Dietary Phytochemicals in Cancer Signalling Pathways: Role of miRNA targeting

Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210420101605. Online ahead of print.ABSTRACTCancer is a multi-factorial health condition involving uncontrolled cell divisions. The disease has its roots in genetic mutation. This disease affects men, women, and even children. Chemotherapy, photodynamic, photothermal, and hormonal therapies have been used to treat this deadliest disease but a huge percentage of patients have chances of disease recurrence or resistance. Nowadays dysregulation in miRNAs is considered one of the key factors for the development and progression of different types of cancers as they control the expression of genes responsible for cell proliferation, growth, differentiation, and apoptosis. Dietary phytochemicals with anticancer properties have been gaining focus for cancer treatment since they are found more effective in targeting cancer via regulating miRNAs expression. These phytochemicals have no side effects and are readily available at a low cost. Several dietary phytochemicals with regulatory effects on the expression of miRNAs have been reported and include curcumin, diallyl disulphide, 3, 30-diindolylmethane, ellagic acid, genistein, indole-3-carbinol, quercetin, resveratrol, and sulforaphane. They exert their regulatory effects against different types of cancer either by upregulating or downregulating different cancer signalling pathways and inhibit its progression. Curcumin down-regulates SHH pathways, epigallocatechin-3-gallate regulat...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Source Type: research