Repurposing HLA genotype data of renal transplant patients to prevent severe drug hypersensitivity reactions
This study aims to investigate the feasibility and potential impact of repurposing these HLA genotype data from kidney transplant patients to prevent drug hypersensitivity reactions.Methods: A cohort of 1347 kidney transplant recipients has been genotyped in the Leiden University Medical Center (LUMC) using next-generation sequencing (NGS). The risk alleles HLA-A*31:01, HLA-B*15:02, HLA-B*15:11, HLA-B*57:01, and HLA-B*58:01 were retrieved from the NGS data. Medical history, medication use, and allergic reactions were obtained from the patient’s medical records. Carrier frequencies found were compared to a LUMC blood dono...
Source: Frontiers in Genetics - October 16, 2023 Category: Genetics & Stem Cells Source Type: research
Urate-Lowering Drugs And Muscle Injury: A Systematic Review and Network Meta-Analysis
This study investigated the association of oral urate-lowering drugs with the risk of muscle injury by performing a network meta-analysis of randomized and non-randomized controlled trials. A systematic search of MEDLINE via PubMed, the ClinicalTrials.gov website, and the Cochrane Central Register of Controlled Trials was conducted to identify relevant studies with a primary outcome of "all muscle injuries." A random-effects model was used to perform a frequentist network meta-analysis to estimate whether there was significant heterogeneity among the studies. In total, 32 studies including 28,327 participants with 2,694 (9...
Source: The Journal of Clinical Pharmacology - October 15, 2023 Category: Drugs & Pharmacology Authors: Satoru Mitsuboshi Makoto Morizumi Kazumasa Kotake Ryohei Kaseda Ichiei Narita Source Type: research
Urate-Lowering Drugs And Muscle Injury: A Systematic Review and Network Meta-Analysis
This study investigated the association of oral urate-lowering drugs with the risk of muscle injury by performing a network meta-analysis of randomized and non-randomized controlled trials. A systematic search of MEDLINE via PubMed, the ClinicalTrials.gov website, and the Cochrane Central Register of Controlled Trials was conducted to identify relevant studies with a primary outcome of "all muscle injuries." A random-effects model was used to perform a frequentist network meta-analysis to estimate whether there was significant heterogeneity among the studies. In total, 32 studies including 28,327 participants with 2,694 (9...
Source: The Journal of Clinical Pharmacology - October 15, 2023 Category: Drugs & Pharmacology Authors: Satoru Mitsuboshi Makoto Morizumi Kazumasa Kotake Ryohei Kaseda Ichiei Narita Source Type: research
Urate-Lowering Drugs And Muscle Injury: A Systematic Review and Network Meta-Analysis
This study investigated the association of oral urate-lowering drugs with the risk of muscle injury by performing a network meta-analysis of randomized and non-randomized controlled trials. A systematic search of MEDLINE via PubMed, the ClinicalTrials.gov website, and the Cochrane Central Register of Controlled Trials was conducted to identify relevant studies with a primary outcome of "all muscle injuries." A random-effects model was used to perform a frequentist network meta-analysis to estimate whether there was significant heterogeneity among the studies. In total, 32 studies including 28,327 participants with 2,694 (9...
Source: The Journal of Clinical Pharmacology - October 15, 2023 Category: Drugs & Pharmacology Authors: Satoru Mitsuboshi Makoto Morizumi Kazumasa Kotake Ryohei Kaseda Ichiei Narita Source Type: research
Emerging Urate-Lowering Drugs and Pharmacologic Treatment Strategies for Gout: A Narrative Review
Drugs. 2023 Oct 11. doi: 10.1007/s40265-023-01944-y. Online ahead of print.ABSTRACTHyperuricemia with consequent monosodium urate crystal deposition leads to gout, characterized by painful, incapacitating inflammatory arthritis flares that are also associated with increased cardiovascular event and related mortality risk. This narrative review focuses on emerging pharmacologic urate-lowering treatment (ULT) and management strategies in gout. Undertreated, gout can progress to palpable tophi and joint damage. In oral ULT clinical trials, target serum urate of < 6.0 mg/dL can be achieved in ~ 80-90% of subjects, with flar...
Source: Atherosclerosis - October 11, 2023 Category: Cardiology Authors: Robert Terkeltaub Source Type: research
Emerging Urate-Lowering Drugs and Pharmacologic Treatment Strategies for Gout: A Narrative Review
AbstractHyperuricemia with consequent monosodium urate crystal deposition leads to gout, characterized by painful, incapacitating inflammatory arthritis flares that are also associated with increased cardiovascular event and related mortality risk. This narrative review focuses on emerging pharmacologic urate-lowering treatment (ULT) and management strategies in gout. Undertreated, gout can progress to palpable tophi and joint damage. In oral ULT clinical trials, target serum urate of< 6.0 mg/dL can be achieved in ~ 80 –90% of subjects, with flare burden reduction by 1–2 years. However, real-world ULT results are fa...
Source: Drugs - October 11, 2023 Category: Drugs & Pharmacology Source Type: research
Allopurinol Prevents Cirrhosis-Related Complications: A Quadruple Blind Placebo-Controlled Trial
: Complications associated with liver cirrhosis are various and potentially fatal. The treatment options to counteract hepatic decompensation are limited. Therefore, the study aimed to explore the use of allopurinol in preventing the recurrence of liver cirrhosis-related complications. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - October 11, 2023 Category: General Medicine Authors: Khadija A.M. Glal, Sahar M. El-Haggar, Sherief M. Abd-Elsalam, Tarek M. Mostafa Tags: Clinical Research Study Source Type: research
Emerging Urate-Lowering Drugs and Pharmacologic Treatment Strategies for Gout: A Narrative Review
AbstractHyperuricemia with consequent monosodium urate crystal deposition leads to gout, characterized by painful, incapacitating inflammatory arthritis flares that are also associated with increased cardiovascular event and related mortality risk. This narrative review focuses on emerging pharmacologic urate-lowering treatment (ULT) and management strategies in gout. Undertreated, gout can progress to palpable tophi and joint damage. In oral ULT clinical trials, target serum urate of< 6.0 mg/dL can be achieved in ~ 80 –90% of subjects, with flare burden reduction by 1–2 years. However, real-world ULT results are fa...
Source: Drugs - October 11, 2023 Category: Drugs & Pharmacology Source Type: research
A Systematic Review and Meta-analysis of Randomized Clinical Trials on the Prevention and Treatment of Pouchitis after Ileoanal Pouch Anastomosis
ConclusionsProbiotics are effective in preventing pouchitis after IPAA. Antibiotics, including ciprofloxacin and metronidazole, are likely effective in treating active pouchitis. (Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - October 10, 2023 Category: Surgery Source Type: research
Allopurinol-Induced Stevens-Johnson Syndrome (SJS)
We describe a case of allopurinol-induced SJS in a 95-year-old Asian female. The patient started allopurinol 13 days prior to presenting to the emergency room (ER). On day 10 of therapy, the patient developed a diffuse erythematous desquamating rash which prompted her to visit the ER after 3 days from the rash onset. This case report describes a rare fatal hypersensitivity reaction that requires rapid identification and treatment in a multi-disciplinary setting.PMID:37811521 | PMC:PMC10557962 | DOI:10.2147/CPAA.S427714 (Source: Clinical Pharmacology: Advances and Applications)
Source: Clinical Pharmacology: Advances and Applications - October 9, 2023 Category: Allergy & Immunology Authors: Takla R Anis John Meher Source Type: research
