Biomarkers and clinical outcomes after tezepelumab cessation: extended follow-up from the 2-year DESTINATION study
CONCLUSION: This analysis demonstrates benefits of continued tezepelumab treatment in the management of patients with severe, uncontrolled asthma, compared with stopping treatment after 2 years.PMID:38697286 | DOI:10.1016/j.anai.2024.04.031 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Christopher E Brightling Marco Caminati Jean-Pierre Llanos Scott Caveney Ales Kotalik Janet M Griffiths Anna Lundahl Elliot Israel Ian D Pavord Michael E Wechsler Celeste Porsbjerg Jonathan Corren Monika Go łąbek Neil Martin Sandhia Ponnarambil Source Type: research
The Age Specific Microbiome of Children with Milk, Egg, and Peanut Allergy
CONCLUSION: Dysbiosis associates with food allergy, most prominent in peanut-allergic older children. Younger children with and without food allergy have fewer differences in gut microbiota. This correlates with clinical observations of persistence of peanut allergy, and improved efficacy and safety of oral immunotherapy in younger children. Age under 3 should be considered when initiating therapeutic interventions.PMID:38697287 | DOI:10.1016/j.anai.2024.04.028 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Punita Ponda Jane E Cerise Brianne Navetta-Modrov Jamie Kiehm Grace M Covelli Jared Weiss Annette T Lee Source Type: research
Endovascular coils extrusion after internal carotid artery occlusion: From management to follow ‐up
Key points
ICA coil extrusion (ICA-CE) occurs most frequently in the nasopharyngeal/sinonasal site.
Evaluating the ICA coils stability, through an angiography, is of primary importance.
ICA-CE management needs to be decided based on the patient's symptoms and general status. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - May 2, 2024 Category: Allergy & Immunology Authors: Alessandro Vinciguerra,
Mario Turri ‐Zanoni,
Marco Ferrari,
Davide Mattavelli,
Andrea Giorgianni,
Enrico Fazio,
Francesco Di Pierro,
Vittorio Rampinelli,
Luca Gazzini,
Benjamin Verillaud,
Alberto Schreiber,
Luca Calabrese,
Maurizio Bignami, Tags: CLINICAL LETTER Source Type: research
House lawmakers on both sides grill head of nonprofit that worked with Chinese virologists
Will the EcoHealth Alliance, the U.S. organization that collaborated with virologists in China who some suspect of creating the pandemic coronavirus SARS-CoV-2, survive? That’s the looming question after Peter Daszak, the scientist who heads the nonprofit based in New York City, faced 3 hours of grilling and intense criticism today from a House of Representatives panel investigating the origin of the COVID-19 pandemic.
Both Republicans and Democrats on the panel took EcoHealth to task for everything from the late filing of a progress report for a National Institutes of Health (NIH) grant to the safety conditions of...
Source: Science of Aging Knowledge Environment - May 2, 2024 Category: Geriatrics Source Type: research
Methylisothiazolinone-containing paint contributing to mucocutaneous and cutaneous symptoms: A case of aerosolized allergic contact dermatitis
Methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) are common preservatives present in personal, household, and industrial products including water-based paints. These agents have been recognized as significant contributors to what has been termed an “epidemic” of allergic contact dermatitis (ACD)1, 2. In fact, the 2019-2020 North American Contact Dermatitis Group report found that the MI patch test positivity rate (13.8%) was second only to nickel, with high clinical relevance2. The majority of MI reactions are secondary to direct contact e xposure and result in cutaneous-limited symptoms; however, a sma...
Source: Annals of Allergy, Asthma and Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Emma Roellke, Luz Fonacier, Erin Banta Tags: Letters Source Type: research
ALOX15+ M2 macrophages contribute to epithelial remodeling in eosinophilic chronic rhinosinusitis with nasal polyps
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Chang Liu, Kanghua Wang, Wenqin Liu, Jinxiu Zhang, Yunping Fan, Yueqi Sun Source Type: research
IL-4R α signaling promotes barrier-altering oncostatin M and IL-6 production in aspirin-exacerbated respiratory disease
This study demonstrates overproduction of oncostatin M and IL-6 in nasal fluid in aspirin-exacerbated respiratory disease (AERD) and suggests that dupilumab-induced decrease of both oncostatin M and IL-6 contributes to its therapeutic efficacy in AERD. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Chongjia C. Chen, Kathleen M. Buchheit, Pui Y. Lee, Kailey E. Brodeur, Aaqib Sohail, Laura Cho, Carolyn Baloh, Barbara Balestrieri, Mina Derakhshan, Chunli Feng, Joshua A. Boyce, Daniel Dwyer, Tanya M. Laidlaw Source Type: research
The nasal basal cell population shifts towards a diseased phenotype with impaired barrier formation capacity in allergic rhinitis
Capsule summaryNasal basal cells are characterized by a diseased phenotype in allergic rhinitis and in vitro assays demonstrated that this is correlated with impaired barrier formation capacity, highlighting them as an interesting potential therapeutic target. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Emma Ruysseveldt, Brecht Steelant, Tine Wils, Jonathan Cremer, Dominique M.A. Bullens, Peter W. Hellings, Katleen Martens Source Type: research
Advances in COPD imaging using CT and MRI: linkage with lung physiology and clinical outcomes
Recent years have witnessed major advances in lung imaging in patients with COPD. These include significant refinements in images obtained by computed tomography (CT) scans together with the introduction of new techniques and software that aim for obtaining the best image whilst using the lowest possible radiation dose. Magnetic resonance imaging (MRI) has also emerged as a useful radiation-free tool in assessing structural and more importantly functional derangements in patients with well-established COPD and smokers without COPD, even before the existence of overt changes in resting physiological lung function tests. Tog...
