Supporting your newborn ’s health: Intestinal colonization after elective cesarean section

This study confirms meta-analyses of smaller studies in the United States that suggest that cesarean section deliveries are risk factors for development of allergy and autoimmune disease. Elective cesarean section deliveries have increased from 5% in 1970 to 25% in 2010 in the US, while at the same time the incidence of autoimmune diseases has increased in Western society over the last several decades, and there may be a correlation. Altered intestinal colonization in medically-indicated vs. elective cesarean sections We have learned that major changes in intestinal colonization occur after elective cesarean sections (those done for the convenience of the patient or doctor), and not in medically-indicated cesarean sections (because of failed labor or other stress to the newborn). An expectant mother should be thoughtful about electing to do a cesarean section if vaginal delivery is an available and medically safe alternative. How can new parents manage altered colonization after an elective cesarean section to support their newborn’s developing microbiome? Colonization is affected by diet (breast milk vs. formula) and weaning to solid foods. Mothers should strongly consider breastfeeding, since breastfeeding helps establish natural colonization. Established clinical probiotics such as Lactobacillus acidophilus and Bifidobacterium infantis can be given either to lactating mothers or to newborns. A swab from a new mother’s vagina can be placed into the mouth of the...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Digestive Disorders Family Planning and Pregnancy Probiotics Women's Health Source Type: blogs

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In conclusion, compared with placebo, Brazilian propolis supplementation did not influence the risk of atopic sensitization in infants and neither did it improve nor worsen nonspecific symptoms in either mothers or their infants. PMID: 31611924 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
We report a novel pH-sensitive multi-compartmental nanoparticulate (MCP) oral delivery system that encapsulates siRNA for silencing the divalent metal transporter 1 (DMT1) gene, a primary iron transporter highly expressed in the intestine. The gelatin nanoparticles-coated with Eudragit® L100–55 are able to protect siRNA from intracellular degradation and allow for sustained release of siRNA in the cytosol. When orally-administered, Eudragit® L100–55 based MCPs containing DMT1 siRNA/gelatin NPs specifically and significantly decreased the expression of DMT1 mRNA in the duodenum, which consequently decrea...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Publication date: 15 October 2019Source: Cell Reports, Volume 29, Issue 3Author(s): Aly A. Khan, Leonid Yurkovetskiy, Kelly O’Grady, Joseph M. Pickard, Renée de Pooter, Dionysios A. Antonopoulos, Tatyana Golovkina, Alexander ChervonskySummaryEnvironmental influences (infections and diet) strongly affect a host’s microbiota. However, host genetics may influence commensal communities, as suggested by the greater similarity between the microbiomes of identical twins compared to non-identical twins. Variability of human genomes and microbiomes complicates the understanding of polymorphic mechanisms regulatin...
Source: Cell Reports - Category: Cytology Source Type: research
Chris EdwardsElizabeth Warren and Bernie Sanders continued to bash wealth in the Democratic presidential debate Tuesday night. They view wealth as a zero-sum —that people at the top essentially stole their fortunes from the rest of us. Sanderssaid, “And we cannot afford a billionaire class, whose greed and corruption has been at war with the working families of this country for 45 years.”The truth is that many of the richest people in market economies generated their fortunes by raising living standards for working families. Entrepreneurs have continuously slashed prices and improved product quality to th...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
Publication date: Available online 15 October 2019Source: Meat ScienceAuthor(s): Alexandra E. Francisco, Martin Janíček, Teresa Dentinho, Paula Portugal, João Almeida, Susana P. Alves, Letícia Fialho, Eliana Jerónimo, Rui J.B. Bessa, José Santos-SilvaAbstractThirty-two crossbred Merino branco male lambs were randomly allocated to eight diets, combining two forms of alfalfa presentation (chopped or ground), with four barley grain levels (0%, 11.2%, 21.3% and 33% dry matter (DM)), balanced by low starch agro-industrial by-products (LSBP). The diets were supplemented with 6% soybean oil and...
Source: Meat Science - Category: Food Science Source Type: research
Discussion MDSCs violently emerge in pathological conditions in an attempt to limit potentially harmful immune and inflammatory responses. Mechanisms supporting their expansion and survival are deeply investigated in cancer, in the perspective to reactivate specific antitumor responses and prevent their contribution to disease evolution. These findings will likely contribute to improve the targeting of MDSCs in anticancer immunotherapies, either alone or in combination with immune checkpoint inhibitors. New evidence indicates that the expansion of myeloid cell differentiation in pathology is subject to fine-tuning, as its...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Maunil K. Desai1 and Roberta Diaz Brinton2,3* 1School of Pharmacy, University of Southern California, Los Angeles, CA, United States 2Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States 3Departments of Pharmacology and Neurology, College of Medicine, University of Arizona, Tucson, AZ, United States Women have a higher incidence and prevalence of autoimmune diseases than men, and 85% or more patients of multiple autoimmune diseases are female. Women undergo sweeping endocrinological changes at least twice during their lifetime, puberty and menopause, with many women undergoin...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
In this study, herpes virus serological status and T cell, B cell, NK cell and monocyte populations were investigated in 251 ME/CFS patients, including 54 who were severely affected, and compared with those from 107 healthy participants and with 46 patients with Multiple Sclerosis. There were no differences in seroprevalence for six human herpes viruses between ME/CFS and healthy controls, although seroprevalence for the Epstein-Barr virus was higher in multiple sclerosis patients. Contrary to previous reports, no significant differences were observed in NK cell numbers, subtype proportions or in vitro responsiveness betwe...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractThe number of peer-reviewed articles published during the 2017 solar year and retrieved using the “autoimmunity” key word increased significantly compared to 2016 while maintaining a stable share within the immunology field, following years with alternated fortunes. A detailed arbitrary analysis of the published articles in leading immunology and autoimmunity journals provides a privileged v iewpoint on the current trends of research from both basic and clinical studies. Indeed, we are observing that major steps forward are found for rheumatoid arthritis, systemic lupus erythematosus, and systemic scler...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
AbstractRheumatoid arthritis (RA) is a chronic and progressive autoimmune disease more common in women than men (3:1). Although sex-based differences may play a complex role in promoting an autoimmune dysfunction, to date the comprehensive knowledge of the link between sex and RA is still partially lacking. Furthermore, males and females have been demonstrated to differently deal with their chronic pathologies, modifying the perceived sex-based burden of disease. Gender medicine is a newly approach focusing on the impact of gender differences on human physiology, pathophysiology, and clinical features of diseases, analyzin...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
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