Secondary prevention of variceal bleeding in adults with previous oesophageal variceal bleeding due to decompensated liver cirrhosis: a network meta-analysis

CONCLUSIONS: The evidence indicates considerable uncertainty about the effect of the interventions on mortality. Variceal band ligation might result in fewer serious adverse events than sclerotherapy. TIPS might result in a large decrease in symptomatic rebleed than variceal band ligation. Sclerotherapy probably results in fewer 'any' variceal rebleeding than no active intervention. Beta-blockers plus sclerotherapy and TIPS probably result in fewer 'any' variceal rebleeding than sclerotherapy. Beta-blockers alone and TIPS might result in more other compensation events than sclerotherapy. The evidence indicates considerable uncertainty about the effect of the interventions in the remaining comparisons. Accordingly, high-quality randomised comparative clinical trials are needed.PMID:33784794 | DOI:10.1002/14651858.CD013122.pub2

Source: Cochrane Database of Systematic Reviews - March 30, 2021 Category: General Medicine Authors: Maria Corina Plaz Torres Lawrence Mj Best Suzanne C Freeman Danielle Roberts Nicola J Cooper Alex J Sutton Davide Roccarina Amine Benmassaoud Laura Iogna Prat Norman R Williams Mario Csenar Dominic Fritche Tanjia Begum Sivapatham Arunan Maxine Tapp Elisab Source Type: research