Allopurinol and blood pressure variability following ischemic stroke and transient ischemic attack: a secondary analysis of XILO-FIST
Journal of Human Hypertension, Published online: 04 March 2024; doi:10.1038/s41371-024-00906-5Allopurinol and blood pressure variability following ischemic stroke and transient ischemic attack: a secondary analysis of XILO-FIST (Source: Journal of Human Hypertension)
Source: Journal of Human Hypertension - March 4, 2024 Category: Cardiology Authors: Alexander S. MACDONALD Alex MCCONNACHIE David Alexander DICKIE Philip M. BATH Kirsten FORBES Terence QUINN Niall M. BROOMFIELD Krishna DANI Alex DONEY Keith W. MUIR Allan STRUTHERS Matthew WALTERS Mark BARBER Ajay BHALLA Alan CAMERON Paul GUYLER Ahamad HA Source Type: research
Allopurinol
(Source: Reactions Weekly)
Source: Reactions Weekly - March 1, 2024 Category: Drugs & Pharmacology Source Type: research
Assessment of drug utilization and potentially inappropriate medications in hemodialysis patients with end-stage renal dysfunction: A study in a tertiary care hospital in Bahrain
CONCLUSION: A huge burden of drug therapy was observed in the hemodialysis patients in terms of higher proportions of PIM, complex medical regimen, and prescription of drugs with risk of TdP. Implementation of clinical decision support tools enhancing rational prescription and identification of drugs with TdP risk, introducing antimicrobial stewardship, and stepwise deprescription of the drugs with the least benefit-risk ratio are warranted.PMID:38393922 | DOI:10.3233/JRS-230004 (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - February 23, 2024 Category: Drugs & Pharmacology Authors: Kannan Sridharan Source Type: research
Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study
Haematologica. 2024 Feb 15. doi: 10.3324/haematol.2023.284390. Online ahead of print.ABSTRACTAllopurinol can be used in maintenance therapy (MT) for pediatric acute lymphoblastic leukemia (ALL) to mitigate hepatic toxicity in patients with skewed 6- mercaptopurine metabolism. Allopurinol increases the erythrocyte levels of thioguanine nucleotides (e-TGN), which is the proposed main mediator of the antileukemic effect and decreases methyl mercaptopurine (e-MeMP) levels, associated with hepatotoxicity. We investigated the effects of allopurinol in thiopurine methyltransferase (TPMT) wild-type patients without previous clinic...
Source: Haematologica - February 15, 2024 Category: Hematology Authors: Jonatan K ällström Riita Niinim äki Johan Fredlund Hartmut Vogt Laura Korhonen Anders Castor Josefine Palle Arja Harila Magnus Borss én Jonas Abrahamsson Torben Ek Source Type: research
Treatment of Cutaneous Leishmaniasis lesion caused by Leishmania major Using Leech Therapy in BALB/c Mice
CONCLUSION: Considering the fact that the standard drugs for the treatment of leishmaniasis have many side effects, alternative therapies such as leech therapy can be effectively used to treat these chronic wounds. There are about 20 active substances in leech saliva. These substances include antistasin, eglins, guamerin, hirudin, saratin, bdellins, complement, and carboxypeptidase inhibitors. Leech saliva is an anticoagulant, anti-inflammation and prevents the platelet. Leech therapy was effective in treating leishmaniasis wounds in BALB/c mice. In this study, there was complete wound healing in 56% of the mice models.PMI...
Source: Journal of Vector Borne Diseases - February 15, 2024 Category: Infectious Diseases Authors: Leila Shirani-Bidabadi Source Type: research
