Fight Aging! Newsletter, July 19th 2021
In this study, we developed the first epigenetic clock for domesticated sheep (Ovis aries), which can predict chronological age with a median absolute error of 5.1 months. We have discovered that castrated male sheep have a decelerated aging rate compared to intact males, mediated at least in part by the removal of androgens.
Furthermore, we identified several androgen-sensitive CpG dinucleotides that become progressively hypomethylated with age in intact males, but remain stable in castrated males and females. Comparable sex-specific methylation differences in MKLN1 also exist in bat skin and a range of mouse tissu...
Source: Fight Aging! - July 18, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
SENS Research Foundation is Hiring Scientists to Work on the Foundations of Human Rejuvenation
The SENS Research Foundation is hiring scientists! This is a chance to work at one of the hubs of the field of aging research, with a highly influential group of researchers and patient advocates. The SENS Research Foundation and its network of allies have played an important role in turning investigation of the mechanisms of aging from a toy field, in which intervention was never considered, into a serious field of translational research that has given rise to a growing biotech industry focused on slowing and reversing the processes of aging. In addition to advocacy, the SENS Research Foundation staff work to unblock slow...
Source: Fight Aging! - July 15, 2021 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
The New Zealand Your Healthcare Summary Looks Like An Interesting Initiative – The #myHR Done Right?
This appeared a few days ago. 450,000 patient records uploaded to Your Health Summary Sunday, 27 June 2021 NEWS - eHealthNews.nz editor Rebecca McBeth Primary care health records of close to half a million patients across Auckland have been uploaded to the shared care record system, Your Health Summary (YHS).
The solution is designed to ensure better continuity of care and safety for patients by ensuring their important health information is accessible by authorised healthcare providers that deliver care in a range of care settings, says YHS clinical director Daniel Calder.
The summary includes i...
Source: Australian Health Information Technology - July 7, 2021 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Answer to Case 645
Answer to Parasite Case of the Week 645:Amblyomma americanumadult female tick.TheOracle nicely described what we are seeing here and its implications: " Given the position of the capitulum, we can immediately argue this is a hard tick (family Ixodidae). Even though we don ' t have a ventral picture, the number of legs, the quite long mouthparths and, more importantly, the white spot on the scutum allow us to diagnose an adult female ofAmblyomma americanum, even though Minnesota isn ' t the expected geographic location. This may possibly reflect the tremendous effects of climate change... TheOracle further c...
Source: Creepy Dreadful Wonderful Parasites - July 4, 2021 Category: Parasitology Source Type: blogs
Fight Aging! Newsletter, July 5th 2021
In conclusion, the findings suggest that DNAm GrimAge is a strong predictor of mortality independent of genetic influences.
Heart Failure Correlates with Increased Cancer Risk
https://www.fightaging.org/archives/2021/07/heart-failure-correlates-with-increased-cancer-risk/
Age-related disease results from the underlying cell and tissue damage that causes aging. Different people accumulate that damage at modestly different rates, the result of lifestyle choices and exposure to infectious disease. Thus the presence of a sufficient burden of damage to produce one age-related disease will be accompanied by a...
Source: Fight Aging! - July 4, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Calorie Restriction Reduces the Number of Senescent T Cells in Older Mice
A sizable enough fraction of T cells of the adaptive immune system become senescent in old age to cause major issues. Senescent cells cease replication and secrete a mix of signals that cause harm in numerous different ways: rousing chronic inflammation; disrupting tissue maintenance and structure; encouraging other cells to become senescent. The cell dynamics of the immune system are quite different from those of tissues. Immune cells are provoked into replication by signals of damage or infection, and enough of that sort of stress over time will have large effects on the number of senescent immune cells.
Somatic c...
Source: Fight Aging! - June 28, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
In wake of hurricanes, every CIO should revisit their HIE
In a medical crisis, clinicians need to know people ’s medications, allergies, and medical histories to safely care for patients in shelters and to manage transfers between care settings. (Source: Healthcare IT News Blog)
Source: Healthcare IT News Blog - June 15, 2021 Category: Information Technology Tags: Interoperability, Core Technologies, Quality Care Source Type: blogs
Fight Aging! Newsletter, June 7th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 6, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
CD4 / CD8 T Cell Ratio as a Measure of Immune Aging
The state of the aged adaptive immune system can be assessed in a practical way in animal studies, such as via exposure to influenza or other well-calibrated infectious disease. This assessment is also carried out on the human population as a whole in every influenza season, but for individual humans one wants a metric that is a little less do or die. The adaptive immune system is made up of many different subtypes of B cell and T cell, each serving a different purpose. While the overall population of T cells remains fairly consistent with age, the size of different T cell subtype populations changes in characteristic ways...
