Antiobesity and hypolipidemic effects of protease A-digested crude-chalaza hydrolysates in a high-fat diet

Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Jr-Wei Chen, Yi-Ling Lin, Chung-Hsi Chou, Yi-Hsieng Samuel Wu, Sheng-Yao Wang, Yi-Chen ChenAbstractA high-fat diet is a major risk factor for obesity and heart failure. Our previous study has demonstrated that protease A-digested crude-chalaza hydrolysates (CCH-As) with a specific free amino-acid and carnosine/anserine profile show lipid-lowering and antioxidant activities against chronic alcohol consumption. The antiobesity and hypolipidemic effects of our CCH-As against a high-fat diet was to investigated in this study. In high-fat-diet fed hamsters, supplementing CCH-As reduced liver/perirenal-adipose-tissue sizes, and serum triglyceride, LDLC/HDLC, and TBARS values (p < 0.05). Supplementing CCH-As increased lipolysis (hormone sensitive lipase, carnitine palmitoyltransferase 1, and uncoupling protein 2) in the perirenal-adipose tissues of high-fat-diet fed hamsters (p < 0.05); meanwhile decreased cholesterol biosynthesis (squalene synthase), and upregulated bile-acid biosynthesis (cholesterol 7 alpha-hydroxylase) and cholesterol clearance ability (low-density lipoprotein receptor) in livers (p < 0.05). Daily fecal lipid and bile-acid outputs were also increased in high-fat-diet fed hamsters cotreated with CCH-As. Therefore, this CCH-A can be characterized as an antiobesity and cardioprotective ingredient.Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research