum uric acid (SUA), serum creatinine, and estimated glomerular filtration rate (eGFR) at entry and 6 months were compared. The primary outcome was the de...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Shankar Prasad Nagaraju Srinivas Vinayak Shenoy Indu Rao Ravindra Attur Prabhu Dharshan Rangaswamy Mohan V Bhojaraja Vasudeva Guddattu Source Type: research
Effect of Febuxostat versus Allopurinol on the Glomerular Filtration Rate and Hyperuricemia in Patients with Chronic Kidney Disease
Saudi J Kidney Dis Transpl. 2023 Jul 1;34(4):279-287. doi: 10.4103/1319-2442.395443. Epub 2024 Feb 12.ABSTRACTHyperuricemia is a risk factor for the progression of chronic kidney disease (CKD). We compared febuxostat versus allopurinol in the progression of CKD and hyperuricemia in 101 patients with Stage 3-4 CKD treated with febuxostat or allopurinol for at least 6 months for hyperuricemia (>7 mg/dL) between January 2012 and December 2016. Baseline characteristics, serum uric acid (SUA), serum creatinine, and estimated glomerular filtration rate (eGFR) at entry and 6 months were compared. The primary outcome was the de...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Shankar Prasad Nagaraju Srinivas Vinayak Shenoy Indu Rao Ravindra Attur Prabhu Dharshan Rangaswamy Mohan V Bhojaraja Vasudeva Guddattu Source Type: research
Effect of Febuxostat versus Allopurinol on the Glomerular Filtration Rate and Hyperuricemia in Patients with Chronic Kidney Disease
Saudi J Kidney Dis Transpl. 2023 Jul 1;34(4):279-287. doi: 10.4103/1319-2442.395443. Epub 2024 Feb 12.ABSTRACTHyperuricemia is a risk factor for the progression of chronic kidney disease (CKD). We compared febuxostat versus allopurinol in the progression of CKD and hyperuricemia in 101 patients with Stage 3-4 CKD treated with febuxostat or allopurinol for at least 6 months for hyperuricemia (>7 mg/dL) between January 2012 and December 2016. Baseline characteristics, serum uric acid (SUA), serum creatinine, and estimated glomerular filtration rate (eGFR) at entry and 6 months were compared. The primary outcome was the de...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Shankar Prasad Nagaraju Srinivas Vinayak Shenoy Indu Rao Ravindra Attur Prabhu Dharshan Rangaswamy Mohan V Bhojaraja Vasudeva Guddattu Source Type: research
Effect of Febuxostat versus Allopurinol on the Glomerular Filtration Rate and Hyperuricemia in Patients with Chronic Kidney Disease
Saudi J Kidney Dis Transpl. 2023 Jul 1;34(4):279-287. doi: 10.4103/1319-2442.395443. Epub 2024 Feb 12.ABSTRACTHyperuricemia is a risk factor for the progression of chronic kidney disease (CKD). We compared febuxostat versus allopurinol in the progression of CKD and hyperuricemia in 101 patients with Stage 3-4 CKD treated with febuxostat or allopurinol for at least 6 months for hyperuricemia (>7 mg/dL) between January 2012 and December 2016. Baseline characteristics, serum uric acid (SUA), serum creatinine, and estimated glomerular filtration rate (eGFR) at entry and 6 months were compared. The primary outcome was the de...
Source: Saudi Journal of Kidney Diseases and Transplantation - February 12, 2024 Category: Urology & Nephrology Authors: Shankar Prasad Nagaraju Srinivas Vinayak Shenoy Indu Rao Ravindra Attur Prabhu Dharshan Rangaswamy Mohan V Bhojaraja Vasudeva Guddattu Source Type: research
