Asparaginase-induced hepatotoxicity: rapid development of cholestasis and hepatic steatosis

ConclusionAsparaginase is a common cause of antineoplastic-induced liver injury with jaundice, typically with short latency, marked steatosis, and prolonged jaundice, which can lead to delays in antileukemic therapy. The cause of injury is likely direct inhibition of hepatic protein synthesis caused by asparagine depletion.
Source: Hepatology International - Category: Infectious Diseases Source Type: research