Targeting the Gut Microbiome to Treat Aging
The distribution of microbial populations making up the gut microbiome changes with age in ways that are harmful to health, causing a reduction in production of beneficial metabolites and an increase in chronic inflammation. Animal studies make it clear that some approaches to restoring a more youthful gut microbiome, such as fecal microbiota transplantation from young donors, can produce a sustained rejuvenation of the gut microbiome and consequent improvement in later life health. Given the comparatively simplicity of this approach, and that the state of the gut microbiome can accurately measured via low-cost assays, thi...
Source: Fight Aging! - October 3, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, October 3rd 2022
In conclusion, based on the analysis of proteomics and transcriptome, we identified four SRMs that may affect aging and speculated their possible mechanisms, which provides a new target for preventing aging, especially skin aging. A Popular Science Article on the State of Epigenetic Clocks https://www.fightaging.org/archives/2022/09/a-popular-science-article-on-the-state-of-epigenetic-clocks/ This popular science article is a good view of the present state of development and use of epigenetic clocks, covering the issues as well as the promise. Epigenetic age can be measured, with many different clocks...
Source: Fight Aging! - October 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Cellular Senescence Contributes to Lung Aging
Senescent cells accumulate in tissues throughout the body with age, the lung included, as noted here. This accumulation is thought to be largely the result of the progressive failure of the immune system to destroy newly created senescent cells in a timely fashion. These cells secrete a mix of signals that disrupts tissue structure and function, provoking chronic inflammation. Senolytic therapies capable of selectively destroying senescent cells have shown considerable promise in animal studies, reversing many aspects of aging and age-related disease. Senescent cells actively maintain a degraded state of tissue, and gettin...
Source: Fight Aging! - September 28, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Weekly Australian Health IT Links – 26 September, 2022.
Here are a few I have come across the last week or so. Note: Each link is followed by a title and a few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.General Comment-----I have to say the first article calls into question just how the Feds have been procuring IT and what implications there are for Federal Digital Health – a worry!Otherwise a few other good ones as well!-----https://itwire.com/government-tech-news/government-tech-policy/audit-office-releases-scathing-report-on-dta-s-ignoring-of-p...
Source: Australian Health Information Technology - September 26, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Fight Aging! Newsletter, September 26th 2022
This study examined the dose-response association between daily step count and intensity and incidence of all-cause dementia among adults in the UK. This was a UK Biobank prospective population-based cohort study (February 2013 to December 2015) with 6.9 years of follow-up (data analysis conducted May 2022). A total of 78,430 of 103,684 eligible adults aged 40 to 79 years with valid wrist accelerometer data were included. Registry-based dementia was ascertained through October 2021. We found no minimal threshold for the beneficial association of step counts with incident dementia. Our findings suggest that approxima...
Source: Fight Aging! - September 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Antigen Presenting Cells Donate Telomeres to T Cells to Increase their Longevity
T cells replicate aggressively in response to infection and other threats, yet these cells must also persist in the body for years in order to maintain immunological memory. Telomeres, repeated DNA sequences at the ends of chromosomes, shorten with each cell division. This mechanism forms a part of the Hayflick limit on somatic cell replication. When telomeres become too short, cells become senescent and self-destruct, or are destroyed by immune cells. T cells can employ telomerase to lengthen telomeres, but not to any great degree. So how do they manage such long lives in an environment of repeated threats by pathogens, a...
Source: Fight Aging! - September 22, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Career Conversations: Q & A with Bioengineer C ésar de la Fuente
Dr. César de la Fuente. Credit: Martí E. Berenguer. “Science provides adventure and excitement every single day. When you’re pushing boundaries, you get to jump into the abyss of new areas. It can be scary, but it’s an incredible opportunity to try to improve our world and people’s lives,” says César de la Fuente, Ph.D., a Presidential Assistant Professor in the Perelman School of Medicine and School of Engineering and Applied Science at the University of Pennsylvania, Philadelphia. Our interview with Dr. de la Fuente highlights his journey of becoming a scientist and his research using artificial intelligen...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - September 21, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Bacteria Computational Biology Drug Resistance Medicines Profiles Source Type: blogs

