Obesity: seize the day, fight the fat

Obesity is the global epidemic of the 21st century: about 1.5 billion adults worldwide are overweight, and among them, about 200 million men and 300 million women are obese [1]. In some countries, the prevalence of obesity has exceeded 50%, as in Tonga (men), and in Kuwait, Kiribati, Micronesia, Libya, Qatar, Tonga and Samoa (women) [2]. The prevalence of overweight and obesity are also increasing in children and adolescents in developed (about 25%) and in developing countries (about 13%) [2]. Obesity has been associated with many comorbidities, including type 2 diabetes mellitus (T2DM), nonalcoholic fatty liver disease (NAFLD), hypertension, chronic kidney disease, cardiovascular disease (CVD), and malignancies, leading to increased mortality observed in obese individuals [3].
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research

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ConclusionFindings highlight the importance of rethinking the way in which South Asians are labelled as a homogenous group and accounting for such differences when adapting and designing culturally-tailored DSME and or DSMS interventions in clinical practice.
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Our weekly DiabetesMine advice column addresses questions on strokes and diabetes, safe insulin storage temps and yeast infections.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
Publication date: August 2019Source: Biomedicine &Pharmacotherapy, Volume 116Author(s): Anand P. Gupta, Pragati Singh, Richa Garg, Guru R. Valicherla, Mohammed Riyazuddin, Anees A. Syed, Zakir Hossain, Jiaur R. GayenAbstractAimsTo investigate the role of pancreastatin inhibitor (PSTi8) in lipid homeostasis and insulin sensitivity in dexamethasone induced fatty liver disease associated type 2 diabetes.Main methodsGlucose releases assay, lipid O staining and ATP/AMP ratio were performed in HepG2 cells. Twenty four mice were randomly divided into 4 groups: Control group (saline), DEX (1 mg/kg, im) for 17 days, DEX+...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
ConclusionsAdministration of Momordica balsamina methanolic extract protects against some injurious haematological changes induced by hyperglycaemia, which may reduce the risks of cardiovascular complications.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: November 2019Source: Japanese Dental Science Review, Volume 55, Issue 1Author(s): Hiromitsu Kishimoto, Kazuma Noguchi, Kazuki TakaokaSummaryBisphosphonate-related osteonecrosis of the jaw (BRONJ), characterized by refractory bone exposure, has recently emerged as a serious side effect of bisphosphonate (BPs) treatment. We discuss novel insights that may help to improve the efficacy of BRONJ treatment and prevention. Our report highlights the following: (1) The presence of exposed bone in patients taking BPs does not necessarily reflect BRONJ, and diagnoses of oral ulceration with bone sequestration and ma...
Source: Japanese Dental Science Review - Category: Dentistry Source Type: research
Publication date: Available online 18 May 2019Source: Journal of Herbal MedicineAuthor(s): Richard Komakech, Youngmin KangAbstractMedicinal plants have been an integral part of the healthcare system for centuries. Prunus africana, an evergreen plant of the family Rosaceae in sub-Saharan Africa, has been used to treat numerous diseases and disorders since time immemorial. Over the past decades, several ethnomedicinal surveys were conducted in many communities across Africa which validated the use of P. africana in traditional medicine. The increased interest in P. africana across the globe has led to several pharmacological...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research
Publication date: Available online 17 May 2019Source: Brazilian Journal of Anesthesiology (English Edition)Author(s): Caio Klippel Amaral, Márcio Luiz Benevides, Marília Marquioreto Benevides, Diogo Leite Sampaio, Cor Jesus Fernandes FontesAbstractBackground and objectivesPregnant women are considered patients at risk for pulmonary aspiration of gastric contents. The study aim was to evaluate the gastric antral cross-sectional area using ultrasound.MethodIn this prospective study, 85 scheduled term pregnant women underwent gastric ultrasound. The outcomes were the measurement of the gastric antral cross-secti...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
Authors: Zeng DB, Di L, Zhang RC, Guo QL, Duan BW, Jia CY, Chen F, Lin DD, Zang YJ, Lu SC Abstract Background: Studies have demonstrated that liver fibrosis can be reversed by medication treatments. After splenectomy, cirrhosis patients have short-term changes in several serum markers for cirrhosis and liver stiffness. Aims: To investigate the effect of splenectomy on the severity of cirrhosis. Methods: A total of 62 patients with cirrhosis and portal hypertension receiving splenectomy from December 2014 to July 2017 were enrolled. The degree of cirrhosis was preoperatively and postoperatively evaluated by ...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Association between chronic kidney disease and synergistic, potentially nephrotoxic medication use in elderly hospitalized patients: A single-center cross-sectional study
. Int J Clin Pharmacol Ther. 2019 May 16;: Authors: Fukuda K, Miyamae F, Tomita K, Yamaashi T, Ogawa Y, Yatsumoto K, Egawa M, Yamasaki A Abstract OBJECTIVE: In elderly patients, age-related, disease-related, and drug-related factors are associated with chronic kidney disease (CKD). Little is known about which factors are the best predictors for CKD in elderly patients. MATERIALS AND METHODS: The study was based on 784 patients a...
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
This study is a retrospective study based on medical records. Differences in the reactive hyperemia index (RHI) among the groups and factors affecting the RHI in each group was analyzed. The vascular endothelial function was assessed by measuring the RHI using peripheral arterial tonometry. Patients The study subjects were 114 patients with non-functional thyroid tumors (healthy n=14), T2DM (T2DM n=64), and RA (RA n=36). Results The RHI was 2.29 in the control, 1.85 in the T2DM, and 1.83 in the RA group, with values lower in the T2DM and RA groups than in the control group (p=0.033) but not markedly different between the t...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
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