Personalized CAR-T Cell Therapy
Researchers at the Harvard Wyss Institute and the Dana-Farber Cancer Institute have developed a new method to prepare chimeric antigen receptor-T cells (CAR-T cells) for leukemia patients that could result in more effective treatment. CAR-T cells start life as T cells that are isolated from cancer patients, are stimulated and primed to recognize and attack cancer cells, expanded in number, and then reintroduced to the cancer patient with the goal that the cells will destroy their cancer. However, the technique works better in certain patients, and the researchers behind this latest technique have realized that T-cells from...
Source: Medgadget - February 17, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Oncology harvard wyssinstitute Source Type: blogs
Microglial Autophagy in Parkinson's Disease
Autophagy is the name given to a collection of maintenance processes responsible for clearing waste and damaged proteins and structures from the cell. Autophagy is implicated in aging. It is thought to become dysfunctional and less efficient in cells in aging tissues. Further, evidence suggests that improved autophagy is an important mechanisms in the slowing of aging produced by calorie restriction and a range of other interventions tested in laboratory species. Here, researchers discuss the relationship between aging and autophagy specifically in the context of Parkinson's disease and the role of inflammatory microglia i...
Source: Fight Aging! - February 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Food allergy tragedies: the reality that haunts us
Food should not kill, but in the last three weeks alone, the food allergy community has grappled with three food-induced anaphylaxis deaths. All were young adults in the prime of their lives; one in middle school, another going to a school dance, and one just engaged to the love of her life. No one is
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Food allergy tragedies: the reality that haunts us originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 16, 2023 Category: General Medicine Authors: Lianne Mandelbaum Tags: Conditions Allergies & Immunology Source Type: blogs
MLKL Knockout Slows Some Aspects of Immune Aging
Researchers here report on the results of disabling the MLKL gene involved in necroptosis, a form of programmed cell death. This reduces age-related inflammation in female mice, and delays loss of lymphocyte production in male mice. The changes are not enough to produce differences in apparent signs of aging, such as mortality rate, however. The scientific challenge here lies in linking reduced necroptosis to the observed changes in immune aging, as is usually the case in any change that is broadly related cell survival or fundamental cell activities such as replication. This sort of activity can keep research teams busy f...
Source: Fight Aging! - February 16, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How Omnichannel Messaging Can Solve Headaches for Healthcare Communications
The following is a guest article by Sandro Stupar, Product Management Director at Mitto.
Navigating the healthcare system in America can be byzantine and time-consuming. Despite the many advances in telehealth, mobile apps and walk-in health clinics, patients and caregivers frequently find themselves waiting (often impatiently) in long phone queues to make an appointment, renew a prescription or obtain lab results. There should be a better way.
There is. Increasingly, medical providers are borrowing from the classical marketing playbook and weaving omnichannel messaging into their communications. And, just as it has in o...
Source: EMR and HIPAA - February 14, 2023 Category: Information Technology Authors: Guest Author Tags: Administration Ambulatory Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System Telemedicine and Remote Monitoring Automation Group Communication HealthGrades Improve Patient Outcomes Mitto N Source Type: blogs
Towards Ways to Sabotage the Immune Evasion of Senescent Cells in Aged Tissues
Senescent cells are created constantly throughout life, largely the result of somatic cells reaching the Hayflick limit on cellular replication. In youth, these cells are rapidly removed by the immune system, but this clearance falters in later life for reasons yet to be fully explored. Nonetheless, enough is understood to propose a variety of avenues by which the immune clearance of senescent cells can be improved.
Cellular senescence is a complex process involving a close-to-irreversible arrest of the cell cycle, the acquisition of the senescence-associated secretory phenotype (SASP), as well as profound changes...
Source: Fight Aging! - February 14, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 6th 2023
In conclusion, our study reveals that aging enhances atherosclerosis via increased inflammation of visceral fat. Our study suggests that future therapies targeting the visceral fat may reduce atherosclerosis diseaseburden in the expanding older population.
Is the Gut a Significant Source of Amyloid-β in Alzheimer's Disease?
https://www.fightaging.org/archives/2023/02/is-the-gut-a-significant-source-of-amyloid-%ce%b2-in-alzheimers-disease/
The early stages of Alzheimer's disease are characterized by rising levels of amyloid-β in the brain and the formation of misfolded amyloid aggregates. It is present...
Source: Fight Aging! - February 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Does Mitochondrial Dysfunction Meaningfully Contribute to the Development of Atherosclerosis?
Mitochondria are the power plants of the cell, producing the chemical energy store molecule ATP, but are also integrated into a wide range of fundamental cellular processes. Mitochondrial function declines with age, likely an important contribution to age-related declines in energy-hungry tissues such as the brain and muscles. It is also known that mitochondrial dysfunction can provoke chronic inflammation via the mislocation of mitochondrial DNA into parts of the cell where it will act as a damage-associated molecular pattern. This upregulation of inflammatory signaling is a reasonable proposal for the way in which mitoch...
