Urate-Lowering Drugs And Muscle Injury: A Systematic Review and Network Meta-Analysis

This study investigated the association of oral urate-lowering drugs with the risk of muscle injury by performing a network meta-analysis of randomized and non-randomized controlled trials. A systematic search of MEDLINE via PubMed, the ClinicalTrials.gov website, and the Cochrane Central Register of Controlled Trials was conducted to identify relevant studies with a primary outcome of "all muscle injuries." A random-effects model was used to perform a frequentist network meta-analysis to estimate whether there was significant heterogeneity among the studies. In total, 32 studies including 28,327 participants with 2,694 (9.5%) "all muscle injuries" were assessed, and the overall risk of bias was judged to be low to moderate. No statistically significant differences were found between placebo and six urate-lowering therapies: allopurinol (risk ratio [RR] 1.05, 95% confidence interval [CI] 0.63-1.73), febuxostat (RR 1.10, 95% CI 0.71-1.70), lesinurad (RR 7.00, 95% CI 0.31-160.36), lesinurad concomitant with allopurinol (RR 0.85, 95% CI 0.34-2.11), lesinurad concomitant with febuxostat (RR 1.97, 95% CI 0.55-7.03), and topiroxostat (RR 0.99, 95% CI 0.37-2.65). The findings suggest that there is little need to consider the risk of muscle injury when using urate-lowering drugs in the clinical setting. This article is protected by copyright. All rights reserved.PMID:37840156 | DOI:10.1002/jcph.2369
Source: The Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research