Impact of PPAR-{alpha} induction on glucose homesostasis in alcohol-fed mice

Conclusions : Our study shows that chronic alcohol consumption induces steatosis, Kuffer cell activation and hepatic insulin resistance in mice. PPAR-α agonist treatment that prevents steatosis and dampens hepatic inflammation also prevents alcohol-induced hepatic insulin resistance. However, Kupffer cell depletion little impacts on OH-induced metabolic disturbances.

Source: Clinical Science - June 12, 2013 Category: Biomedical Science Authors: V Lebrun, O Molendi-Coste, N Lanthier, C Sempoux, P D. Cani, N Van Rooijen, P Stärkel, Y Horsmans, I A Leclercq Source Type: research