Neurodegenerative diseases and Flavonoids: Special reference to kaempferol.

Neurodegenerative diseases and Flavonoids: Special reference to kaempferol.
CNS Neurol Disord Drug Targets. 2021 Jan 29;:
Authors: Rahul, Siddique YH
Abstract
Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, Huntington's disease, Multiple Sclerosis and Ischemic stroke have become a major health problem worldwide. Pre-clinical studies have demonstrated the beneficial effects of flavonoids on neurodegenerative diseases and suggesting them to be used as therapeutic agents. Kaempferol is found in many plants such as tea, beans, broccoli,strawberriesand has neuroprotective effects against the development of many neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease and Huntington's disease. The present study summarizesthe neuroprotective effects of kaempferol in various models of neurodegenerative diseases. Kaempferol delays the initiation as well as the progression of neurodegenerative disorders by acting as a scavenger of free radicals and preserving the activity of various antioxidant enzymes. Kaempferolcan crossthe blood-brain barrier (BBB), and therefore results inan enhanced protective effect. The multi-target property of kaempferol makes it a potential dietary supplement in preventing and treating neurodegenerative diseases.
PMID: 33511932 [PubMed - as supplied by publisher]

Source: CNS and Neurological Disorders Drug Targets - January 29, 2021 Category: Drugs & Pharmacology Authors: Rahul, Siddique YH Tags: CNS Neurol Disord Drug Targets Source Type: research