Podcast: Immunosuppressive treatment for people with proliferative lupus nephritis

Systemic lupus erythematosus, or SLE, is an autoimmune disease that can affect any part of the body. About half the people with it develop lupus nephritis. In the June 2018 update of their Cochrane Review, David Tunnicliffe from the Centre for Kidney Research in the Children ’s Hospital at Westmead and the University of Sydney’s School of Public Health in Australia and colleagues brought together the studies that have tested a range of treatments." Lupus nephritis is a serious condition, leading to end-stage kidney disease in 15% of patients after 10 years. It mainly affects women of child-bearing age, and is more common in some groups, such as those of Hispanic and Asian ethnicity, who also experience more aggressive disease. In the 1950s, most patients survived less than five years, but newer treatments mean that more than 90% of patients will now live a normal lifespan. Cyclophosphamide-containing regimens became established as first line therapy for inducing remission in the 1970s and 1980s, but the drug has a high incidence of adverse events, such as serious infection, hair-loss, and infertility. Furthermore, response to treatment is often slow, and even if remission is achieved, the risk or relapse or flare remains considerable.In the past ten years, mycophenolate mofetil (MMF) emerged as a less toxic alternative to cyclophosphamide but there is uncertainty about which agent is more effectie. Over recent years, randomized trials have been done to compar...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news

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We present the case of a male diagnosed with a giant hepatic artery aneurysm, which first presented with pain and hemorrhage due to a partial rupture of the aneurysm. After discarding treatment with a stent or surgery due to the wide extension, we chose to embolize the hepatic artery with coils. However, the progress was unfavorable after the procedure, with the appearance of liver failure that was resolved by an urgent liver transplantation. Giant hepatic artery pseudoaneurysms are an infrequent entity and their management is a great challenge. The diagnosis is usually delayed due to non-specific clinical signs and the li...
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
CONCLUSION: Patients with certain psychosocial comorbidities had worse outcomes following liver transplantation. Further prospective and multi-center studies are warranted to properly determine guidelines for liver transplantation regarding this high-risk population. PMID: 31528246 [PubMed]
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
CONCLUSION: Autogenous bone ring procedure seemed to confer additional benefits over autologous growth factor-enriched bone graft when various parameters were compared. The sites augmented with autogenous bone ring at the end of the study period showed a sufficient gain in bone height and quality for implant placement. PMID: 31532824 [PubMed - as supplied by publisher]
Source: International Journal of Oral and Maxillofacial Implants - Category: ENT & OMF Tags: Int J Oral Maxillofac Implants Source Type: research
Publication date: Available online 18 September 2019Source: Chinese Chemical LettersAuthor(s): Zhengtong Li, Chengbing WangAbstractAccess to safe drinking water has become an extremely urgent research topic worldwide. In recent years, the technology of solar vapor generation has been extensively explored as a potential and effective strategy of transforming elements content in seawater. In this review, the basic concepts and theories of metal-based photothermal vapor generation device (PVGD) with excellent optical and thermal regulatory are introduced. In the view of optical regulation, how to achieve high-efficiency local...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
In this study, we developed a facile method to induce the La doping and cationic vacancie (VZn) on ZnO for the highly efficient complete NO oxidation. The photocatalytic NO removal efficiency increases from 36.2% to 53.6%. Most importantly, a significant suppressed NO2 production also has been realized. According to the DFT calculations, ESR spectra and in situ FTIR spectra, the introduction of La3+ induce the redistribution of charge carriers in La-ZnO, which promote the production of O2− and lead to the formation of VZn for the formation of OH, contributing to the complete oxidation of NO to nitrate. Besides, the c...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: Available online 18 September 2019Source: Chinese Chemical LettersAuthor(s): Mingfeng Ma, Long Chen, Jingzhu Zhao, Wen Liu, Haodong JiAbstractHollow microsphere structure cobalt hydroxide (h-Co(OH)2) was synthesized via an optimized solvothermal-hydrothermal process and applied to activate peroxymonosulfate (PMS) for degradation of a typical pharmaceutically active compound, ibuprofen (IBP). The material characterizations confirmed the presence of the microscale hollow spheres with thin nanosheets shell in h-Co(OH)2, and the crystalline phase was assigned to α-Co(OH)2. h-Co(OH)2 could efficiently ac...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: Available online 18 September 2019Source: Chinese Chemical LettersAuthor(s): Wenrui Cai, Renjie Xiong, Cong Mao, Meitian Xiao, Yongjun Liu, Ranjith Kumar Kankala, Xueqin ZhangAbstractTo overcome the shortcomings of single component carrier supported platinum (Pt)-based catalysts, herein, we demonstrate the fabrication of alumina combined mesoporous carbon to prepare a series of alumina-carbon composites and their corresponding Pt-based catalysts. The alumina-carbon composites Al@PhFC are synthesized by using phloroglucinol-formaldehyde resin as carbon source and aluminum acetylacetone as the aluminum sour...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: Available online 18 September 2019Source: Chinese Chemical LettersAuthor(s): Caiying Wen, Tianjiao Zhu, Xingyu Li, Huifeng Li, Xianqiang Huang, Genban SunAbstractTi3C2 belongs to MXenes family, which is a new two-dimensional material and has been applied in many fields. With simple method of hydrothermal and high temperature calcination, nanostructured Ni/Ti3C2Tx hybrid was synthesized. The stable layer structure of Ti3C2 MXene providing high surface area as well as excellent electronic conductivity are beneficial for deposition and decomposition of discharge product Li2O2. Furthermore, possessing special...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
This study presents the first case of Ir-based metal-organic cages for bio-applications in successful integration of imaging diagnosis and photodynamic therapyGraphical abstractAn Ir8Pd4-heteronuclear metal − organic cage (MOC-51) was assembled from bipodal metalloligand [Ir(ppy)2(qpy)(BF4)] with Pd(II) salt, which presents the first case of Ir-based metal-organic cages for bio-applications in successful integration of imaging diagnosis and photodynamic therapy.
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
ConclusionsThe present drug-free IVA approach may be suitable for POR patients with DOR, as it increased the number of antral follicles. The procedure also eliminated the need for 2-day incubation with drugs and required only one surgery. This approach could allow the retrieval of more oocytes in middle-age women to achieve higher pregnancy rates and deserves proper evaluation in future randomized controlled trials.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
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