The Orphan Drug for Acanthamoeba Keratitis (ODAK) trial: PHMB (polihexanide) 0.08% and placebo versus PHMB 0.02% and propamidine 0.1

CONCLUSIONS: PHMB 0.08% monotherapy may be as effective (or at worse only eight percentage points less effective) as dual therapy with PHMB 0.02%+propamidine (a widely used therapy) with medical cure rates of >86%, when used with the Trial treatment delivery protocol, in AK populations with similar disease severity.PMID:37802392 | DOI:10.1016/j.ophtha.2023.09.031

Source: Herpes - October 6, 2023 Category: Infectious Diseases Authors: John K G Dart Vincenzo Papa Paolo Rama Karl Anders Knutsson Saj Ahmad Scott Hau Sara Sanchez Antonella Franch Federica Birattari Pia Leon Adriano Fasolo Ewa Mrukwa Kominek Katarzyna Jadczyk-Sorek Fiona Carley Parwez Hossain Darwin C Minassian Source Type: research