Grail Presents Early Favorable CCGA Data at ASCO

Grail has been firing on all cylinders ever since it was spun-out from Illumina three years ago. From massive clinical trials to outrageous financing amounts, the liquid biopsy specialist has not let up on meeting milestones. The latest milestone from the Menlo Park, CA-based company is fairly positive data from the Circulating Cell-free Genome Atlas (CCGA) study. The massive study is a prospective, observational, longitudinal trial that has completed enrollment of about 15,000 people with and without cancer across 142 sites in the U.S. and Canada. Grail presented the results during the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting. Results from CCGA show the company’s solution detected a strong signal for 12 deadly cancer types at early stages with a very high specificity of at least 99% (or a false positive rate of 1% or less). In addition, the test identified where the cancer originated in the body (the tissue of origin) with high accuracy. The company said detection rates for the 12 deadly cancer types ranged from 59% to 86% at early stages (stages I-III). A combined analysis of this group of cancers showed robust detection at early stages (34%, 77%, and 84% at stages I, II, and III, respectively). In addition, a tissue of origin result was provided for 94% of all cancers detected and, of these, the test correctly identified the tissue of origin in 90% of cases. The 12 pre-specified cancer types included anorectal, colorectal, esophage...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news