The Orphan Drug for Acanthamoeba Keratitis (ODAK) trial: PHMB (polihexanide) 0.08% and placebo versus PHMB 0.02% and propamidine 0.1
CONCLUSIONS: PHMB 0.08% monotherapy may be as effective (or at worse only eight percentage points less effective) as dual therapy with PHMB 0.02%+propamidine (a widely used therapy) with medical cure rates of >86%, when used with the Trial treatment delivery protocol, in AK populations with similar disease severity.PMID:37802392 | DOI:10.1016/j.ophtha.2023.09.031 (Source: Herpes)
Source: Herpes - October 6, 2023 Category: Infectious Diseases Authors: John K G Dart Vincenzo Papa Paolo Rama Karl Anders Knutsson Saj Ahmad Scott Hau Sara Sanchez Antonella Franch Federica Birattari Pia Leon Adriano Fasolo Ewa Mrukwa Kominek Katarzyna Jadczyk-Sorek Fiona Carley Parwez Hossain Darwin C Minassian Source Type: research
The Orphan Drug for Acanthamoeba Keratitis (ODAK) trial: PHMB (polihexanide) 0.08% and placebo versus PHMB 0.02% and propamidine 0.1
CONCLUSIONS: PHMB 0.08% monotherapy may be as effective (or at worse only eight percentage points less effective) as dual therapy with PHMB 0.02%+propamidine (a widely used therapy) with medical cure rates of >86%, when used with the Trial treatment delivery protocol, in AK populations with similar disease severity.PMID:37802392 | DOI:10.1016/j.ophtha.2023.09.031 (Source: Herpes)
Source: Herpes - October 6, 2023 Category: Infectious Diseases Authors: John K G Dart Vincenzo Papa Paolo Rama Karl Anders Knutsson Saj Ahmad Scott Hau Sara Sanchez Antonella Franch Federica Birattari Pia Leon Adriano Fasolo Ewa Mrukwa Kominek Katarzyna Jadczyk-Sorek Fiona Carley Parwez Hossain Darwin C Minassian Source Type: research
Malabaricones from the fruit of Myristica cinnamomea King as potential agents against Acanthamoeba castellanii
Acta Trop. 2023 Sep 30:107033. doi: 10.1016/j.actatropica.2023.107033. Online ahead of print.ABSTRACTAcanthamoeba castellanii is an opportunistic free-living amoeba (FLA) pathogen which can cause fatal central nervous system (CNS) infection granulomatous amoebic encephalitis (GAE) and potentially blinding ocular infection Acanthamoeba keratitis (AK). Acanthamoeba species remain a challenging protist to treat due to the unavailability of safe and effective therapeutic drugs and their ability to protect themselves in the cyst stage. Natural products and their secondary metabolites play a pivotal role in drug discovery agains...
Source: Acta Tropica - October 2, 2023 Category: Infectious Diseases Authors: Usman Ahmed Yasodha Sivasothy Khalid Mohammed Khan Naveed Ahmed Khan Siti Mariam Abdul Wahab Khalijah Awang Muhamad Aqmal Othman Ayaz Anwar Source Type: research
Seasonal and Temporal Trends of Infectious Keratitis in Northern Vietnam
In this report, we reviewed retrospectively the microbiological data of patients with a clinical diagnosis of corneal ulcer at the microbiology laboratory of Vietnam National Eye Hospital from January 1, 2010 to March 31, 2023. We observed a seasonal pattern for fungal and microsporidial keratitis, with an annual peak in November, and an inverse relationship between fungal keratitis and inclement weather. The November peak coincided with one of the major harvesting seasons in Vietnam. We also observed increasing numbers of microsporidial and Acanthamoeba keratitis cases in recent years. Knowledge of these trends are helpfu...
Source: The American Journal of Tropical Medicine and Hygiene - October 2, 2023 Category: Tropical Medicine Authors: Binh Cao Chi Hoang Viet Vu Cung Xuan Le Hoang Anh Tuan Pham Ngoc Dong Nguyen Xuan Hiep John P Whitcher Jeremy D Keenan Source Type: research
Seasonal and Temporal Trends of Infectious Keratitis in Northern Vietnam
In this report, we reviewed retrospectively the microbiological data of patients with a clinical diagnosis of corneal ulcer at the microbiology laboratory of Vietnam National Eye Hospital from January 1, 2010 to March 31, 2023. We observed a seasonal pattern for fungal and microsporidial keratitis, with an annual peak in November, and an inverse relationship between fungal keratitis and inclement weather. The November peak coincided with one of the major harvesting seasons in Vietnam. We also observed increasing numbers of microsporidial and Acanthamoeba keratitis cases in recent years. Knowledge of these trends are helpfu...
