Neuroinflammation and Microglial Activation at Rostral Ventrolateral Medulla Underpin Cadmium-Induced Cardiovascular Dysregulation in Rats

CONCLUSION: Based on these biochemical, pharmacological and morphological observations, we conclude that neuroinflammation and microglial activation at RVLM, and their downstream cellular mechanisms, causally underpin cadmium-induced cardiovascular dysregulation.PMID:34408468 | PMC:PMC8364915 | DOI:10.2147/JIR.S325528
Source: Cell Research - Category: Cytology Authors: Source Type: research

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AbstractGeneral anesthesia is a reversible drug-induced state of altered arousal characterized by loss of responsiveness due to brainstem inactivation. Precise identification of the moment in which responsiveness is lost during the induction of general anesthesia is extremely important to provide information regarding an individual ’s anesthetic requirements and help intraoperative drug titration. To characterize the transition from responsiveness to unresponsiveness more objectively, we studied neurophysiologic-derived parameters of electromyographic records of electrically evoked blink reflex as a means of identify...
Source: Journal of Clinical Monitoring and Computing - Category: Information Technology Source Type: research
CONCLUSION: This anatomical study presents an ultrasound-guided subplatysmal SCA block to optimize, in addition to a cervical plexus block, the quality of anesthesia for carotid endarterectomies.PMID:34675651 | PMC:PMC8520968 | DOI:10.2147/LRA.S328987
Source: Local and Regional Anesthesia - Category: Anesthesiology Authors: Source Type: research
CONCLUSIONS: These findings suggest that there might be an alteration in the modulation of the sympathetic and parasympathetic nervous systems, which apparently augments sympathetic tone and decreases parasympathetic tone. Population norms should be studied and published for COVID-19 patients over short-term and 24-h HRV measurements.PMID:34674515 | DOI:10.4097/kja.21338
Source: Korean Journal of Anesthesiology - Category: Anesthesiology Authors: Source Type: research
Heart rate (HR) and blood pressure as well as adverse cardiovascular events show clear circadian patterns, which are linked to interdependent daily variations in physical activity and cardiac autonomic nerve system (ANS) activity. We set out to assess the relative contributions of the ANS (alone) and physical activity to circadian HR fluctuations. To do so, we measured HR (beats per minute, bpm) in mice that were either immobilized using isoflurane anesthesia or free-moving. Nonlinear fits of HR data to sine functions revealed that anesthetized mice display brisk circadian HR fluctuations with amplitudes of 47.1±7.4...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
BACKGROUND The cough reflex or aspiration under monitored anaesthesia care might be associated with sedative-induced changes in swallowing and intra-oral water-retaining abilities. OBJECTIVES To investigate the effects of moderate propofol sedation on swallowing and intra-oral water-retaining ability. DESIGN Prospective observational study. SETTING Single tertiary care centre during 2017. PARTICIPANTS A total of 13 healthy adult volunteers. INTERVENTION Volunteers in the supine position were asked to retain 10 ml of orally injected water for 5 min. After 5 minutes or when the wate...
Source: European Journal of Anaesthesiology - Category: Anesthesiology Tags: Anaesthesia Source Type: research
Anesthesiol Res Pract. 2021 Oct 4;2021:9243945. doi: 10.1155/2021/9243945. eCollection 2021.ABSTRACTOlder patients undergoing hip fracture surgery often experience intraoperative hemodynamic instability despite maintaining cardiac function. Although preoperative hemodynamics in such patients have been demonstrated mainly through invasive monitoring, few studies have addressed hemodynamics based on noninvasively measured parameters. We aimed to investigate preoperative hemodynamic states in older hip fracture patients using transthoracic echocardiography (TTE). The TTE data of patients aged>75 years who underwent hip fra...
Source: Anesthesiology Research and Practice - Category: Anesthesiology Authors: Source Type: research
Conclusion: Dexmedetomidine ranged from 0.25 to 1 mg/kg could improve the anesthesia quality and decreased the neuronal hyperactivities and the overactive behaviors when combined with Esk. However, Dex dose-dependently increased the recovery time from anesthesia. It demonstrated that a small dose of Dex 0.25 mg/kg could be sufficient to attenuate Esk-induced psychotomimetic side effects without extension of recovery time in Kunming mice.
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
This report confirms how the use of NIV can support alveolar ventilation, before, during and after mini-invasive procedures, and prevent respiratory complications.PMID:34632296 | PMC:PMC8489166 | DOI:10.36185/2532-1900-055
Source: Acta Myologica - Category: Neurology Authors: Source Type: research
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