PNPLA3 gene polymorphism is associated with liver steatosis in children with Down syndrome
We, previously, demonstrated that children with Down syndrome (DS) exhibited a greater risk of steatosis than the general pediatric population. This trend is independent of obese phenotype, thus suggesting a role of genetic predisposition. Therefore, we investigated the prevalence of non-alcoholic fatty liver disease and metabolic syndrome (MetS) in function of genetic susceptibility and adipocytokine levels in children with DS.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Diletta Valentini, Antonella Mosca, Chiara Di Camillo, Annalisa Crudele, Maria Rita Sartorelli, Vittorio Scoppola, Luigi Tarani, Alberto Villani, Massimiliano Raponi, Antonio Novelli, Anna Alisi Source Type: research
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