Source: Fight Aging! - January 30, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Tools, Technology Already Exist for HIEs to Succeed
The following is a guest article by Sonia Chambers, Executive Director at West Virginia Health Information Network.
Infrastructure is available nationally for states to leverage and customize locally for their unique Health Information Exchange needs
Health information exchanges (HIEs) are well-situated to help healthcare organizations achieve three core goals of value-based care: providing better care for individuals, reducing healthcare costs, and improving population health management strategies. But establishing an HIE and finding success can be a tremendous challenge for some states to establish in large measure becau...
Source: EMR and HIPAA - January 13, 2023 Category: Information Technology Authors: Guest Author Tags: Health IT Company Healthcare IT Interoperability IT Infrastructure and Dev Ops Contact Tracing CRISP CRISP Shared Services CSS Federal Healthcare Standards Health Information Exchanges healthcare infrastructure HIE HIEs Local Com Source Type: blogs
Reducing Viral Spread in Schools: France Makes Proactive Move to Measure and Reduce CO2 Levels in School and Daycare
One of my favorite gadgets from the pandemic is the AraNet 4 CO2 monitor. I carry it with me whenever I am curious about an indoor space. This easy-to-use monitor gives a simple red-yellow-green reading of the CO2 level. At a green level (<1000 ppm) it is harder to transmit an airborne viral infection. At a red level (>1400 ppm) it is much easier to catch a virus if someone else in the room is sick.
I use this in restaurants and on airplanes, for instance, to help guide my actions.
As a bonus, CO2 levels also correlate with alertness and productivity. When CO2 levels drift into the yellow range (>1000 ppm), cognit...
Source: Conversations with Dr Greene - January 9, 2023 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog Air Quality Allergies Virus Source Type: blogs
Shawn Drew Gaillard to Direct GMCDB
I’m pleased to announce the selection of Shawn Drew Gaillard, Ph.D., as the new director of our Division of Genetics and Molecular, Cellular, and Developmental Biology (GMCDB). Shawn has been the acting director of the Division since February 2022. She will begin in this new role on January 15.
Shawn joined GMCDB as chief of the Developmental and Cellular Processes Branch in 2019, overseeing grants focused on organismal response to environmental stressors. Prior to this role, she was the research training officer at the National Institute of Allergy and Infectious Diseases, and before that, she was a program director in ...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - January 4, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Director’s Messages Job Announcements NIGMS Staff News Source Type: blogs
Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules.
MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity
https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/
Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, pro...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Weekly Roundup – December 31, 2022
Welcome to our Healthcare IT Today Weekly Roundup. Each week, we’ll be providing a look back at the articles we posted and why they’re important to the healthcare IT community. We hope this gives you a chance to catch up on anything you may have missed during the week.
Measuring Indoor Air Ventilation on a Massive Scale. One of the biggest challenges of public health is measuring proxies for health (such as air quality or wastewater contents) without being obtrusive. Andy Oram spoke to Sam Molyneux at Poppy Health about their promising technology to measure air circulation in enclosed spaces through devices that are in...
Source: EMR and HIPAA - December 31, 2022 Category: Information Technology Authors: Brian Eastwood Tags: #HITsm Healthcare IT Healthcare IT Today Weekly Roundup Source Type: blogs
Notes on the 2022 Longevity Summit at the Buck Institute
The Buck Institute recently hosted the 2022 Longevity Summit, and here find some notes on the event from a participant. The number of conferences dedicated to the field of longevity science is increasing steadily, year after year. The best are those in which one finds a mix of entrepreneurs, scientists, and investors, all networking to advance the state of the art in the treatment of aging as a medical condition.
The Longevity Summit at the Buck Institute, a relatively short two-day geroscience and longevity biotech conference held on December 6-7, was nevertheless densely packed with new research - to the point w...
Source: Fight Aging! - December 28, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Nectar Raises over $24M in Funding to Scale Personalized Allergy Care Platform Nationally
Investment from venture funds Juxtapose, Obvious Ventures, and Harmony Partners will help Nectar launch its comprehensive allergy care program nationwide.
Nectar, an innovative and comprehensive allergy care platform, announced today its $16.5 million Series A round led by Harmony Partners, with meaningful participation from founding partners Juxtapose and Obvious Ventures, who co-built the company with Founding CEO Kenneth Chahine, Ph.D.
Nectar’s latest fundraising round, which builds on their March 2022 seed investment and brings total equity raised to over $24M, will allow the company to invest in three key ...
Source: EMR and HIPAA - December 26, 2022 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT AAPRI Allergy Care Harmony Partners Health IT Funding Health IT Fundings Health IT Investment Imperial College London James Joaquin John Zwetchkenbaum M.D. Juxtapose Kari Nadeau M.D. Ph.D. Kenneth Source Type: blogs