Source: European Respiratory Journal - May 2, 2024 Category: Respiratory Medicine Authors: Elbehairy, A. F., Marshall, H., Naish, J. H., Wild, J. M., Parraga, G., Horsley, A., Vestbo, J. Tags: Asthma and allergy State of the Art Source Type: research
Penicillin Allergy Testing and Delabeling for Patients Who Are Prescribed Penicillin: A Systematic Review for a World Health Organization Guideline
AbstractSecondary prevention with penicillin aims to prevent further episodes of acute rheumatic fever and subsequent development of rheumatic heart disease (RHD). Penicillin allergy, self-reported by 10% of the population, can affect secondary prevention programs. We aimed to assess the role for (i) routine penicillin allergy testing and the (ii) safety of penicillin allergy delabeling approaches in this context. We searched MEDLINE, Embase, CENTRAL, ClinicalTrials.gov, WHO ICTRP, ISRCTN, and CPCI-S to identify the relevant reports. We found 2419 records, but no studies addressed our initial question. Following advice fro...
Source: Clinical Reviews in Allergy and Immunology - May 2, 2024 Category: Allergy & Immunology Source Type: research
Mast Cell-Neutrophil Communication Regulates Allergic Diseases
Yakugaku Zasshi. 2024;144(5):483-488. doi: 10.1248/yakushi.23-00154-2.ABSTRACTAllergic diseases (e.g., food allergies) are a growing problem, with increasing numbers of individuals experiencing them worldwide. Congruently, the adverse reactions (e.g., anaphylaxis) associated with the administration of vaccines against emerging infectious diseases such as coronavirus disease 2019 (COVID-19) have become a familiar problem. Allergic diseases, which have a wide variety of symptoms, are difficult to prevent or cure; treatment is currently limited to therapeutic drugs or allergen immunotherapy. Therefore, elucidating new allergi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Ryo Suzuki Source Type: research
Safety and immunogenicity of a polyvalent DNA-protein HIV vaccine with matched Env immunogens delivered as a prime-boost regimen or coadministered in HIV-uninfected adults in the USA (HVTN 124): a phase 1, placebo-controlled, double-blind randomised controlled trial
Lancet HIV. 2024 May;11(5):e285-e299. doi: 10.1016/S2352-3018(24)00036-5.ABSTRACTBACKGROUND: An effective HIV vaccine will most likely need to have potent immunogenicity and broad cross-subtype coverage. The aim of the HIV Vaccine Trials Network (HVTN) 124 was to evaluate safety and immunogenicity of a unique polyvalent DNA-protein HIV vaccine with matching envelope (Env) immunogens.METHODS: HVTN 124 was a randomised, phase 1, placebo-controlled, double-blind study, including participants who were HIV seronegative and aged 18-50 years at low risk for infection. The DNA vaccine comprised five plasmids: four copies expressin...
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Ian Frank Shuying S Li Nicole Grunenberg Edgar T Overton Samuel T Robinson Hua Zheng Kelly E Seaton Jack R Heptinstall Mary A Allen Kenneth H Mayer Daniel A Culver Michael C Keefer Sri Edupuganti Michael N Pensiero Vijay L Mehra Stephen C De Rosa Daryl E Source Type: research
Transport of glycinin, the major soybean allergen, across intestinal epithelial IPEC ‐J2 cell monolayers
The objective of this study was to elucidate the pathway and mechanism of glycinin hydrolysate transport through the intestinal epithelial barrier using IPEC-J2 cell model. Purified glycinin was digested by in vitro static digestion model. The pathway and mechanism of glycinin hydrolysates transport through intestinal epithelial cells were investigated by cellular transcytosis assay, cellul ar uptake assay, immunoelectron microscopy and endocytosis inhibition assay. The glycinin hydrolysates were transported across IPEC-J2 cell monolayers in a time/dose-dependent manner following the Michaelis equation. Immunoelectron mi...
Source: Journal of Animal Physiology and Animal Nutrition - May 1, 2024 Category: Zoology Authors: Ziang Zheng,
Yintong Zhao,
Shugui Zheng,
Yajin Liu,
Simiao Liu,
Junfeng Han Tags: ORIGINAL ARTICLE Source Type: research
Information for Readers
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - May 1, 2024 Category: Allergy & Immunology Source Type: research
News & Notes
The Practice Management Workshop is a weekend designed for practicing allergists at every stage of practice and in every employment setting. Take full advantage of this educational opportunity devoted exclusively to the business side of medicine. This year ’s workshop will be held in Denver, CO, from July 12-14 and the topics being presented include billing and coding, government regulations, understanding Medicare, negotiating contracts and more. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - May 1, 2024 Category: Allergy & Immunology Source Type: research
