Dark Waters Tells the True Story of the Lawyer Who Took DuPont to Court and Won. But Rob Bilott ’s Fight Is Far From Over

Rob Bilott, a corporate lawyer-turned-environmental crusader, doesn’t much care if he’s made enemies over the years. “I’ve been dealing with this for almost three decades,” he says. “I can’t really worry about if the people on the other side like me or not.” Bilott used to be on the other side. The Todd Haynes-directed movie Dark Waters, now playing in theaters, tells the story of how the lawyer, played by Mark Ruffalo, switched allegiances. As happened in real life, the movie depicts Ruffalo’s Bilott as a lawyer who defends large chemical companies before he is approached for help in 1998 by Wilbur Tennant (Bill Camp), a West Virginia farmer whose land was contaminated by chemical giant DuPont. Inflamed by that injustice, and the complicity of local authorities, the lawyer risks his career as he embarks on a decades-long legal siege of one of America’s most powerful corporations. He works, at first, on Tennant’s behalf, then pursues a class action suit representing around 70,000 people living near a chemical plant that allegedly contaminated drinking water with PFOA, a toxic chemical used in the production of Teflon. In recent years, studies have correlated long-term exposure to PFOA with a number of illnesses, including some types of cancer. In 2017, Bilott won a $671 million settlement on behalf of more than 3,500 plaintiffs. Those people claimed they had contracted diseases, among them kidney cancer and t...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized movies onetime Source Type: news

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We describe the landscape of cyclin and interactive gene pathway alterations in 190,247 solid tumors. METHODS: Using comprehensive genomic profiling (315 genes,>500× coverage), samples were analyzed for alterations in activating/sensitizing cyclin genes (CDK4 amplification, CDK6 amplification, CCND1, CCND2, CCND3, CDKN2B [loss], CDKN2A [loss], SMARCB1), hormone genes (estrogen receptor 1 [ESR1], androgen receptor [AR]), and co-alterations in genes leading to cyclin inhibitor therapeutic resistance (RB1 and CCNE1). RESULTS: Alterations in at least one cyclin activating/sensitizing gene occurred in 24% of ...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
Purpose of review To discuss and highlight the recent findings in urological oncology focusing on nuclear medicine advances on imaging and therapy. Recent findings Testicular tumors: 18F-FDG as the standard positron emission tomography (PET) tracer with proven good accuracy in detecting metastatic testicular cancer; urothelial cancer: good accuracy of 18F-FDG PET in detecting distant metastases but poor results in detecting local disease; prostate cancer: prostate-specific membrane antigen (PSMA) is a promising target for imaging prostate cancer with unprecedented accuracy in both staging and restaging and prospective...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: PET IMAGING IN UROLOGY: Edited by Stefano Fanti and Declan G. Murphy Source Type: research
A. Calin Available systemic treatment options for cancers of the genitourinary system have experienced great progress in the last decade. However, a large proportion of patients eventually develop resistance to treatment, resulting in disease progression and shorter overall survival. Biomarkers indicating the increasing resistance to cancer therapies are yet to enter clinical routine. Long non-coding RNAs (lncRNA) are non-protein coding RNA transcripts longer than 200 nucleotides that exert multiple types of regulatory functions of all known cellular processes. Increasing evidence supports the role of lncRNAs in cance...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Conclusions: Cytoreductive nephrectomy should no longer be considered the standard of care in patients with T3b or T4, or node-positive, and metastatic rcc. Eligible patients should be treated with systemic therapy and have their primary tumour removed only after review at a multidisciplinary case conference (mcc). Adjuvant sunitinib after surgery is not recommended. Patients with venous tumour thrombus should be considered for surgical intervention. Patients with T3, T4, or node-positive utuc should have their tumour removed without delay. Decisions concerning lymph node dissection should be done at a mcc and be based on ...
Source: Current Oncology - Category: Cancer & Oncology Tags: Curr Oncol Source Type: research
ConclusionTreatment strategies for both malignancies depend on accurate clinical staging and should be integrated to provide optimal results.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
In this study, we collected a comprehensive multi-dimensional data from GWAS, gene expression, and methylation studies and generated transcriptome-wide association study (TWAS) data to further interpret the GWAS association results. We applied our previously developed method called mega-analysis of Odds Ratio (MegaOR) to prioritize CD candidate genes (CDgenes). As a result, we identified consensus sets of CDgenes (62–235 genes) based on the evidence matrix. We demonstrated that these CDgenes were significantly more frequently interact with each other than randomly expected. Functional annotation of these genes highli...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Authors: Wierzba W, Śliwczynski A, Karnafel W, Dziemidok P, Pinkas J Abstract Introduction: Many epidemiological studies show a correlation between the risk of cancer and type 2 diabetes mellitus in various populations. Material and methods: The material was obtained from the database of the National Health Fund. This publication presents a comparison of the incidence of new malignancies in rural and urban populations of diabetic patients in Poland based on the database of the National Health Fund for the period between 1.05.2008 and 30.09.2014. Results: Comparison of the mean incidence of selected maligna...
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
This study aimed to explore whether a correlation exists between the incidence and mortality of cancers and normalized internet search volumes on the big data platform, Baidu. We also assessed whether the distribution of people who searched for specific types of cancer differed by gender. Finally, we determined whether there were regional disparities among people who searched the Web for cancer-related information. Methods: Standard Boolean operators were used to choose search terms for each type of cancer. Spearman’s correlation analysis was used to explore correlations among monthly search index values for each can...
Source: Journal of Medical Internet Research - Category: General Medicine Authors: Source Type: research
Tian Zhang, M.D. Medical Oncologist at Duke University specializing in caring for patients with genitourinary cancers, including kidney, bladder, prostate, and testicular cancers, Discusses PEDIGREE T... Author: kidneycancer Added: 01/17/2019
Source: Oncology Tube - Category: Cancer & Oncology Source Type: podcasts
Tian Zhang, M.D. Medical Oncologist at Duke University specializing in caring for patients with genitourinary cancers, including kidney, bladder, prostate, and testicular cancers, Discusses Data On PE... Author: kidneycancer Added: 01/17/2019
Source: Oncology Tube - Category: Cancer & Oncology Source Type: podcasts
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