When pregnant moms are stressed out, babies' brains suffer

(Children's National Hospital) Knowing that your unborn fetus has congenital heart disease causes such pronounced maternal stress, anxiety and depression that these women's fetuses end up with impaired development in key brain regions before they are born, according to research published online Jan. 13, 2020, in JAMA Pediatrics.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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Contributors : Alexander B Niculescu ; Helen Le-NiculescuSeries Type : Expression profiling by arrayOrganism : Homo sapiensShort-memory dysfunction is a key early feature of Alzheimer Disease. Psychiatric patients may be at higher risk for memory dysfunction and subsequent Alzheimer due to the negative effects of stress and depression on the brain. We carried out longitudinal within-subject studies in male and female psychiatric patients to identify blood gene expression biomarkers that track short term memory as measured by the retention measure in the Hopkins Verbal Learning Test. These biomarkers were prioritized with a...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Conclusion: Here, we reveal several Nrf2 dose-responsive miRNA loci harboring putative upstream antioxidant response elements (AREs). Intriguingly, Nrf2-mediated miRNA responses were distinctly enriched for post-transcriptional regulation of cardiac-specific mRNAs. Altogether, these data reveal Nrf2 as a potent regulator of cardiac miRNA expression and provide novel candidates for future mechanistic investigation into the relationship between myocardial redox status and pathophysiology.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Mus musculus Source Type: research
Conclusion: Here, we reveal several Nrf2 dose-responsive miRNA loci harboring putative upstream antioxidant response elements (AREs). Intriguingly, Nrf2-mediated miRNA responses were distinctly enriched for post-transcriptional regulation of cardiac-specific mRNAs. Altogether, these data reveal Nrf2 as a potent regulator of cardiac miRNA expression and provide novel candidates for future mechanistic investigation into the relationship between myocardial redox status and pathophysiology.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Lucas C Pantaleao ; Susan E Ozanne ; Ania WilczynskaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity during pregnancy is associated with fetal growth restriction in the offspring. We used RNA next generation sequencing analysis (HiSeq2000) to have a snapshot of the placenta transcriptome at embryonic day 19 to examine whether mice exposed to maternal obesity had significant changes in their transcriptome which may lead to growth restriction in the fetus.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Publication date: Available online 31 March 2020Source: Life SciencesAuthor(s): Mohsen Enayati, Belal Mosaferi, Judith R. Homberg, Danielle Mendes Diniz, Ali-Akbar Salari
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 29 March 2020Source: Clinical Epidemiology and Global HealthAuthor(s): Souheil Hallit, Chadia Haddad, Rabih Hallit, Marwan Akel, Sahar Obeid, Georges Haddad, Michel Soufia, Wael Khansa, Rony Khoury, Nelly Kheir, Christiane Abi Elias Hallit, Pascale Salameh
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
Hi everyone, I just made this account but I've been active on this forum for over 8 years. I withdrew from med during 3rd semester due to anxiety (W's for that semester but ~B average for med school overall). While in med school I saw friends fail things like Step 1, Step 2 CS, or not match and have to SOAP. In med school I had trouble sleeping occasionally. Then during my 3rd semester the trouble sleeping became severe anxiety as I kept having unwanted thoughts of not matching. I think... Help a med school dropout
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Clinicians [ RN / NP / PA ] Source Type: forums
We present a case of severe pulmonary hypertension in the setting of perimembranous VSD and severe AS.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (24) Source Type: research
Health literacy is an established concept in the health care world that seeks to understand people's comprehension of various healthcare information and their ability to apply it. Health literacy has been extensively studied in the heart failure literature, and inadequate health literacy has been linked to impaired ability to assess risk versus benefit information, poorer physical and mental health, increased hospitalizations, and an inability to fully engage in treatment planning and self-care.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (74) Source Type: research
By Susan Blumenthal, M.D. and Alexandrea Adams The recent commemoration of National Women’s Health Week provided an important time to mark the progress that has been made in advancing women’s health over the past two decades and to highlight what more needs to be done to achieve women’s health equity in America. Historically, women have experienced discrimination in health care despite making 80 percent of health care decisions for their families, using more medical services than men, and suffering greater disability from chronic disease. Before the mid 1990’s, women were often excluded as subjects ...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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