Improved Mitochondrial Metabolism and Reduced Inflammation Following Attenuation of Murine Lupus With Coenzyme Q10 Analog Idebenone

ConclusionIdebenone ameliorates murine lupus disease activity and the severity of organ damage, supporting the hypothesis that agents that modulate mitochondrial biologic processes may have a therapeutic role in human SLE.

Source: Arthritis and Rheumatology - January 26, 2020 Category: Rheumatology Authors: Luz P. Blanco, Hege L. Pedersen, Xinghao Wang, Ya íma L. Lightfoot, Nickie Seto, Carmelo Carmona‐Rivera, Zu‐Xi Yu, Victoria Hoffmann, Peter S. T. Yuen, Mariana J. Kaplan Tags: Original Article Source Type: research