Elucidating the role of excision repair cross-complement group 1 in oral epithelial dysplasia and early invasive squamous cell carcinoma: An immunohistochemical study

Conclusion: Disruption in the mechanisms that regulate cell cycle checkpoints and DNA repair mechanism results in genomic instability; these alterations might contribute to carcinoma. ERCC1 is essential to repair the DNA damage induced by various carcinogens. The present study shows significant difference in the expression of ERCC1 between EISCC and OED, which suggests ERCC1 could be used as one of the predictive markers.

Source: Journal of Oral and Maxillofacial Pathology - May 7, 2020 Category: ENT & OMF Authors: Spoorti Kulkarni Monica Solomon Deepthi Pankaj Sunitha Carnelio Chetana Chandrashekar Nisha Shetty Source Type: research