Source: Am J Trop Med Hyg - October 2, 2023 Category: Infectious Diseases Authors: Binh Cao Chi Hoang Viet Vu Cung Xuan Le Hoang Anh Tuan Pham Ngoc Dong Nguyen Xuan Hiep John P Whitcher Jeremy D Keenan Source Type: research
Malabaricones from the fruit of Myristica cinnamomea King as potential agents against Acanthamoeba castellanii
Acta Trop. 2023 Sep 30:107033. doi: 10.1016/j.actatropica.2023.107033. Online ahead of print.ABSTRACTAcanthamoeba castellanii is an opportunistic free-living amoeba (FLA) pathogen which can cause fatal central nervous system (CNS) infection granulomatous amoebic encephalitis (GAE) and potentially blinding ocular infection Acanthamoeba keratitis (AK). Acanthamoeba species remain a challenging protist to treat due to the unavailability of safe and effective therapeutic drugs and their ability to protect themselves in the cyst stage. Natural products and their secondary metabolites play a pivotal role in drug discovery agains...
Source: Acta Tropica - October 2, 2023 Category: Infectious Diseases Authors: Usman Ahmed Yasodha Sivasothy Khalid Mohammed Khan Naveed Ahmed Khan Siti Mariam Abdul Wahab Khalijah Awang Muhamad Aqmal Othman Ayaz Anwar Source Type: research
Seasonal and Temporal Trends of Infectious Keratitis in Northern Vietnam
In this report, we reviewed retrospectively the microbiological data of patients with a clinical diagnosis of corneal ulcer at the microbiology laboratory of Vietnam National Eye Hospital from January 1, 2010 to March 31, 2023. We observed a seasonal pattern for fungal and microsporidial keratitis, with an annual peak in November, and an inverse relationship between fungal keratitis and inclement weather. The November peak coincided with one of the major harvesting seasons in Vietnam. We also observed increasing numbers of microsporidial and Acanthamoeba keratitis cases in recent years. Knowledge of these trends are helpfu...
Source: The American Journal of Tropical Medicine and Hygiene - October 2, 2023 Category: Tropical Medicine Authors: Binh Cao Chi Hoang Viet Vu Cung Xuan Le Hoang Anh Tuan Pham Ngoc Dong Nguyen Xuan Hiep John P Whitcher Jeremy D Keenan Source Type: research
Seasonal and Temporal Trends of Infectious Keratitis in Northern Vietnam
In this report, we reviewed retrospectively the microbiological data of patients with a clinical diagnosis of corneal ulcer at the microbiology laboratory of Vietnam National Eye Hospital from January 1, 2010 to March 31, 2023. We observed a seasonal pattern for fungal and microsporidial keratitis, with an annual peak in November, and an inverse relationship between fungal keratitis and inclement weather. The November peak coincided with one of the major harvesting seasons in Vietnam. We also observed increasing numbers of microsporidial and Acanthamoeba keratitis cases in recent years. Knowledge of these trends are helpfu...
Source: Am J Trop Med Hyg - October 2, 2023 Category: Infectious Diseases Authors: Binh Cao Chi Hoang Viet Vu Cung Xuan Le Hoang Anh Tuan Pham Ngoc Dong Nguyen Xuan Hiep John P Whitcher Jeremy D Keenan Source Type: research
Malabaricones from the fruit of Myristica cinnamomea King as potential agents against Acanthamoeba castellanii
Acta Trop. 2023 Sep 30:107033. doi: 10.1016/j.actatropica.2023.107033. Online ahead of print.ABSTRACTAcanthamoeba castellanii is an opportunistic free-living amoeba (FLA) pathogen which can cause fatal central nervous system (CNS) infection granulomatous amoebic encephalitis (GAE) and potentially blinding ocular infection Acanthamoeba keratitis (AK). Acanthamoeba species remain a challenging protist to treat due to the unavailability of safe and effective therapeutic drugs and their ability to protect themselves in the cyst stage. Natural products and their secondary metabolites play a pivotal role in drug discovery agains...
Source: Acta Tropica - October 2, 2023 Category: Infectious Diseases Authors: Usman Ahmed Yasodha Sivasothy Khalid Mohammed Khan Naveed Ahmed Khan Siti Mariam Abdul Wahab Khalijah Awang Muhamad Aqmal Othman Ayaz Anwar Source Type: research
Seasonal and Temporal Trends of Infectious Keratitis in Northern Vietnam
In this report, we reviewed retrospectively the microbiological data of patients with a clinical diagnosis of corneal ulcer at the microbiology laboratory of Vietnam National Eye Hospital from January 1, 2010 to March 31, 2023. We observed a seasonal pattern for fungal and microsporidial keratitis, with an annual peak in November, and an inverse relationship between fungal keratitis and inclement weather. The November peak coincided with one of the major harvesting seasons in Vietnam. We also observed increasing numbers of microsporidial and Acanthamoeba keratitis cases in recent years. Knowledge of these trends are helpfu...
