Long-term Outcomes in Down Syndrome Children After Cochlear Implantation: Particular Issues and Considerations

Objective: The aim of the study was to analyze the long-term outcomes after cochlear implantation in deaf children with Down syndrome (DS) regarding age at the first implantation and refer the results to preoperative radiological findings as well as postoperative auditory and speech performance. Additionally, the influence of the age at implantation and duration of CI use on postoperative hearing and language skills were closely analyzed in children with DS. Study Design: Retrospective analysis. Setting: Referral center (Cochlear Implant Center). Materials and Methods: Nine children with Down syndrome were compared with 220 pediatric patients without additional mental disorders or genetic mutations. Patients were divided into four categories depending on the age of the first implantation: CAT1 (0–3 yr), CAT2 (4–5 yr), CAT3 (6–7 yr), and CAT4 (8–17 yr). The auditory performance was assessed with the meaningful auditory integration scales (MAIS) and categories of auditory performance (CAP) scales. The speech and language development were further evaluated with meaningful use of speech scale (MUSS) and speech intelligibility rating (SIR). The postoperative speech skills were analyzed and compared between the study group and the reference group by using nonparametric statistical tests. Anatomic abnormalities of the inner ear were examined using magnetic resonance imaging (MRI) and high-resolution computed tomography of the temporal bones (HRCT)....
Source: Otology and Neurotology - Category: ENT & OMF Tags: COCHLEAR IMPLANTS Source Type: research

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CASE SUMMARY: A 62-year-old previously healthy man presented with left lower quadrant pain and fever. Physical examination showed left lower quadrant peritonitis. Computed tomography scan showed a pelvic abscess with extraluminal air (Fig. 1). Intravenous antibiotics were started, and CT-guided percutaneous drainage was performed. The drain was removed 1 week after discharge. One week later, he presented with dysuria and pneumaturia and was started on antibiotics. Colonoscopy confirmed diverticulosis with no other mucosal abnormalities. He underwent a successful laparoscopic sigmoidectomy with colovesical fistula takedown.
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Resident’s Corner Source Type: research
Publication date: Available online 9 December 2019Source: NeuroImageAuthor(s): Robert A. Brown, Dumitru Fetco, Robert Fratila, Giulia Fadda, Shangge Jiang, Nuha M. Alkhawajah, E. Ann Yeh, Brenda Banwell, Amit Bar-Or, Douglas L. Arnold, Canadian Pediatric Demyelinating Disease NetworkAbstractIn conventional non-quantitative magnetic resonance imaging, image contrast is consistent within images, but absolute intensity can vary arbitrarily between scans. For quantitative analysis of intensity data, images are typically normalized to a consistent reference. The most convenient reference is a tissue that is always present in th...
Source: NeuroImage - Category: Neuroscience Source Type: research
AbstractThe Parenting Stress Index (PSI) has been translated into multiple languages. The aim of the present study was to develop a Polish version of the PSI III. A total sample size of 678 parents (308 parents of children with ASD, 59 parents of children with Down syndrome, 65 parents of deaf children, 34 parents of children with other developmental disorders, and 212 parents without developmental disabilities) participated in the study. The Polish version of the PSI III was characterized by: (1) good internal consistency, (2) a three-factor structure, including Parent domain, Child domain, and the children ’s and p...
Source: Journal of Developmental and Physical Disabilities - Category: Disability Source Type: research
CONCLUSION:This study demonstrated a significant association between caries frequency and overweight/obesity in special care school children.  LIMITATIONS:Since the data was cross-sectional, causal relationships cannot be established and the observed association could be due to other unexplored factors. Because of cultural and ethical consideration, including segregation of gender in Saudi Arabia, only female children were included in the present study, which limited the findings.  
Source: Annals of Saudi Medicine - Category: General Medicine Tags: ISSUE 1 Source Type: research
Conclusions: This study identified potential relationships between maternal residential proximity to agricultural use of neurotoxic pesticides and poorer neurodevelopment in children. https://doi.org/10.1289/EHP504 Received: 08 January 2016 Revised: 13 May 2016 Accepted: 14 June 2016 Published: 25 May 2017 Address correspondence to R. Gunier, Center for Environmental Research and Childrens Health (CERCH), School of Public Health, University of California at Berkeley, 1995 University Ave., Suite 265, Berkeley, CA 94704. Telephone: (510) 847-3858. E-mail: gunier@berkeley.edu. A.B. is a volunteer member of the Board for...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
CONCLUSION: The data suggest a significant decline in the prevalence of Down syndrome; however, the prevalence of other anomalies like congenital deafness is still high.   
Source: Annals of Saudi Medicine - Category: Journals (General) Tags: ISSUE 2 Source Type: research
It is done to reinforce the inadequate sex binary and even to police non-heterosexual, queer attractions or acts“Designer babies” seems like a concept from a dystopian future, but they’re here now: would-be parents who utilize in-vitro fertilization to conceive often also have the option of genetically testing embryos and then picking which one to implant.Scientists can test for hundreds of things, from fatal genetic traits like Tay-Sachs and Huntington disease to non-fatal but culturally devalued embodiments like Down syndrome, deafness, blindness and intersex conditions. Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Genetics Childbirth Fertility problems Health & wellbeing Science Source Type: news
Being a parent is a challenge no matter what. Being a single parent, of course, requires even more responsibility and sacrifice. Being a single parent to a child facing severe intellectual disabilities, however, is a trial few among us could even imagine. Leon Borensztein, a Polish-born photographer and single father, lived this challenging tale. He began photographing his daughter, Sharon, before she was born. Now, approximately 30 years later, he's still going. Soon after Sharon's birth, Leon and his former wife could sense something wasn't right. After months of testing, the various diagnoses began to roll in: blind...
Source: Science - The Huffington Post - Category: Science Source Type: news
We report that a narrow spectrum of amino-acid substitutions within the transactivation domain of the v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog (MAF), a leucine zipper-containing transcription factor of the AP1 superfamily, profoundly affect development. Seven different de novo missense mutations involving conserved residues of the four GSK3 phosphorylation motifs were identified in eight unrelated individuals.
Source: The American Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Tags: Report Source Type: research
Jason Clark, from Barnsley, South Yorkshire, is a high-achieving 11-year-old, and his twin Aaron suffers from Down Syndrome and is deaf. Jason is raising money for his brother's education.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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