Clinical and Molecular Correlates of the Index of Severity for Eosinophilic Esophagitis
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - May 13, 2024 Category: Allergy & Immunology Authors: Hiroki Sato, Evan S. Dellon, Seema S. Aceves, Nicoleta C. Arva, Mirna Chehade, Margaret H. Collins, Carla M. Davis, Gary W. Falk, Glenn T. Furuta, Nirmala P. Gonsalves, Sandeep K. Gupta, Ikuo Hirano, Girish Hiremath, David A. Katzka, Paneez Khoury, John L Source Type: research
Scarcity of Medical Ethics Research in Allergy and Immunology: A Review and Call to Action
Medical ethics is relevant to the clinical practice of allergy and immunology regardless of the type of patient, disease state, or practice setting. When engaging in clinical care, performing research, or enacting policies on the accessibility and distribution of healthcare resources, physicians regularly make and justify decisions using the fundamental principles of medical ethics. Thus, knowledge of these principles is paramount for Allergists/Immunologists. To date, there has been a shortage of medical ethics research in allergy and immunology. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 12, 2024 Category: Allergy & Immunology Authors: Timothy M. Buckey, Sheryl A. Mathew, Maria A. Sacta, Andrea J. Apter Tags: Review Source Type: research
Sublingual immunotherapy for allergy to shrimp: the nine-year clinical experience of a Midwest Allergy-Immunology practice
Diet restrictions and fear of adverse reactions put a significant burden on the nutrition, growth and life style of children and adults with food allergies. While various disease-modifying options are pursued,... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - May 11, 2024 Category: Allergy & Immunology Authors: Lydia M. Theodoropoulou and Niamh A. Cullen Tags: Research Source Type: research
Frequencies and predictors of subcutaneous and intraosseous injection with four epinephrine autoinjector devices
To prevent anaphylaxis-associated illness, intramuscular-epinephrine injection is recommended. Subcutaneous injection may reduce efficacy and intraosseous injection promotes morbidity. A few studies suggest that commercially-available thigh-epinephrine autoinjectors (EAIs) may induce subcutaneous/intraosseous injection in some adults. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 11, 2024 Category: Allergy & Immunology Authors: S ébastien LEFEVRE, Christophe GOETZ, Laurent HENNEQUIN, Yinka ZEVERING, Vincent DINOT Tags: Original article Source Type: research
Asthma control in the United States: relationships between short-acting β2-agonist and systemic corticosteroid use
Asthma control assessment is based on impairment (current symptoms) and risk (exacerbation history). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 11, 2024 Category: Allergy & Immunology Authors: Geoffrey Chupp, Kevin R. Murphy, Hitesh N. Gandhi, Ileen Gilbert, Eugene R. Bleecker Tags: Original Article Source Type: research
The role of the environment in allergic skin disease
AbstractPurpose of ReviewThis paper explores how environmental factors influence allergic skin diseases, including atopic dermatitis (AD), contact dermatitis (CD), urticaria, angioedema, and reactions to drugs and insect bites.Recent FindingsResearch indicates a significant impact of environmental elements on allergic skin diseases. High air pollution levels exacerbate symptoms, while climate change contributes to increased skin barrier dysfunction, particularly affecting AD. Allergen prevalence is influenced by climate and pollution. Irritants, like those in detergents and cosmetics, play a major role in CD. Plants also c...