Source: The American Journal of Tropical Medicine and Hygiene - October 2, 2023 Category: Tropical Medicine Authors: Binh Cao Chi Hoang Viet Vu Cung Xuan Le Hoang Anh Tuan Pham Ngoc Dong Nguyen Xuan Hiep John P Whitcher Jeremy D Keenan Source Type: research
Seasonal and Temporal Trends of Infectious Keratitis in Northern Vietnam
In this report, we reviewed retrospectively the microbiological data of patients with a clinical diagnosis of corneal ulcer at the microbiology laboratory of Vietnam National Eye Hospital from January 1, 2010 to March 31, 2023. We observed a seasonal pattern for fungal and microsporidial keratitis, with an annual peak in November, and an inverse relationship between fungal keratitis and inclement weather. The November peak coincided with one of the major harvesting seasons in Vietnam. We also observed increasing numbers of microsporidial and Acanthamoeba keratitis cases in recent years. Knowledge of these trends are helpfu...
Source: Am J Trop Med Hyg - October 2, 2023 Category: Infectious Diseases Authors: Binh Cao Chi Hoang Viet Vu Cung Xuan Le Hoang Anh Tuan Pham Ngoc Dong Nguyen Xuan Hiep John P Whitcher Jeremy D Keenan Source Type: research
Seasonal and Temporal Trends of Infectious Keratitis in Northern Vietnam
In this report, we reviewed retrospectively the microbiological data of patients with a clinical diagnosis of corneal ulcer at the microbiology laboratory of Vietnam National Eye Hospital from January 1, 2010 to March 31, 2023. We observed a seasonal pattern for fungal and microsporidial keratitis, with an annual peak in November, and an inverse relationship between fungal keratitis and inclement weather. The November peak coincided with one of the major harvesting seasons in Vietnam. We also observed increasing numbers of microsporidial and Acanthamoeba keratitis cases in recent years. Knowledge of these trends are helpfu...
Source: Am J Trop Med Hyg - October 2, 2023 Category: Infectious Diseases Authors: Binh Cao Chi Hoang Viet Vu Cung Xuan Le Hoang Anh Tuan Pham Ngoc Dong Nguyen Xuan Hiep John P Whitcher Jeremy D Keenan Source Type: research
Lately Diagnosed Acanthamoeba Keratitis Manifesting as an Intrastromal Corneal Abscess: A Case Report
Eye Contact Lens. 2023 Sep 15. doi: 10.1097/ICL.0000000000001034. Online ahead of print.ABSTRACTA 42-year-old female contact lens wearer presented to a local emergency department with a 3-day history of decreased vision and ocular discomfort in her right eye. She was started on topical fluorometholone and oral acyclovir with initial diagnosis of herpes simplex keratitis. After 3 weeks of worsening symptoms, she was diagnosed with bacterial corneal ulcer and treated with levofloxacin eye drops every 2 hr. After 14 days of no improvement, she was referred to our clinic for further workup. Slitlamp examination demonstrated a ...
Source: Herpes - September 15, 2023 Category: Infectious Diseases Authors: Sepehr Feizi Zahra Karjou Hamed Esfandiari Source Type: research
Lately Diagnosed Acanthamoeba Keratitis Manifesting as an Intrastromal Corneal Abscess: A Case Report
Eye Contact Lens. 2023 Sep 15. doi: 10.1097/ICL.0000000000001034. Online ahead of print.ABSTRACTA 42-year-old female contact lens wearer presented to a local emergency department with a 3-day history of decreased vision and ocular discomfort in her right eye. She was started on topical fluorometholone and oral acyclovir with initial diagnosis of herpes simplex keratitis. After 3 weeks of worsening symptoms, she was diagnosed with bacterial corneal ulcer and treated with levofloxacin eye drops every 2 hr. After 14 days of no improvement, she was referred to our clinic for further workup. Slitlamp examination demonstrated a ...
Source: Herpes - September 15, 2023 Category: Infectious Diseases Authors: Sepehr Feizi Zahra Karjou Hamed Esfandiari Source Type: research
Comparing Cytotoxicity and Efficacy of Miltefosine and Standard Antimicrobial Agents Against Acanthamoeba Trophozoites and Cyst Forms: An In Vitro Study
Acta Trop. 2023 Aug 27:107009. doi: 10.1016/j.actatropica.2023.107009. Online ahead of print.ABSTRACTAcanthamoeba keratitis (AK) is an eye disease often occurring in contact lens wearers. AK treatment is prolonged and requires multiple drugs, which can lead to adverse effects. Our study aimed to compare the in vitro activities and safety of Miltefosine with that of conventional antimicrobial agents used to treat AK. Acanthamoeba castellanii genotype T4 was obtained from a patient with keratitis and subjected to in vitro susceptibility testing with various antimicrobial agents, including Chlorhexidine, Pentamidine isethiona...
Source: Acta Tropica - August 29, 2023 Category: Infectious Diseases Authors: Alireza Latifi Mehdi Mohebali Setayesh Yasami Mohammad Soleimani Mostafa Rezaian Elham Kazemirad Source Type: research
