Apolipoprotein E4 Expression Causes Gain of Toxic Function in Isogenic Human Induced Pluripotent Stem Cell-Derived Endothelial Cells.

CONCLUSIONS: These cells provide novel insight into ApoE4-mediated endothelial dysfunction and provide a new platform to test potential therapies for vascular disorders.
PMID: 31315437 [PubMed - as supplied by publisher]

Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 17, 2019 Category: Cardiology Authors: Rieker C, Migliavacca E, Vaucher A, Mayer FC, Baud G, Marquis J, Charpagne A, Hegde N, Guignard L, McLachlan M, Pooler AM Tags: Arterioscler Thromb Vasc Biol Source Type: research