Comparative analysis of the effects of long term 3,5-T2 treatment on the murine hepatic proteome and transcriptome under conditions of normal diet and high fat diet

CONCLUSION: While confirming the beneficial hepatic liver fat reduction by 3,5-T2 treatment, our data suggest that besides the well-known induction of fatty acid oxidation the stimulation of cholesterol- and bile acid synthesis with subsequent excretion of the latter via bile might represent a further important mechanism in this context. The obvious intensified male sex steroid exposition of the liver in 3,5-T2-treated HFD animals can be predicted to cause enhanced hepatic "masculinization", with not yet clear but potentially detrimental physiological consequences.PMID:33637021 | DOI:10.1089/thy.2020.0160

Source: Thyroid : official journal of the American Thyroid Association - February 27, 2021 Category: Endocrinology Authors: Julika Lietzow Janine Golchert Maik Pietzner Uwe V ölker Matti Poutanen Claes Ohlsson Georg Homuth Josef K öhrle Source Type: research