Source: Current Allergy and Asthma Reports - May 11, 2024 Category: Allergy & Immunology Source Type: research
The Riddle of Response to Cutaneous Allergen Exposure in Patients with Atopic Dermatitis
The skin is the largest immunological organ in the body, containing immune cells that play a role in both food allergen sensitization and desensitization. The “dual allergen exposure hypothesis” posits that sensitization to food allergens may occur with cutaneous exposure on inflamed skin, eg, atopic dermatitis (AD), but early oral consumption generally leads to tolerance. However, only one-third of children with AD develop food allergy, suggesting a more complex mechanism for allergen sensitization. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 11, 2024 Category: Allergy & Immunology Authors: Hugh A. Sampson Tags: CME Reviews Source Type: research
Nasal mucosal fibroblasts produce IL-4 to induce Th2 response
This study aims to elucidate the role of nasal mucosal fibroblast-derived IL-4 in the induction of Th2 responses. Nasal mucosal tissues were obtained from surgically removed samples from patients with nasal polyps, whether with or without AR. Fibroblasts were isolated from the tissues by flow cytometry cell sorting, and analyzed by RNA sequencing (RNAseq). The data from RNAseq showed that nasal fibroblasts expressed genes of GATA3, CD80, CD83, CD86, STAT6, IL2, IL4, IL5, IL6, IL13 and costimulatory factor. The data were verified by RT-qPCR. The level of gene activity was positively correlated with those of AR-related cytok...
Source: Innate Immunity - May 10, 2024 Category: Allergy & Immunology Authors: Xianhai Zeng Juanjuan Li Jiangqi Liu Lihua Mo Yu Liu Aizhi Zhang Pingchang Yang Hui Kong Source Type: research
How Far Are We From Achieving Delabeling of False Penicillin/ ß-Lactam Allergy Alerts? A Population Problem
J Investig Allergol Clin Immunol. 2024 May 9:0. doi: 10.18176/jiaci.1004. Online ahead of print.ABSTRACTInterest in finding efficient ways to remove penicillin allergy alerts has grown as a result of awareness of the considerable excess of false-negative diagnoses in patients with penicillin allergy labels (90%-95%), the poorer course with non-ß-lactam antibiotics, the increase in bacterial resistance, and the fact that these problems can affect up to 20% of the population in some countries. The strategies proposed have generated many publications in countries where the number of allergists to conduct such studies is low....
Source: Journal of Investigational Allergology and Clinical Immunology - May 10, 2024 Category: Allergy & Immunology Authors: M A Tejedor-Alonso M Perez-Encinas S Sanz M árquez J J Martinez Simon L Moreno-Nu ñez A Gonzalez-Moreno J Macias-Iglesias A Rosado-Ingelmo Source Type: research
Nasal mucosal fibroblasts produce IL-4 to induce Th2 response
This study aims to elucidate the role of nasal mucosal fibroblast-derived IL-4 in the induction of Th2 responses. Nasal mucosal tissues were obtained from surgically removed samples from patients with nasal polyps, whether with or without AR. Fibroblasts were isolated from the tissues by flow cytometry cell sorting, and analyzed by RNA sequencing (RNAseq). The data from RNAseq showed that nasal fibroblasts expressed genes of GATA3, CD80, CD83, CD86, STAT6, IL2, IL4, IL5, IL6, IL13 and costimulatory factor. The data were verified by RT-qPCR. The level of gene activity was positively correlated with those of AR-related cytok...
Source: Innate Immunity - May 10, 2024 Category: Allergy & Immunology Authors: Xianhai Zeng Juanjuan Li Jiangqi Liu Lihua Mo Yu Liu Aizhi Zhang Pingchang Yang Hui Kong Source Type: research
ChatGPT's performance in dentistry and allergyimmunology assessments: a comparative study
This study aimed to evaluate the performance of ChatGPT 3 and ChatGPT 4 on self-assessment questions for dentistry, through the Swiss Federal Licensing Examination in Dental Medicine (SFLEDM), and allergy and clinical immunology, through the European Examination in Allergy and Clinical Immunology (EEAACI). The second objective was to assess the impact of priming on ChatGPT's performance. The SFLEDM and EEAACI multiple-choice questions from the University of Bern's Institute for Medical Education platform were administered to both ChatGPT versions, with and without priming. Performance was analyzed based on correct response...