Source: Fight Aging! - June 4, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
U.S. Science Embrace of Wuhan “Gain-Of-Function” Viral Research Proved A Slippery Slope
By MIKE MAGEE
The truth hurts.
Eighteen months into a disaster that has claimed 3.5 million lives around the globe, the truth is seeping out. Human error likely caused the Covid pandemic, and America’s Medical-Industrial Complex was right in the middle of it.
Signs of a “great awakening” have emerged from various corners in the month of May.
On May 14, UNC’s top virologist, Ralph Baric, who worked closely with Wuhan chief virologist and batwoman extraordinare, Shi Zhengli, signed on with 17 other scientists to a Science editorial that demanded a reexamination of Covid’s causality writing “theorie...
Source: The Health Care Blog - June 4, 2021 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Health Policy Mike Magee Wuhan Source Type: blogs
Webinar for Postdoctoral Research Associate Training (PRAT) Program Applicants
We’re hosting a webinar for students and fellows interested in the Postdoctoral Research Associate Training (PRAT) program for the October 4, 2021, receipt date:
Tuesday, June 22, 2:00-3:00 p.m. ET
PRAT is a competitive 3-year fellowship program that prepares trainees for leadership positions in biomedical careers. Training includes a mentored laboratory research experience and intensive career and leadership development activities. PRAT fellows conduct research in laboratories in the NIH Intramural Research Program (IRP) in basic biomedical research areas within the NIGMS mission. These areas include, but ar...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - June 1, 2021 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Funding Opportunities Meetings/Events Training/Fellowships/Career Development PRAT Preparing an Application Webinars Source Type: blogs
Fight Aging! Newsletter, May 31st 2021
In conclusion, iMSC-sEVs could rejuvenate the senescence of NPCs and attenuate the development of IVDD.
Cell Signaling via Exosomes in the Development of Vascular Calcification
https://www.fightaging.org/archives/2021/05/cell-signaling-via-exosomes-in-the-development-of-vascular-calcification/
Vascular calcification is a feature of aging, a process in which cells in the blood vessel wall take on inappropriate identities and activities that are more appropriate to bone tissue. Evidence of recent years implicates chronic inflammation and the presence of senescent cells in this process. Senescent cells cau...
Source: Fight Aging! - May 30, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeting Senescent Cells to Reverse the Aging of the Kidneys
Senescent cells accumulate with age and cause a wide range of pathologies. They contribute in some way to near all of the common, ultimately fatal age-related conditions. Senescent cells secrete a mix of signals that produces chronic inflammation, disrupts tissue maintenance to encourage fibrosis, and changes the behavior of other cells for the worse in numerous ways. It is the signaling that allows the comparatively small fraction of senescent cells in any given aged tissue to cause such widespread harm.
Destroying senescent cells in a targeted fashion via the use of senolytic therapies has shown great promise in a...
Source: Fight Aging! - May 28, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Best Technologies Against Food Allergies
Food has a significant role in our lives, yet, we practically have no idea what we eat. With the advent of industrial farming and the food processing industry, consumer control over food has been lost – and we lost track of substances. Food labels are far from providing enough information about what is actually in the package. Although labelling of allergens is mandatory in most countries, factual data is often hidden behind mysterious E-s and numbers. Various tech devices promise a solution.
And a solution is indeed needed. About 7.5% of the global population is allergic to certain foods. Over 200,000 people require ...
Source: The Medical Futurist - May 27, 2021 Category: Information Technology Authors: Judit Kuszkó Tags: Lifestyle medicine Artificial Intelligence in Medicine Biotechnology Digital Health Research Future of Food Health Sensors & Trackers Portable Medical Diagnostics digital technology food allergy Nima food sensor digital health techno Source Type: blogs
A Popular Science View of the State of Research into Young Blood versus Old Blood
Research spawned by heterochronic parabiosis studies, in which an old and a young animal have their circulatory systems linked, continues to provide surprises. There is considerable debate over whether helpful factors in young blood versus a dilution of harmful factors in old blood provide the majority of the benefits to the older animal, with the evidence favoring the latter at the present time. Dilution of blood plasma has been shown to produce benefits in animal studies, but that involves adding albumin to avoid diluting that essential protein. Researchers recently showed that adding recombinant albumin, and skipping th...
Source: Fight Aging! - May 24, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
