In recently postmenopausal women, HRT reduced a composite of death, MI, or heart failure at 10 years.

CONCLUSION In recently postmenopausal women, hormone replacement therapy reduced a composite of death, myocardial infarction, or heart failure after 10 years of therapy and an additional 6 years of follow-up.Hormone replacement therapy (HRT) vs no HRT in recently postmenopausal women†OutcomesEvent ratesAfter 10 y of therapyHRTNo HRTRRR (95% CI)NNT (CI)Death, MI, or HF‡3.2%6.5%50% (11 to 72)31 (22 to 144)At 16 yDeath, MI, or HF§6.6%11%37% (4 to 59)26 (17 to 251)†HF = heart failure; MI = myocardial infarction; other abbreviations defined in Glossary. RRR, NNT, and CI calculated from event rates and hazard ratios in article. Hazard ratio for the composite outcome was adjusted for age.‡Death (3.0% vs 5.2%, P = 0.08), MI (0.2% vs 0.8%, P = 0.21), HF (0.2% vs 1.4%, P = 0.07).§Death (5.4% vs 7.9%, P = 0.10), MI (1.0% vs 2.2%, P = 0.14), HF (0.6% vs 1.6%, P = 0.15). PMID: 23420251 [PubMed - in process]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research