Stem Cells in Tumour Microenvironment Aids for Prolonged Survival Rate of Cancer Cells and Developed Drug Resistance: Major Challenge in Osteosarcoma Treatment.

Stem Cells in Tumour Microenvironment Aids for Prolonged Survival Rate of Cancer Cells and Developed Drug Resistance: Major Challenge in Osteosarcoma Treatment. Curr Drug Metab. 2020 Feb 14;: Authors: Birru B, Durthi CP, Kacham S, Pola M, Rajulapati SB, Parcha SR, Kamal MA Abstract Osteosarcoma is an aggressive bone cancer found in children and adolescents. The surgical removal of tumour and chemotherapy combined treatment for osteosarcoma has been widely accepted approach. However, the drug resistance developed by tumour cells resulted in recurrence of cancer. It is imperative to understand the molecular mechanism involved in the development of drug resistance and tumour progression for developing potential therapy. Tumour microenvironment and cellular cross talk via activation of various signalling pathways are responsible for tumour progression and metastasis. The comprehend reviews already available on the tumour microenvironment, signalling cascades responsible in tumour progression, and cellular crosstalk between malignant cells and immune cells. We intend to review on postulating the importance of mesenchymal stem cells (MSCs) in osteosarcoma progression and metastasis. This paper orchestrated to provide information sequentially: tumour microenvironment, MSCs role in osteosarcoma progression, hypoxic environment in MSCs recruitment at the tumour site and importance of exosomes in tumorigenesis, progression and metastasis. Over...
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research