Effect of Rapamycin on mesenchymal stem cells treatment for swine myocardial infarction

Conclusions: Four weeks after MSCs transplantation for curing AMI, the myocardial perfusion and glucose metabolism improved significantly in the Rapamycin group; however, the cardiac function was decreased. It is speculated that Rapamycin might have impacted the effect of MSCs transplantation in infarcted hearts. The mechanism needs further research. Index on SPECT, PET and MRI in Three GroupsControl group MSCs groupRapamycin groupP valueSRS24.43±5.4728.63±3.3420.50±7.70<0.05Defect area (cm2)41.57±12.4844.25±12.8022.50±10.74<0.05SCR12.80±4.9715.33±8.636.20±6.34<0.05Scar area (%)19.00±7.2122.67±12.799.20±9.60<0.01EDV (ml)48.96±11.5950.00±7.6160.23±11.27NSESV (ml)22.37±3.3123.09±5.6735.23±10.28<0.01EF (%)51.99±7.6454.06±8.1842.43±6.40<0.05

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Cai, M., Feng, G., Li, L., Zhang, G., Yang, X. Tags: Cardiovascular Basic Science: Metabolism and Molecular Imaging Source Type: research