Source: Schweizer Monatsschrift fur Zahnmedizin - May 10, 2024 Category: Dentistry Authors: Alexander Fuchs Tina Trachsel Roland Weiger Florin Eggmann Source Type: research
Nasal mucosal fibroblasts produce IL-4 to induce Th2 response
This study aims to elucidate the role of nasal mucosal fibroblast-derived IL-4 in the induction of Th2 responses. Nasal mucosal tissues were obtained from surgically removed samples from patients with nasal polyps, whether with or without AR. Fibroblasts were isolated from the tissues by flow cytometry cell sorting, and analyzed by RNA sequencing (RNAseq). The data from RNAseq showed that nasal fibroblasts expressed genes of GATA3, CD80, CD83, CD86, STAT6, IL2, IL4, IL5, IL6, IL13 and costimulatory factor. The data were verified by RT-qPCR. The level of gene activity was positively correlated with those of AR-related cytok...
Source: Innate Immunity - May 10, 2024 Category: Allergy & Immunology Authors: Xianhai Zeng Juanjuan Li Jiangqi Liu Lihua Mo Yu Liu Aizhi Zhang Pingchang Yang Hui Kong Source Type: research
How Far Are We From Achieving Delabeling of False Penicillin/ ß-Lactam Allergy Alerts? A Population Problem
J Investig Allergol Clin Immunol. 2024 May 9:0. doi: 10.18176/jiaci.1004. Online ahead of print.ABSTRACTInterest in finding efficient ways to remove penicillin allergy alerts has grown as a result of awareness of the considerable excess of false-negative diagnoses in patients with penicillin allergy labels (90%-95%), the poorer course with non-ß-lactam antibiotics, the increase in bacterial resistance, and the fact that these problems can affect up to 20% of the population in some countries. The strategies proposed have generated many publications in countries where the number of allergists to conduct such studies is low....
Source: Journal of Investigational Allergology and Clinical Immunology - May 10, 2024 Category: Allergy & Immunology Authors: M A Tejedor-Alonso M Perez-Encinas S Sanz M árquez J J Martinez Simon L Moreno-Nu ñez A Gonzalez-Moreno J Macias-Iglesias A Rosado-Ingelmo Source Type: research
ChatGPT's performance in dentistry and allergyimmunology assessments: a comparative study
This study aimed to evaluate the performance of ChatGPT 3 and ChatGPT 4 on self-assessment questions for dentistry, through the Swiss Federal Licensing Examination in Dental Medicine (SFLEDM), and allergy and clinical immunology, through the European Examination in Allergy and Clinical Immunology (EEAACI). The second objective was to assess the impact of priming on ChatGPT's performance. The SFLEDM and EEAACI multiple-choice questions from the University of Bern's Institute for Medical Education platform were administered to both ChatGPT versions, with and without priming. Performance was analyzed based on correct response...
Source: Schweizer Monatsschrift fur Zahnmedizin - May 10, 2024 Category: Dentistry Authors: Alexander Fuchs Tina Trachsel Roland Weiger Florin Eggmann Source Type: research
Biological Potential and Therapeutic Effectiveness of Phytoproduct 'Fargesin' in Medicine: Focus on the Potential of an Active Phytochemical of Magnolia fargesii
Recent Adv Inflamm Allergy Drug Discov. 2024 May 9. doi: 10.2174/0127722708286664240429093913. Online ahead of print.ABSTRACTFlos Magnoliae is one of the important medicinal plants in different traditional medicine, including Chinese herbal medicine. Lignans and neolignans, including tetrahydrofurofuran, tetrahydrofuran, and aryltetralin, are present in the Flos Magnoliae species. A wide range of pharmacological activity of Flos Magnoliae has been reported in medicine. Fargesin has been isolated from Magnolia fargesii and is a lignan-class phytochemical. Fargesin has numerous pharmacological activities in medicine, includi...
Source: Adv Data - May 10, 2024 Category: Epidemiology Authors: Kanika Patel Dinesh Kumar Patel Source Type: research