Why mandating boosters for college kids is a no good, very bad, dumb idea 
This study reinforced prior research that measured these responses up to 12 months. The stimulation of an immune response after a mild infection can even be demonstrated in the absence of actual seroconversion (detectable prior infection by antibodies) at the level of T-cells. The presence of effective immune memory, both humoral (antibody) and cellular components, after even a mild SARS-CoV-2 infection is no longer a matter of debate. One might be tempted to argue that repeated boosting can permanently suppress infection. Unfortunately, all available evidence suggests that this increased protection from infection is ...
Source: The Health Care Blog - September 14, 2022 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Health Policy Anish Koka COVID-19 vaccine Viral Myalgia Source Type: blogs

A nut allergy nightmare at 35,000 feet [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! “People developing anaphylaxis will not always have five extra minutes to spare. I do appreciate that auto-injectors are expensive, but it is not at all expensive to have an ampule or vial of epinephrine on board, which can be drawn up in five seconds. Read more… A nut allergy nightmare at 35,000 feet [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 13, 2022 Category: General Medicine Authors: Tags: Podcast Allergies & Immunology Source Type: blogs

Sepsis Sleuths
Sometimes we can be our own worst enemies without even realizing it. One devastating example is sepsis: our body’s overwhelming or impaired immune response to an insult—usually an infection or an injury to the body. According to the Centers for Disease Control and Prevention (CDC), sepsis affects at least 1.7 million people in the United States each year, and it can lead to tissue damage, organ failure, and death. (See our sepsis fact sheet for more information.) Credit: CDC. Sepsis is complex and not well-understood, so it’s challenging to diagnose and treat. NIGMS, along with its other NIH and Department o...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - September 13, 2022 Category: Research Authors: Chrissa Chverchko Tags: Tools and Techniques Computational Biology Research Roundup Sepsis Source Type: blogs

Commentators and Journalists Weigh In On Digital Health And Related Privacy, Safety, Social Media And Security Matters. Lots Of Interesting Perspectives - September 13, 2022.
-----This weekly blog is to explore the news around the larger issues around Digital Health, data security, data privacy, AI / ML. technology, social media and any related matters.I will also try to highlightADHA Propagandawhen I come upon it.Just so we keep count, the latest Notes from the ADHA Board were dated 6 December, 2018 and we have seen none since! It ’s pretty sad!Note: Appearance here is not to suggest I see any credibility or value in what follows. I will leave it to the reader to decide what is worthwhile and what is not! The point is to let people know what is being said / published that I have come upon, a...
Source: Australian Health Information Technology - September 13, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Do we need to temper our expectations of Paxlovid?
The twice-vaxxed, twice-boosted First Lady, Dr. Jill Biden, tested negative for COVID after taking Paxlovid. And then she rebounded, just like her husband did weeks ago or like Director of the National Institute of Allergy and Infectious Diseases (NIAID) and Chief Medical Advisor to the president Anthony Fauci did in June or like the 1 Read more… Do we need to temper our expectations of Paxlovid? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 10, 2022 Category: General Medicine Authors: Tags: Meds COVID Infectious Disease Source Type: blogs

5 things this allergist-immunologist will never do [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! “Jumping on the recent TikTok trend of medical professionals sharing the things they would never do given their knowledge and expertise, I am sharing the five things I would never do as a board-certified allergist-immunologist.” Kara Wada is an allergist-immunologist. She shares her story and Read more… 5 things this allergist-immunologist will never do [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 7, 2022 Category: General Medicine Authors: Tags: Podcast Allergies & Immunology Source Type: blogs

“Virgin-Soil Epidemics” Covers a Multitude of Sins
BY MIKE MAGEE Epidemics don’t appear in isolation of geography, social status, race or economics. In a recent Kaiser Family Foundation article, the authors reviewed case numbers and death rates organized by race/ethnicity. It will come as no surprise that the most vulnerable populations death rate is nearly three times greater than the least vulnerable. But what may surprise you is that the population at greatest risk was neither self-identified as Black or Hispanic, but Native American. Sadly, this is not a new story, but in the analogs of American history, it has been papered over by a partially true, but inco...
Source: The Health Care Blog - August 25, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Public Health Jeffrey Ostler Mike Magee Native Americans Virgin-Soil Epidemic Source Type: blogs

Weekly Australian Health IT Links – 22 August, 2022.
Here are a few I have come across the last week or so. Note: Each link is followed by a title and a few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.General Comment-----This week we seem to have more in the way of State-Based initiatives as well as the usual rubbish info sessions from the ADHA.Also the usual from of NBN news and news of #myHR Rule 42 – which I had never heard of!-----https://www.australianageingagenda.com.au/contributors/opinion/critical-staff-shortages-affect-more-than-frontli...
Source: Australian Health Information Technology - August 22, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs